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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Alzheimer's & dementia (Amsterdam, Netherlands)
Published

Cerebrospinal fluid YKL-40 relates to white matter hyperintensity progression in females but not males over a 6-year period

Authors
Amalia J Peterson, Yunyi Sun, Derek B Archer, Hailey A Adegboye, Elizabeth E Moore, Isabella Deberghes, Kimberly R Pechman, Niranjana Shashikumar, W Hudson Robb, Abigail W Workmeister, T Bryan Jackson, Dandan Liu, Logan Dumitrescu, L Taylor Davis, Bennett A Landman, Kaj Blennow, Henrik Zetterberg, Timothy J Hohman, Angela L Jefferson
Cerebrospinal fluid YKL-40 relates to white matter hyperintensity progression in females but not males over a 6-year period
Cell reports
Published

A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons

Authors
Benedikt V Hölbling, Yashica Gupta, Paolo M Marchi, Magda L Atilano, Michael Flower, Enric Ureña, Rajkumar A Goulden, Hannah K Dobbs, Eszter Katona, Alla Mikheenko, Ashling Giblin, Ali Raza Awan, Chloe L Fisher-Ward, Niamh O'Brien, Deniz Vaizoglu, Liam Kempthorne, Katherine M Wilson, Lauren M Gittings, Mireia Carcolé, Marc-David Ruepp, Sarah Mizielinska, Linda Partridge, Pietro Fratta, Sarah J Tabrizi, Bhuvaneish T Selvaraj, Siddharthan Chandran, Emma Armstrong, Paul Whiting, Adrian M Isaacs
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
EBioMedicine
Published

Blood-brain barrier injury and neuroinflammation in pre-eclampsia and eclampsia

Authors
Valentina Bucher, Owen T Herrock, Sonja Schell, Jacqui Visser, Henrik Imberg, Jonathan Burke, Henrik Zetterberg, Kaj Blennow, Susan P Walker, Stephen Tong, Joakim Ek, Catherine Cluver, Lina Bergman
Blood-brain barrier injury and neuroinflammation in pre-eclampsia and eclampsia
BMC nephrology
Published

Plasma concentrations of neurofilament light, p-Tau231 and glial fibrillary acidic protein are elevated in patients with chronic kidney disease and correlate with measured glomerular filtration rate

Authors
Torunn Axelsson, Henrik Zetterberg, Kaj Blennow, Burak Arslan, Nicholas J Ashton, Markus Axelsson, Maria K Svensson, Aso Saeed, Gregor Guron
Plasma concentrations of neurofilament light, p-Tau231 and glial fibrillary acidic protein are elevated in patients with chronic kidney disease and correlate with measured glomerular filtration rate
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimer's disease

Authors
Bruna Bellaver, Guilherme Povala, Pamela C L Ferreira, Guilherme Bauer-Negrini, Firoza Z Lussier, Douglas T Leffa, João Pedro Ferrari-Souza, Matheus S Rodrigues, Livia Amaral, Markley S Oliveira, Carolina Soares, Andreia Rocha, Pampa Saha, Nesrine Rahmouni, Arthur Macedo, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jesse Klostranec, Maxime Montembeault, Andréa L Benedet, Nicholas J Ashton, Rebecca Langhough Koscik, Tobey J Betthauser, Brad T Christian, Rachael Wilson, Gallen Triana-Baltzer, Paolo Vitali, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Thomas K Karikari, Dana Tudorascu, Eduardo R Zimmer, Sterling Johnson, Pedro Rosa-Neto, Tharick A Pascoal
Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimer's disease
JAMA network open
Published

Cerebral Amyloid Angiopathy and Downstream Alzheimer Disease Plasma Biomarkers

Authors
Sung Hoon Kang, Eun Hye Lee, Young Ju Kim, Hyemin Jang, Daeun Shin, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Jihwan Yun, Hee Jin Kim, Duk L Na, Jun Pyo Kim, Sang Won Seo
Cerebral Amyloid Angiopathy and Downstream Alzheimer Disease Plasma Biomarkers
Molecular neurodegeneration
Published

Cerebrospinal fluid proteome profiling across the Alzheimer's disease continuum: a step towards solving the equation for 'X'

Authors
Sophia Weiner, Mathias Sauer, Laia Montoliu-Gaya, Andrea L Benedet, Nicholas J Ashton, Fernando Gonzalez-Ortiz, Joel Simrén, Nesrine Rahmouni, Cecile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Ville Leinonen, Tuomas Rauramaa, Mikko Hiltunen, Pedro Rosa-Neto, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Cerebrospinal fluid proteome profiling across the Alzheimer's disease continuum: a step towards solving the equation for 'X'
medRxiv : the preprint server for health sciences
Published

Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness

Authors
Devendra Meena, Jian Huang, Marjan Zare, Natalie R Hasbani, Boua Palwendé Romuald, Rima Mustafa, Sander W van der Laan, Huichun Xu, James G Terry, Joshua C Bis, Deepti Jain, Nicholette D Palmer, Nancy Heard-Costa, Yuan-I Min, Xiuqing Guo, Jie Yao, Kent D Taylor, Jingyi Tan, Juan Peralta, Alexandre C Pereira, Alyna Khan, Ananyo Choudhury, Anne B Newman, Anny H Xiang, Aroon Hingorani, Barry I Freedman, Christopher J O'Donnell, Claudia Giambartolomei, David M Herrington, David R Jacobs, Derek Klarin, Fei Fei Wang, Gerardo Heiss, HarshaVardhan Doddapaneni, Howard N Hodis, Jai Broome, James G Wilson, Jean-Tristan Brandenburg, John Blangero, Jose E Krieger, Josh D Smith, Karine A Viaud-Martinez, Kathleen A Ryan, Leslie A Lange, May E Montasser, Michael C Mahaney, Michal Mokry, Myriam Fornage, Patricia Munroe, Richard A Gibbs, Russell P Tracy, Ryan W Kim, Scott M Damrauer, Stephen S Rich, Willa A Hsueh, Yii-Der Ida Chen, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, The Million Veteran Program (MVP), TOPMed Atherosclerosis Working Group, Alanna C Morrison, Braxton D Mitchell, John Jeffrey Carr, Bruce M Psaty, Donald W Bowden, Ramachandran S Vasan, Adolfo Correa, Wendy S Post, Mark O Goodarzi, Leslie J Raffel, Joanne E Curran, Michele Ramsay, Jerome I Rotter, Paul Elliott, Nora Franceschini, Paul S de Vries, Ioanna Tzoulaki, Abbas Dehghan
Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness
Brain : a journal of neurology
Published

Altered T-cell reactivity in the early stages of Alzheimer's disease

Authors
Chiara Rickenbach, Anna Mallone, Lars Häusle, Larissa Frei, Sarina Seiter, Colin Sparano, Tunahan Kirabali, Kaj Blennow, Henrik Zetterberg, Maria Teresa Ferretti, Luka Kulic, Christoph Hock, Roger M Nitsch, Valerie Treyer, Anton Gietl, Christoph Gericke
Altered T-cell reactivity in the early stages of Alzheimer's disease
Cell reports
Published

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease

Authors
Elena Eubanks, Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin Sacks, Mahsa Darestani Farahani, Jinying Wang, Jordan Elliott, Nora Jaber, Fulya Akçimen, Sara Bandres-Ciga, Fadel Helweh, Jun Liu, Sanjana Archakam, Robert Kimelman, Bineet Sharma, Philip Socha, Ananya Guntur, Yiming Huang, Nagendran Ramalingam, Elyse Guadagno, Tim Bartels, Ulf Dettmer, M Maral Mouradian, Amir Houshang Bahrami, Wei Dai, Jean Baum, Zheng Shi, John Hardy, Eleanna Kara
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease