Abstract
Am J Clin Nutr. 2025 May 20:S0002-9165(25)00264-3. doi: 10.1016/j.ajcnut.2025.05.011. Online ahead of print.
ABSTRACT
BACKGROUND: Anti-inflammatory dietary patterns are associated with slower cognitive decline in older adults; however, little is known about effects of an anti-inflammatory dietary pattern in middle-age.
OBJECTIVES: To adapt an anti-inflammatory diet to a multicultural setting and assess its impact on cognitive decline and Alzheimer's Disease risk and related dementias in healthy middle-aged adults.
METHODS: We performed a phase II pilot randomized clinical trial in adults (40-65 years old; n=290) in Bronx, New York. Participants were assigned to follow either the Multicultural Healthy Diet (MHD) an anti-inflammatory diet, or usual diet (Comparison). Diet was evaluated using National Cancer Institute's Automated Self-Administered 24-hr food records. The primary cognitive outcome was assessed at 9 months following randomization using a global composite score derived from three ambulatory cognitive assessments of visuospatial memory (Grid Memory), processing speed (Symbol Search) and short-term associative memory binding (Color Shapes). Secondary outcomes included performance on individual tests and association of dietary components with cognitive performance.
RESULTS: At 9 month follow-up the MHD arm had a lower Dietary Inflammatory Index (DII) score based on self-reported diet, with an adjusted MHD minus Comparison difference of -0.64 (95% CI: -1.02, -0.27) and -0.94 (95% CI: -1.34, -0.54) for the DII and energy-adjusted DII scores respectively, indicating intervention participants had adhered to an anti-inflammatory dietary pattern. Group session and telephone contact completion averaged 93% and 72% respectively for the MHD arm. No statistically significant difference between arms was found in the primary outcome- cognitive global score change- from baseline: -0.06 (95% CI: -0.15, 0.04), p=0.259.
CONCLUSIONS: The MHD was feasible and acceptable in this multicultural US cohort. While the influence of MHD at 9 months was non-significant based on the composite cognitive score, additional research using other measures such as day-to-day variability in cognitive function and peak performance is warranted.
CLINICAL TRIAL REGISTRY NUMBER: NCT03240406, https://clinicaltrials.gov/study/NCT03240406?term=Diet%20%26%20Cognition&page=3&rank=30. The protocol can be accessed at this website.
PMID:40412481 | DOI:10.1016/j.ajcnut.2025.05.011
UK DRI Authors
