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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Disclosure of plasma p-tau217 measure improves diagnostic confidence in patients with Alzheimer's disease versus syndromes associated with frontotemporal lobar degeneration

Authors
Valentina Cantoni, Maria Sofia Cotelli, Matteo Rota, Antonella Alberici, Ilenia Libri, Hanna Huber, Kübra Tan, Roberta Ghidoni, Sonia Bellini, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashton, Barbara Borroni
Disclosure of plasma p-tau217 measure improves diagnostic confidence in patients with Alzheimer's disease versus syndromes associated with frontotemporal lobar degeneration
Neurology
Published

Associations Between Changes in Levels of Phosphorylated Tau and Severity of Cognitive Impairment in Early Alzheimer Disease

Authors
Fernando Gonzalez-Ortiz, Bjørn-Eivind Kirsebom, Yara Yakoub, Julia K Gundersen, Lene Pålhaugen, Knut Waterloo, Per Selnes, Jonas Alexander Jarholm, Berglind Gísladóttir, Arvid Rongve, Ragnhild Eide Skogseth, Geir Bråthen, Dag Aarsland, Michael Turton, Peter Harrison, Henrik Zetterberg, Sylvia Villeneuve, Tormod Fladby, Kaj Blennow
Associations Between Changes in Levels of Phosphorylated Tau and Severity of Cognitive Impairment in Early Alzheimer Disease
Nature neuroscience
Published

Activity-driven myelin sheath growth is mediated by mGluR5

Authors
Philipp N Braaker, Xuelong Mi, Daniel Soong, Jenea M Bin, Katy Marshall-Phelps, Stephen Bradley, Silvia Benito-Kwiecinski, Julia Meng, Donia Arafa, Claire Richmond, Marcus Keatinge, Guoqiang Yu, Rafael G Almeida, David A Lyons
Activity-driven myelin sheath growth is mediated by mGluR5
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Misfolded α-synuclein co-occurrence with Alzheimer's disease proteinopathy

Authors
Erin M Jonaitis, Karen MacLeod, Jennifer Lamoureux, Beckie Jeffers, Rachel L Studer, John Middleton, Rachael E Wilson, Nathaniel A Chin, Ozioma C Okonkwo, Barbara B Bendlin, Sanjay Asthana, Cynthia M Carlsson, Catherine L Gallagher, Bruce Hermann, Sean McEvoy, Gwendlyn Kollmorgen, Henrik Zetterberg, Luis Concha-Marambio, Sterling C Johnson, Russ M Lebovitz, Rebecca E Langhough
Misfolded α-synuclein co-occurrence with Alzheimer's disease proteinopathy
Lancet (London, England)
Published

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial

Authors
Gilbert Bensimon, P Nigel Leigh, Timothy Tree, Andrea Malaspina, Christine Am Payan, Hang-Phuong Pham, Pieter Klaassen, Pamela J Shaw, Ahmad Al Khleifat, Maria D M Amador, Shahram Attarian, Simon M Bell, Stéphane Beltran, Emilien Bernard, William Camu, Philippe Corcia, Jean-Christophe Corvol, Philippe Couratier, Véronique Danel, Rabab Debs, Claude Desnuelle, Aikaterini Dimitriou, John Ealing, Florence Esselin, Marie-Céline Fleury, George H Gorrie, Aude-Marie Grapperon, Adèle Hesters, Raul Juntas-Morales, Ivan Kolev, Géraldine Lautrette, Nadine Le Forestier, Christopher J McDermott, Nicolas Pageot, François Salachas, Nikhil Sharma, Marie-Hélène Soriani, Jemeen Sreedharan, Juliette Svahn, Nick Verber, Annie Verschueren, Ozlem Yildiz, Carey M Suehs, Safaa Saker-Delye, Claudie Muller, Christophe Masseguin, Hana Hajduchova, Janine Kirby, Cecilia Garlanda, Massimo Locati, Henrik Zetterberg, Bernard Asselain, Ammar Al-Chalabi, MIROCALS Study Group
Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial
Alzheimer's & dementia (Amsterdam, Netherlands)
Published

Cerebrospinal fluid YKL-40 relates to white matter hyperintensity progression in females but not males over a 6-year period

Authors
Amalia J Peterson, Yunyi Sun, Derek B Archer, Hailey A Adegboye, Elizabeth E Moore, Isabella Deberghes, Kimberly R Pechman, Niranjana Shashikumar, W Hudson Robb, Abigail W Workmeister, T Bryan Jackson, Dandan Liu, Logan Dumitrescu, L Taylor Davis, Bennett A Landman, Kaj Blennow, Henrik Zetterberg, Timothy J Hohman, Angela L Jefferson
Cerebrospinal fluid YKL-40 relates to white matter hyperintensity progression in females but not males over a 6-year period
Cell reports
Published

A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons

Authors
Benedikt V Hölbling, Yashica Gupta, Paolo M Marchi, Magda L Atilano, Michael Flower, Enric Ureña, Rajkumar A Goulden, Hannah K Dobbs, Eszter Katona, Alla Mikheenko, Ashling Giblin, Ali Raza Awan, Chloe L Fisher-Ward, Niamh O'Brien, Deniz Vaizoglu, Liam Kempthorne, Katherine M Wilson, Lauren M Gittings, Mireia Carcolé, Marc-David Ruepp, Sarah Mizielinska, Linda Partridge, Pietro Fratta, Sarah J Tabrizi, Bhuvaneish T Selvaraj, Siddharthan Chandran, Emma Armstrong, Paul Whiting, Adrian M Isaacs
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
EBioMedicine
Published

Blood-brain barrier injury and neuroinflammation in pre-eclampsia and eclampsia

Authors
Valentina Bucher, Owen T Herrock, Sonja Schell, Jacqui Visser, Henrik Imberg, Jonathan Burke, Henrik Zetterberg, Kaj Blennow, Susan P Walker, Stephen Tong, Joakim Ek, Catherine Cluver, Lina Bergman
Blood-brain barrier injury and neuroinflammation in pre-eclampsia and eclampsia
BMC nephrology
Published

Plasma concentrations of neurofilament light, p-Tau231 and glial fibrillary acidic protein are elevated in patients with chronic kidney disease and correlate with measured glomerular filtration rate

Authors
Torunn Axelsson, Henrik Zetterberg, Kaj Blennow, Burak Arslan, Nicholas J Ashton, Markus Axelsson, Maria K Svensson, Aso Saeed, Gregor Guron
Plasma concentrations of neurofilament light, p-Tau231 and glial fibrillary acidic protein are elevated in patients with chronic kidney disease and correlate with measured glomerular filtration rate
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimer's disease

Authors
Bruna Bellaver, Guilherme Povala, Pamela C L Ferreira, Guilherme Bauer-Negrini, Firoza Z Lussier, Douglas T Leffa, João Pedro Ferrari-Souza, Matheus S Rodrigues, Livia Amaral, Markley S Oliveira, Carolina Soares, Andreia Rocha, Pampa Saha, Nesrine Rahmouni, Arthur Macedo, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jesse Klostranec, Maxime Montembeault, Andréa L Benedet, Nicholas J Ashton, Rebecca Langhough Koscik, Tobey J Betthauser, Brad T Christian, Rachael Wilson, Gallen Triana-Baltzer, Paolo Vitali, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Thomas K Karikari, Dana Tudorascu, Eduardo R Zimmer, Sterling Johnson, Pedro Rosa-Neto, Tharick A Pascoal
Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimer's disease
JAMA network open
Published

Cerebral Amyloid Angiopathy and Downstream Alzheimer Disease Plasma Biomarkers

Authors
Sung Hoon Kang, Eun Hye Lee, Young Ju Kim, Hyemin Jang, Daeun Shin, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Jihwan Yun, Hee Jin Kim, Duk L Na, Jun Pyo Kim, Sang Won Seo
Cerebral Amyloid Angiopathy and Downstream Alzheimer Disease Plasma Biomarkers