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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Scientific reports
Published

Association between herpes simplex virus infection and Alzheimer's disease biomarkers: analysis within the MAPT trial

Authors
Morgane Linard, Isabelle Garrigue, Bruno Vellas, Nicola Coley, Henrik Zetterberg, Kaj Blennow, Nicholas James Ashton, Pierre Payoux, Anne-Sophie Salabert, Jean-François Dartigues, Joachim Mazere, Sandrine Andrieu, Catherine Helmer
Association between herpes simplex virus infection and Alzheimer's disease biomarkers: analysis within the MAPT trial
Annals of neurology
Published

Clinical Relevance of 'Cap' and 'Track' Development after Recent Small Subcortical Infarct

Authors
Yajun Cheng, Carmen Arteaga-Reyes, Una Clancy, Daniela Jaime Garcia, Maria Del C Valdés Hernández, Michael J Thrippleton, Michael S Stringer, Gordon W Blair, Stewart Wiseman, Francesca M Chappell, Junfang Zhang, Xiaodi Liu, Angela C C Jochems, Susana Muñoz Maniega, Eleni Sakka, Mark E Bastin, Rosalind Brown, Caroline M J Loos, Stephen D J Makin, Ming Liu, Bo Wu, Fergus N Doubal, Joanna M Wardlaw, MSS‐2, MSS‐3 and the INVESTIGATE‐SVDs Study Group
Clinical Relevance of 'Cap' and 'Track' Development after Recent Small Subcortical Infarct
Science advances
Published

SMARCA4 regulates the NK-mediated killing of senescent cells

Authors
Virinder Reen, Mariantonietta D'Ambrosio, Pia Pernille Søgaard, Katie Tyson, Bryony J Leeke, Isabelle Clément, Isabel C A Dye, Joaquim Pombo, Adam Kuba, Yemin Lan, Joanna Burr, Ida C Bomann, Maria Kalyva, Jodie Birch, Sanjay Khadayate, George Young, Diane Provencher, Anne-Marie Mes-Masson, Santiago Vernia, Nicholas McGranahan, Hugh J M Brady, Francis Rodier, Raffaella Nativio, Michelle Percharde, Iain A McNeish, Jesús Gil
SMARCA4 regulates the NK-mediated killing of senescent cells
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Clinical utility of plasma p-tau217 in identifying abnormal brain amyloid burden in an Asian cohort with high prevalence of concomitant cerebrovascular disease

Authors
Joyce R Chong, Saima Hilal, Boon Yeow Tan, Narayanaswamy Venketasubramanian, Michael Schöll, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashton, Christopher P Chen, Mitchell K P Lai
Clinical utility of plasma p-tau217 in identifying abnormal brain amyloid burden in an Asian cohort with high prevalence of concomitant cerebrovascular disease
Nature genetics
Published

Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes

Authors
Alexander Haglund, Verena Zuber, Maya Abouzeid, Yifei Yang, Jeong Hun Ko, Liv Wiemann, Maria Otero-Jimenez, Louwai Muhammed, Rahel Feleke, Alexi Nott, James D Mills, Liisi Laaniste, Djordje O Gveric, Daniel Clode, Ann C Babtie, Susanna Pagni, Ravishankara Bellampalli, Alyma Somani, Karina McDade, Jasper J Anink, Lucia Mesarosova, Nurun Fancy, Nanet Willumsen, Amy Smith, Johanna Jackson, Javier Alegre-Abarrategui, Eleonora Aronica, Paul M Matthews, Maria Thom, Sanjay M Sisodiya, Prashant K Srivastava, Dheeraj Malhotra, Julien Bryois, Leonardo Bottolo, Michael R Johnson
Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Menopausal hormone therapy is associated with worse levels of Alzheimer's disease biomarkers in APOE ε4-carrying women: An observational study

Authors
Ainara Jauregi-Zinkunegi, Carey E Gleason, Barbara Bendlin, Ozioma Okonkwo, Bruce P Hermann, Kaj Blennow, Henrik Zetterberg, Eef Hogervorst, Sterling C Johnson, Rebecca Langhough, Kimberly D Mueller, Davide Bruno
Menopausal hormone therapy is associated with worse levels of Alzheimer's disease biomarkers in APOE ε4-carrying women: An observational study
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma p-tau<sub>217</sub> and neurofilament/p-tau<sub>217</sub> ratio in differentiating Alzheimer's disease from syndromes associated with frontotemporal lobar degeneration

Authors
Alberto Benussi, Hanna Huber, Kübra Tan, Valentina Cantoni, Jasmine Rivolta, Maria Sofia Cotelli, Andrea L Benedet, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Barbara Borroni
Plasma p-tau<sub>217</sub> and neurofilament/p-tau<sub>217</sub> ratio in differentiating Alzheimer's disease from syndromes associated with frontotemporal lobar degeneration
Nature communications
Published

Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo

Authors
Liam Kempthorne, Deniz Vaizoglu, Alexander J Cammack, Mireia Carcolé, Martha J Roberts, Alla Mikheenko, Alessia Fisher, Pacharaporn Suklai, Bhavana Muralidharan, François Kroll, Thomas G Moens, Lidia Yshii, Stijn Verschoren, Benedikt V Hölbling, Francisco C Moreira, Eszter Katona, Rachel Coneys, Paula de Oliveira, Yong-Jie Zhang, Karen Jansen, Lillian M Daughrity, Alexander McGown, Tennore M Ramesh, Ludo Van Den Bosch, Gabriele Lignani, Ahad A Rahim, Alyssa N Coyne, Leonard Petrucelli, Jason Rihel, Adrian M Isaacs
Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo
Communications medicine
Published

Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans

Authors
Bryan J Neth, Kevin Huynh, Corey Giles, Tingting Wang, Natalie A Mellett, Thy Duong, Colette Blach, Leyla Schimmel, Thomas C Register, Kaj Blennow, Henrik Zetterberg, Richa Batra, Annalise Schweickart, Amanda Hazel Dilmore, Cameron Martino, Matthias Arnold, Jan Krumsiek, Xianlin Han, Pieter C Dorrestein, Rob Knight, Peter J Meikle, Suzanne Craft, Rima Kaddurah-Daouk
Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans