Research Assistant in Single Cell Genomics

_{What you would be doing}

We are developing new methods for profiling the binding of transcription factors to DNA.  We need these methods to work at single cell resolution which is requiring us to push the limits of existing microfluidics capabilities. You will be responsible for developing, testing and implementing novel protocols towards this goal.  The Neurogenomics Lab is exploiting these technologies to enable genome function to be understood in disease relevant cell types. This is being done with a view towards commercialisation so would suit a highly motivated tech minded scientist with an engineering approach to molecular biology.

Working in state-of-the-art laboratories on Imperial’s newest campus for innovation in the heart of the west London tech corridor, the research group of Dr Nathan Skene in the UK DRI at Imperial seeks to identify regulatory mechanisms which cause neurodegenerative disorders, along with the cell types in which they act, and determine whether inhibition or activation of the pathway is associated with increased disease risk. Dr Skene’s research focuses on answering simple questions about brain diseases, through the analysis of epigenomic and genetic datasets. A major question of our group is identifying which cell types carry the most genetic load for brain disorders, by linking GWAS data to epigenomic data obtained using single cell methods.  This research area is evolving rapidly.  You will be given opportunities to train in new methods, develop new competencies relevant to the specific aims set and address major questions of importance for Alzheimer’s disease and related neurodegenerative conditions.

_{What we are looking for}

• Development of novel methods for single cell genomics, using customisable microfluidic platforms
• Experience with general molecular biology and cellular genomics methods
• Work collaboratively as part of a multidisciplinary research team
• Demonstrate an aptitude for an organised, methodical approach to your work