Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
Ticks and tick-borne diseases
Published
Plasma levels of the neuron damage markers brain-derived tau and glial fibrillary acidic protein in Lyme neuroborreliosis: A longitudinal study
Authors
Mathilde Ørbæk, Fernando Gonzalez-Ortiz, Rosa M M Gynthersen, Åse Bengaard Andersen, Kubra Tan, Ulf Andreasson, Kaj Blennow, Helene Mens, Henrik Zetterberg, Anne-Mette Lebech
Plasma levels of the neuron damage markers brain-derived tau and glial fibrillary acidic protein in Lyme neuroborreliosis: A longitudinal study
The Lancet. Neurology
Published
Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial
Authors
Randall J Bateman, Yan Li, Eric M McDade, Jorge J Llibre-Guerra, David B Clifford, Alireza Atri, Susan L Mills, Anna M Santacruz, Guoqiao Wang, Charlene Supnet, Tammie L S Benzinger, Brian A Gordon, Laura Ibanez, Gregory Klein, Monika Baudler, Rachelle S Doody, Paul Delmar, Geoffrey A Kerchner, Tobias Bittner, Jakub Wojtowicz, Azad Bonni, Paulo Fontoura, Carsten Hofmann, Luka Kulic, Jason Hassenstab, Andrew J Aschenbrenner, Richard J Perrin, Carlos Cruchaga, Alan E Renton, Chengjie Xiong, Alison A Goate, John C Morris, David M Holtzman, B Joy Snider, Catherine Mummery, William S Brooks, David Wallon, Sarah B Berman, Erik Roberson, Colin L Masters, Douglas R Galasko, Suman Jayadev, Rachel Sanchez-Valle, Jeremie Pariente, Justin Kinsella, Christopher H van Dyck, Serge Gauthier, Ging-Yuek Robin Hsiung, Mario Masellis, Bruno Dubois, Lawrence S Honig, Clifford R Jack, Alisha Daniels, David Aguillón, Ricardo Allegri, Jasmeer Chhatwal, Gregory Day, Nick C Fox, Edward Huey, Takeshi Ikeuchi, Mathias Jucker, Jae-Hong Lee, Allan I Levey, Johannes Levin, Francisco Lopera, JeeHoon Roh, Pedro Rosa-Neto, Peter R Schofield, Dominantly Inherited Alzheimer's Disease–Trials Unit
Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial
The journal of prevention of Alzheimer's disease
Published
Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease
Authors
David M Cash, Katy E Morgan, Antoinette O'Connor, Thomas D Veale, Ian B Malone, Teresa Poole, Tammie Ls Benzinger, Brian A Gordon, Laura Ibanez, Yan Li, Jorge J Llibre-Guerra, Eric McDade, Guoqiao Wang, Jasmeer P Chhatwal, Gregory S Day, Edward Huey, Mathias Jucker, Johannes Levin, Yoshiki Niimi, James M Noble, Jee Hoon Roh, Racquel Sánchez-Valle, Peter R Schofield, Randall J Bateman, Chris Frost, Nick C Fox, Dominantly Inherited Alzheimer Network (DIAN)
Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease
Nature communications
Published
Computational memory capacity predicts aging and cognitive decline
Authors
Mite Mijalkov, Ludvig Storm, Blanca Zufiria-Gerbolés, Dániel Veréb, Zhilei Xu, Anna Canal-Garcia, Jiawei Sun, Yu-Wei Chang, Hang Zhao, Emiliano Gómez-Ruiz, Massimiliano Passaretti, Sara Garcia-Ptacek, Miia Kivipelto, Per Svenningsson, Henrik Zetterberg, Heidi Jacobs, Kathy Lüdge, Daniel Brunner, Bernhard Mehlig, Giovanni Volpe, Joana B Pereira
Computational memory capacity predicts aging and cognitive decline
The Clinical neuropsychologist
Published
Associations between the logical memory test story recall metrics and plasma biomarkers for Alzheimer's disease in individuals free of dementia
Authors
Ainara Jauregi-Zinkunegi, Rachael E Wilson, Rebecca E Langhough, Nicholas J Ashton, Kaj Blennow, Sterling C Johnson, Henrik Zetterberg, Davide Bruno, Kimberly D Mueller
Associations between the logical memory test story recall metrics and plasma biomarkers for Alzheimer's disease in individuals free of dementia
Brain, behavior, and immunity
Published
The schizophrenia-associated gene CSMD1 encodes a complement classical pathway inhibitor predominantly expressed by astrocytes and at synapses in mice and humans
Authors
Robert A J Byrne, Jacqui Nimmo, Megan Torvell, Sarah M Carpanini, Nikoleta Daskoulidou, Timothy R Hughes, Lucy V Noble, Aurora Veteleanu, Lewis M Watkins, Wioleta M Zelek, Michael C O'Donovan, B Paul Morgan
The schizophrenia-associated gene CSMD1 encodes a complement classical pathway inhibitor predominantly expressed by astrocytes and at synapses in mice and humans
The lancet. Psychiatry
Published
The trajectory of sedative adverse events caused by antipsychotics: a meta-analysis of individual participant data from randomised, placebo-controlled, clinical trials in acute phase schizophrenia
Authors
Nobuyuki Nomura, Spyridon Siafis, Johannes Schneider-Thoma, Lasse Brandt, Jinyoung Park, Orestis Efthimiou, Josef Priller, John M Davis, Hiroyoshi Takeuchi, Stefan Leucht
The trajectory of sedative adverse events caused by antipsychotics: a meta-analysis of individual participant data from randomised, placebo-controlled, clinical trials in acute phase schizophrenia
Movement disorders : official journal of the Movement Disorder Society
Published
Long-Term Stability of Spatial Distribution and Peak Dynamics of Subthalamic Beta Power in Parkinson's Disease Patients
Authors
Jennifer K Behnke, Robert L Peach, Jeroen G V Habets, Johannes L Busch, Jonathan Kaplan, Jan Roediger, Varvara Mathiopoulou, Lucia K Feldmann, Moritz Gerster, Juliette Vivien, Gerd-Helge Schneider, Katharina Faust, Patricia Krause, Andrea A Kühn
Long-Term Stability of Spatial Distribution and Peak Dynamics of Subthalamic Beta Power in Parkinson's Disease Patients
medRxiv : the preprint server for health sciences
Published
The impact of cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline
Authors
A J Paulsen, I Driscoll, B M Breidenbach, M P Glittenberg, S R Lose, Y Ma, M A Sager, C M Carlsson, C L Gallagher, B P Hermann, K Blennow, H Zetterberg, S Asthana, S C Johnson, T J Betthauser, B T Christian, D B Cook, O C Okonkwo
The impact of cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline
Acta neuropathologica
Published
Biofluid-based staging of Alzheimer's disease
Authors
Juan Lantero-Rodriguez, Laia Montoliu-Gaya, Nicholas J Ashton, Ilaria Pola, Joseph Therriault, Nesrine Rahmouni, Wagner S Brum, Stijn Servaes, Jenna Stevenson, Guglielmo Di Molfetta, Burak Arslan, Jesse Klostranec, Paolo Vitali, Maxime Montembeault, Serge Gauthier, Cecile Tissot, Arthur C Macedo, Tharick A Pascoal, Andreas Jeromin, Johan Gobom, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea L Benedet
Biofluid-based staging of Alzheimer's disease
Nature communications
Published
Axonal RNA localization is essential for long-term memory
Authors
Bruna R de Queiroz, Hiba Laghrissi, Seetha Rajeev, Lauren Blot, Fabienne De Graeve, Marine Dehecq, Martina Hallegger, Ugur Dag, Marion Dunoyer de Segonzac, Mirana Ramialison, Chantal Cazevieille, Krystyna Keleman, Jernej Ule, Arnaud Hubstenberger, Florence Besse
Axonal RNA localization is essential for long-term memory