Abstract
Eur J Nucl Med Mol Imaging. 2025 Apr 25. doi: 10.1007/s00259-025-07257-4. Online ahead of print.
ABSTRACT
BACKGROUND: Inter-individual variability in tau topography challenges the propagation hypothesis of tau aggregates.
METHODS: To address this gap, we propose the Manifold Component Analysis (MCA), for identifying pseudo-continuous profiles informed by the spatial continuity of stage regions.
RESULTS: Longitudinal and cross-sectional MCA in large aging cohort identified individual profiles (N = 753) expressing tau load in the entorhinal, limbic and neocortical regions. Using these profiles, we found neuropsychological and blood-based milestones of early and late disease stages. Finally, we also found evidence of rapid tau load increases and cognitive decline centered at the early-to-mid neocortical stages of Alzheimer's disease.
CONCLUSIONS: Stage system based on tau load and spreading profiles across cortical areas provide a compelling framework for inferring pathophysiological prognosis in Alzheimer's disease.
PMID:40274672 | DOI:10.1007/s00259-025-07257-4
UK DRI Authors
