Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Immunology
Published

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID

Authors
Samuel B K Keat, Priyanka Khatri, Youssif M Ali, Chanuka H Arachchilage, Gregory Demopulos, Kirsten Baillie, Kelly L Miners, Kristin Ladell, Samantha A Jones, Helen E Davies, David A Price, Wioleta M Zelek, B Paul Morgan, Wilhelm J Schwaeble, Nicholas J Lynch
Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published

The Mitochondrial Guardian α-Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK-SARM1-ULK1 Axis

Authors
Shu-Qin Cao, Juan Ignacio Jiménez-Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E Smith, Junjie Huang, Jun-Ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F Fang
The Mitochondrial Guardian α-Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK-SARM1-ULK1 Axis
The journal of prevention of Alzheimer's disease
Published

Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease

Authors
Claude M Wischik, Richard Stefanacci, Peter Bentham, Serge Gauthier, Henrik Zetterberg, Gordon K Wilcock, Lutz Froelich, Alistair Burns, Emer MacSweeney, Clive Ballard, Jin-Tai Yu, Tay Siew Choon, Vahe Asvatourian, Natalia Muehlemann, Jan Priel, Karin Kook, Tenecia Sullivan, Diane Downie, Sonya Miller, Carol Pringle, John M D Storey, Tom Baddeley, Charles R Harrington, Lewis K Penny, Mohammad Arastoo, Roger Staff, Anca-Larisa Sandu, Helen Shiells, Serena Lo, Nafeesa Nazlee, Emily Evans, Claire Hull, Bjoern O Schelter
Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease
BMC research notes
Published

Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort

Authors
Sarah E Keuss, Kirsty Lu, Sarah-Naomi James, Jennifer M Nicholas, William Coath, Ashvini Keshavan, David M Cash, Carole H Sudre, Josephine Barnes, Heidi Murray-Smith, Andrew Wong, Rebecca Street, Marcus Richards, Jonathan M Schott
Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort
Computer methods and programs in biomedicine
Published

Shape matters: Predicting Huntington's disease using progression modelling

Authors
Mohsen Ghofrani-Jahromi, Susmita Saha, Adeel Razi, Pubu M Abeyasinghe, Govinda R Poudel, Jane S Paulsen, Sarah J Tabrizi, Nellie Georgiou-Karistianis
Shape matters: Predicting Huntington's disease using progression modelling
bioRxiv : the preprint server for biology
Published

TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons, crypTEs, in iPSC derived neurons and ALS/FTD patient tissues

Authors
Isobel Bolger, Regina Shaw, Oliver H Tam, Cláudio Gouveia Roque, Christopher A Jackson, Kathryn O'Neill, NYGC ALS Consortium, Colin Smith, Hemali Phatnani, Karthick Natarajan, Molly Gale Hammell
TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons, crypTEs, in iPSC derived neurons and ALS/FTD patient tissues
Nature reviews. Neurology
Published

The Nottingham consensus on dementia risk reduction policy: recommendations from a modified Delphi process

Authors
Harriet Demnitz-King, Sube Banerjee, Claudia Cooper, Charlotte Kenten, Rosemary Phillips, Sedigheh Zabihi, Yvonne Birks, Carol Brayne, Sallyann Browning, Camille Carroll, Georgina Charlesworth, Carol Ac Coupland, Tom Dening, Ruth Dobson, Isabelle F Foote, Sarah Foster, Chris Fox, Robert Howard, Jeremy D Isaacs, Uzma Jaffry, Ivan Koychev, Gill Livingston, David J Llewellyn, Richard Oakley, Magdalena Opazo Bretón, Martin Orrell, Alastair J Noyce, Tommy Pouncey, Greta Rait, Janice Ranson, Mohammed Rauf, Vanessa Raymont, Elizabeth L Sampson, Jonathan M Schott, Debs Smith, Xin You Tai, Alison Thomson, Sebastian Walsh, Dylan M Williams, Naaheed Mukadam, Charles R Marshall, National Institute of Health and Care Research Policy Research Unit in Dementia and Neurodegeneration at Queen Mary University of London (DeNPRU-QM)
The Nottingham consensus on dementia risk reduction policy: recommendations from a modified Delphi process
Alzheimer's research & therapy
Published

Double cutoff strategies for plasma pTau217 to predict Tau PET positivity across multiple assay platforms: Tau-enriched and Tau-scarce cohorts for cost-effective clinical use

Authors
Heekyoung Kang, Yuna Gu, Jungah Lee, Soyeon Yoon, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Theresa A Day, Michael W Weiner, Daeun Shin, Sohyun Yim, Seonghyeon Kim, Hee Kyung Park, Min Young Chun, Eun Hye Lee, Jun Pyo Kim, Hee Jin Kim, Duk L Na, Hyemin Jang, Sang Won Seo, ADNI and K-ROAD study group
Double cutoff strategies for plasma pTau217 to predict Tau PET positivity across multiple assay platforms: Tau-enriched and Tau-scarce cohorts for cost-effective clinical use
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Elecsys pTau217 plasma immunoassay detection of amyloid pathology in clinical cohorts

Authors
Derrek P Hibar, Alina Bauer, Christina Rabe, Niels Borlinghaus, Alexander Jethwa, Gwendlyn Kollmorgen, Annunziata Di Domenico, Henrik Zetterberg, Kaj Blennow, Colin L Masters, Reisa A Sperling, Tobias Bittner
Elecsys pTau217 plasma immunoassay detection of amyloid pathology in clinical cohorts