Research Technician

About us

The UK Dementia Research Institute (UK DRI) is a globally leading multidisciplinary research institute of over 900 staff investigating the spectrum of neurodegenerative disorders causing dementia, driving a step change in our understanding of neurodegeneration, and accelerating the discovery, development and delivery of interventions that will help diagnose, treat, and ultimately prevent dementia.

The Bourdenx Lab at the UK DRI, led by Dr Mathieu Bourdenx, focuses on how age-related loss of cellular fitness in the brain drives neurodegeneration. Using cutting-edge spatial biology and single-cell approaches, the lab maps vulnerability and resilience in ageing brains. By combining molecular cell biology with computational tools - including AI-driven hypothesis generation - we aim to uncover novel mechanisms and therapeutic targets for Alzheimer’s disease and related dementias.

About the role

We are seeking a Research Technician to provide technical support by assisting lab members with a range of experimental procedures, data analysis, and general laboratory organisation. The role involves not only applying existing laboratory methods but also contributing to their optimisation and expansion. You will work under the direct supervision of the Group Leader, but you will also be expected to work independently and contribute to the design and execution of experiments on a day-to-day basis.

There may also be opportunities to support other members of the group in administering and monitoring anaesthesia in mice and in performing surgical procedures.

The post is available immediately and is funded by the Medical Research Council until 31 December 2026 in the first instance.

About you

You will hold a BSc (or equivalent) in a relevant discipline such as Neuroscience, Physiology, Biology, Medicine, or a related field. You will have hands-on experience with histological techniques, including perfusions, cryosectioning, and tissue staining (immunohistochemistry and immunofluorescence), as well as experience with in situ hybridisation and RNA biology. Experience with scientific programming (e.g., Python or R) and with imaging and image analysis using tools such as confocal microscopy, ImageJ, or Imaris is essential as is knowledge of neuroscience-related themes.