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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

The PREVENT-AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond

Authors
Sylvia Villeneuve, Judes Poirier, John C S Breitner, Jennifer Tremblay-Mercier, Jordana Remz, Jean-Michel Raoult, Yara Yakoub, Jonathan Gallego-Rudolf, Ting Qiu, Alfonso Fajardo Valdez, Bery Mohammediyan, Mohammadali Javanray, Amelie Metz, Safa Sanami, Valentin Ourry, Alfie Wearn, Alexandre Pastor-Bernier, Manon Edde, Julie Gonneaud, Cherie Strikwerda-Brown, Christine L Tardif, Claudine J Gauthier, Maxime Descoteaux, Mahsa Dadar, Étienne Vachon-Presseau, Andrée-Ann Baril, Simon Ducharme, Maxime Montembeault, Maiya R Geddes, Jean-Paul Soucy, Natasha Rajah, Robert Laforce, Christian Bocti, Christos Davatzikos, Lune Bellec, Pedro Rosa-Neto, Sylvain Baillet, Alan C Evans, D Louis Collins, M Mallar Chakravarty, Kaj Blennow, Henrik Zetterberg, R Nathan Spreng, Alexa Pichet Binette, PREVENT‐AD Research Group
The PREVENT-AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond
Neurology
Published

Continuous Positive Airway Pressure and Progression of Enlarged Perivascular Spaces in Adults With Obstructive Sleep Apnea

Authors
Rosa Sommer, Elizabeth A Hill, Joel Ramirez, Roberto Duarte Coello, Lucia Ballerini, Erin Gibson, Stephanie Berberian, Maria Del C Valdés Hernández, Andrew Centen, Francesca M Chappell, Nasim Montazeri, Michael S Stringer, Michael Thrippleton, Daniela Jaime Garcia, Stewart Wiseman, Marc Narayansingh, Anu Tandon, Mark I Boulos, Brian James Murray, Fergus Doubal, Renata L Riha, Maged Goubran, Bradley J Macintosh, Joanna M Wardlaw, Sandra E Black, Andrew S P Lim
Continuous Positive Airway Pressure and Progression of Enlarged Perivascular Spaces in Adults With Obstructive Sleep Apnea
Lancet (London, England)
Published

New landscape of the diagnosis of Alzheimer's disease

Authors
Giovanni B Frisoni, Oskar Hansson, Emma Nichols, Valentina Garibotto, Suzanne E Schindler, Wiesje M van der Flier, Frank Jessen, Nicolas Villain, Eider M Arenaza-Urquijo, Lucia Crivelli, Juan Fortea, Lea T Grinberg, Zahinoor Ismail, Satoshi Minoshima, Rik Ossenkoppele, Henrik Zetterberg, Ronald C Petersen, Bruno Dubois
New landscape of the diagnosis of Alzheimer's disease
Lancet (London, England)
Published

Treatment for Alzheimer's disease

Authors
Nick C Fox, Christopher Belder, Clive Ballard, Helen C Kales, Catherine Mummery, Paulo Caramelli, Olga Ciccarelli, Kristian S Frederiksen, Teresa Gomez-Isla, Zahinoor Ismail, Claire Paquet, Ronald C Petersen, Robert Perneczky, Louise Robinson, Ozge Sayin, Giovanni B Frisoni
Treatment for Alzheimer's disease
Lancet (London, England)
Published

Alzheimer's disease outlook: controversies and future directions

Authors
Giovanni B Frisoni, Emil Aho, Carol Brayne, Olga Ciccarelli, Bruno Dubois, Nick C Fox, Kristian S Frederiksen, Cem Gabay, Valentina Garibotto, Thomas Hofmarcher, Clifford R Jack, Miia Kivipelto, Ronald C Petersen, Federica Ribaldi, Christopher C Rowe, Sebastian Walsh, Henrik Zetterberg, Oskar Hansson
Alzheimer's disease outlook: controversies and future directions
Nature
Published

Collective homeostasis of condensation-prone proteins via their mRNAs

Authors
Rupert Faraway, Neve Costello Heaven, Holly Digby, Klara Kuret Hodnik, Jure Rebselj, Oscar G Wilkins, Anob M Chakrabarti, Ira A Iosub, Neža Vadnjal, Rhys Dore, Lea Knez, Stefan L Ameres, Clemens Plaschka, Jernej Ule
Collective homeostasis of condensation-prone proteins via their mRNAs
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology

Authors
Eric M McDade, Nicolas R Barthélemy, Guoqiao Wang, Yan Li, Yuchen Cao, Brian Gordon, Tammie L S Benzinger, David Clifford, Alison M Goate, Alan E Renton, Jason Hassenstab, Jorge J Llibre-Guerra, Richard J Perrin, Chengjie Xiong, Carlos Cruchaga, Catherine J Mummery, Sarah B Berman, James Lah, Erik D Roberson, Christopher Van Dyck, Serge Gauthier, Colin L Masters, Mario Masellis, Tobias Bittner, Roy Yaari, Jasmeer Chhatwal, Patricio Chrem, William Brooks, Kazushi Suzuki, Johannes J Levin, Mathias Jucker, John Ringman, David Wallon, Takeshi Ikeuchi, Jae-Hong Lee, Jee Hoon Roh, Peter Schofield, Nick C Fox, Natalie S Ryan, Jonathan Vöglein, Celeste Karch, Laura Ibáñez, Gregory S Day, Raquel Sánchez-Valle, Alisha Daniels, John C Morris, Charlene Supnet-Bell, Allan I Levey, Randall J Bateman, DIAN‐TU Study Team and DIAN Obs Team
The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published

Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP-43-Positive Assemblies in Motor Neuron Disease

Authors
Dezerae Cox, Melanie Burke, Sara Milani, Matthew A White, Fergal M Waldron, Dorothea Böken, Evgeniia Lobanova, Jemeen Sreedharan, Jenna M Gregory, David Klenerman
Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP-43-Positive Assemblies in Motor Neuron Disease
Nature metabolism
Published

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases

Authors
Femke M Feringa, Sascha J Koppes-den Hertog, Lian Y Wang, Rico J E Derks, Iris Kruijff, Lena Erlebach, Jorin Heijneman, Ricardo Miramontes, Nadine Pömpner, Niek Blomberg, Damien Olivier-Jimenez, Lill Eva Johansen, Alexander J Cammack, Ashling Giblin, Christina E Toomey, Indigo V L Rose, Hebao Yuan, Michael E Ward, Adrian M Isaacs, Martin Kampmann, Deborah Kronenberg-Versteeg, Tammaryn Lashley, Leslie M Thompson, Alessandro Ori, Yassene Mohammed, Martin Giera, Rik van der Kant
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
Disease models & mechanisms
Published

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation

Authors
Roza H A Masalmeh, John C Dawson, Virginia Alvarez Garcia, Morwenna T Muir, Roderick N Carter, Giles Hardingham, Cameron Davies, Rosina Graham, Alex von Kriegsheim, Jair Marques, Chinmayi Pednekar, Steven M Pollard, Neil O Carragher, Valerie G Brunton, Margaret C Frame
FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation
Molecular oncology
Published

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Authors
Adrien M Vaquié, Davod R Shah, Eliane E S Brechbühl, Michael McNicholas, Zhaoyang Xu, John H Stockley, Laura Morcom, Diana Gold Diaz, Gemma C Girdler, Rachel V Seear, Gabriel Balmus, Rajiv R Ratan, Harry Bulstrode, James A Nathan, Manav Pathania, Kevin M Brindle, David H Rowitch
Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
The Lancet. Neurology
Published

Association between the Edinburgh CT and genetic diagnostic criteria for cerebral amyloid angiopathy-associated lobar intracerebral haemorrhage and recurrent intracerebral haemorrhage: an individual patient data meta-analysis

Authors
Mark A Rodrigues, David Seiffge, Neshika Samarasekera, Tom J Moullaali, Joanna M Wardlaw, Stefanie Schreiber, Tyler P Behymer, Vivek Khandwala, Robert J Stanton, Vaibhav Vagal, Daniel Woo, Marialuisa Zedde, Rosario Pascarella, Andreas Charidimou, Andrew Warren, Steven M Greenberg, Sebastian Eppinger, Thomas Gattringer, Barbara Casolla, Charlotte Cordonnier, David J Werring, Rustam Al-Shahi Salman, Edinburgh CAA criteria prognosis collaborators
Association between the Edinburgh CT and genetic diagnostic criteria for cerebral amyloid angiopathy-associated lobar intracerebral haemorrhage and recurrent intracerebral haemorrhage: an individual patient data meta-analysis