NPJ Parkinson's disease
Published

A community-led initiative to de-risk and advance Parkinson's disease therapeutic targets

Authors

Alexandra Vaiana, Jonathan Behr, Ryan Birol, Cornelis Blauwendraat, Bradford Casey, Kushan Chowdhury, Martin Citron, Joshua Crapser, Victoria Dardov, Fiona Ducotterd, Sonya Dumanis, John Dunlop, Michelle Durborow, Brian Fiske, Jessica Golden, Jonas Hannestad, Wendy Hung, Jennifer Kemp, Robin Kleiman, Adam Knight, Andrew Koemeter-Cox, Bruce Leuchter, Bejamin A Logsdon, Rita Marreiros, Julie E Miller, Amanda Mitchell, Pooja Mukherjee, Grace Navarro, Matthew R Nelson, Karoly Nikolich, Tom Otis, Nicole Polinski, Shima Rastegar-Pouyani, Alastair D Reith, Ekemini Riley, Lee Rubin, Mina Ryten, Jessica Sadick, Tina Schwabe, Todd Sherer, Sarah Silvergleid, Andrew Singleton, Lara St Clair, Jan Stoehr, David J Stone, Julianna Sullivan, Nicole Tanenbaum, Elisa Tinelli, Kate Trimble, Yifei Wang, Stacie Weninger, Nicolás Wiggenhauser, Stephen Wood, Darryle Schoepp, Virginie Buggia-Prevot, Shalini Padmanabhan, Gaia Skibinski
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Abstract

NPJ Parkinsons Dis. 2025 Jun 20;11(1):179. doi: 10.1038/s41531-025-01039-3.

ABSTRACT

Identifying effective therapeutic targets for Parkinson's disease (PD) is challenging, with no current disease-modifying therapies available. To address this, The Michael J. Fox Foundation for Parkinson's Research launched the Targets to Therapies (T2T) initiative, uniting experts to prioritize and validate promising targets. T2T aims to develop validation strategies, create comprehensive target data profiles, and build tools to support drug development, ultimately accelerating the discovery of new therapies for PD patients.

PMID:40541945 | DOI:10.1038/s41531-025-01039-3

UK DRI Authors

Fiona Ducotterd, smiling female with dark brown hair

Prof Fiona Ducotterd

UK DRI Co-investigator

Chief Scientific Officer of the Alzheimer's Research UK UCL Drug Discovery Institute

Prof Fiona Ducotterd
Mina Ryten

Prof Mina Ryten

Centre Director

Leveraging brain transcriptomics to understand the pathophysiology of Lewy body diseases

Prof Mina Ryten