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About the role

The Barnes Lab is recruiting a postdoctoral research associate to use multiplexed synaptic proteomics to investigate how synaptic molecular complexity impacts synaptic function in health and early-stages of Alzheimer’s disease.  This position is available full time for one year, with the option to extend for three years. You will be supported and encouraged to apply for internationally competitive independent fellowships within this role.

Today, over 1 million people in the UK are living with dementia and related neurodegenerative disorders, such as Alzheimer’s, Parkinson’s, and motor neuron disease (MND). The impact of these incurable and progressive conditions on individuals and their families is devastating. The cost to the economy and public services is large and growing as the UK population ages. However, due to major advances in our understanding of the biology of these diseases, the scientific field is at a tipping point, with the next decade promising to deliver transformative breakthroughs in therapies and a new era of predictive, preventative, and precision medicine for neurodegenerative conditions. The UK is well placed to play a leading role in this revolution due to its scientific strengths in the field, led by the UK Dementia Research Institute (UK DRI) working with our world-class, university-based centres. We are a globally leading multidisciplinary research institute of over 900 staff investigating the spectrum of neurodegenerative disorders causing dementia, driving a step change in our understanding of neurodegeneration, and accelerating the discovery, development and delivery of interventions that will help diagnose, treat, and ultimately prevent dementia.

What you would be doing

The role will involve collection of data using in vivo 2-Photon imaging, confocal imaging, expansion microscopy and cycle-immunofluorescence approaches. A good background in neuroscience, data analysis and coding are essential. You will be expected to publish work, deliver presentations and contribute to funding application, leading where appropriate.

What we are looking for

You will be highly motivated and excited by the science with a background in neuroscience and experience in neuronal imaging technologies, and looking to use this role as a springboard toward securing an internationally competitive fellowship. You will have a track record of delivering high impact publications on AD-related pathogenesis and/or a related research area.