Understanding the role of microglia in Alzheimer’s using a novel humanised model of disease
Microglia, the brain’s resident immune cells, are implicated in Alzheimer’s and other neurodegenerative diseases, but the exact mechanisms behind this are not yet understood due to the complexities involved in studying them in human brain samples. A team led by Prof Bart De Strooper (UK DRI at UCL and VIB-KU Leuven) and Prof Renzo Mancuso (VIB-UAntwerp) has transplanted human microglia into mouse brains to better observe how the microglia respond to the disease environment. Their findings, published in Nature Neuroscience, will help scientists understand the complex mechanisms involved in Alzheimer's disease.
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