Current Vacancies
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Key details
- Location: University of Surrey
- Salary: £37,694 to £43,482 per annum
- Lab: Prof Dijk
The University of Surrey is a global community of ideas and people, dedicated to life-changing education and research.
We are ambitious and have a bold vision of what we want to achieve - shaping ourselves into one of the best universities in the world, which we are achieving through the talents and endeavour of every employee.
Our culture empowers people to achieve this aim and to collectively, and individually, make a real difference.
The role
Applications are invited for a Postdoctoral Research Fellow position (28 months in the first instance) based in the Surrey Sleep Research Centre led by Professor Derk-Jan Dijk in the Faculty of Health and Medical Sciences.
This post is funded by the UK Dementia Research Institute (UK DRI) Care Research & Technology Centre, which is a collaboration between the University of Surrey and Imperial College London. The UK DRI is principally funded by the Medical Research Council.
This is an exciting opportunity to become part of a comprehensive interdisciplinary research programme
This project focuses on the application of digital health technology to study the contribution of sleep and circadian disturbance to brain function, neuropsychiatric symptoms and behaviour in people living with dementia.
The successful candidate will work across a variety of tasks and research methods to evaluate or develop andimplement technology for longitudinal assessment in the home environment.
About you
We are looking for an enthusiastic technology-oriented researcher with a particular interest in applying their skills do dementia.
You will hold a PhD in a relevant area such as neuroscience, biomedical engineering, psychology and have excellent coding and data analysis skills.
You will be highly motivated, collaborative, interested in technology and interdisciplinary research and willing to contribute to all aspects of the research project, from methodology development, data acquisition to data analysis.
For more information and informal discussions, please contact Prof Dijk (d.j.dijk@surrey.ac.uk; 01483 689341).
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Key details
- Location UK DRI at UCL
- Salary: £43,981-£52,586
- Lab: Professor Karen Duff
About us
The UK Dementia Research Institute (UK DRI) is the biggest UK initiative supporting research to fill the major knowledge gap in our basic understanding of the diseases that cause dementia.
Based within the UK DRI at UCL, the Duff Lab focuses on understanding and finding treatments for Alzheimer's disease (AD) and frontotemporal dementia (FTD), which are both linked to harmful changes in a protein called tau. These changes, known as tauopathies, cause damage in the brain and lead to dementia.
About the role
The Duff lab (working with the lab of Professor Jernej Ule at Kings College London) seeks a highly motivated, experienced, and self-driven individual to work on an exciting project that aims to look at context-dependent regulation of gene expression in cell, mouse and human systems in response to tau tangle formation and cellular clearance pathways. The project aims to identify suitable gating elements to be used to control the expression of genetic therapies in human AD and FTD-tau.
The project will involve the identification and analysis of RNA mediated gene regulators that respond to the cellular environment exposed to tau pathogenesis and TRIM11 clearance, and to the construction of novel components to control AVV transgene expression and return the cellular environment to homeostasis. The project will combine the Duff lab’s skills in cellular and mouse modelling of AD and FTD, and the Ule lab’s skills in RNA biology.
The post is immediately available and funded by Wellcome until 31 August 2027 in the first instance.
About you
You will hold a PhD in biological science (or be close to obtaining) with experience in RNA biology. Experience in advanced computational approaches to transcriptomics/gene regulation analysis, in microscopy and image acquisition, and in molecular biology is essential, as is experience in protein imagining and of data quality control, data analyses using appropriate software tools and data interpretation. Experience in tau biology and disease pathogenesis and in protein clearance pathways is desirable.