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We are looking to appoint a Research Assistant in Neurodegeneration in Dr Mallach’s research group focussing on understanding glial interactions during dementia development in neurodegeneration. Funded by ARUK, you will lead a project characterising the interactions of different cell types in human postmortem brain tissue. You will also develop workflows to analyse the generated images.

_{What you would be doing}

You will use immunohistochemistry techniques and confocal microscopy to study the interaction of cells and proteins in human postmortem brain tissue. You will analyse the images using

_{What we are looking for}

You will be highly motivated with demonstrable experience in staining and microscopy

You will be responsible for the analysis of the acquired images

_{About the role}

We are seeking a skilled Project Manager to support the strategic coordination and reporting on the ARIA (Advanced Research and Invention Agency) Project, under the direction of Dr Nir Grossman.

_{What you would be doing}

The post-holder will be responsible for overall financial, contractual and operational project management of the ARIA project, including all its collaborative projects; thus ensuring the ARIA project is delivered on time, on budget and complies with all relevant research and information governance regulations. A key responsibility is the management of all the finances for the project and creating quarterly reports for budgetary spend, including forecast reports to the funder.

Working closely with the Project PI and the departmental administrative team, you will lead on the coordination and submission of timely reports to funders and stakeholders, ensuring all deadlines are met. As a strong organiser and administrator, you will have scope to plan and prioritise your workload to meet essential deadlines and proactively manage the responsibilities of the role.

_{What we are looking for}

The postholder will be responsible for the effective and efficient day-to-day management and organisation.  Key responsibilities will include, but not limited to:

• Being flexible and proactive in a fast-paced environment, with the ability to consider both short- and long-term process improvements and service provision.
• Navigating a complex financial award involving multiple funded partners.
• Possessing a thorough understanding of the College's financial and human resource management systems, relevant to grant and payroll administration.
• Ensuring robust financial control throughout the ARIA Project and all its sub- and collaborative projects, including managing budgets for research grants, contracts, and general non-staff expenditure.
• Supporting the implementation of new systems introduced by the College/Faculty, in conjunction with the Departmental Management Team, related to research services, HR, and Finance.
• Assisting the PI, in consultation with the Research Office, in maximising income from research grants and contracts, including advising on preparing the financial elements of grant applications and management of grants/contracts awarded. Including regularly reviewing expenditure and advising project leads of problems, recommending an appropriate course of action which may involve liaising with administrative and senior staff from the grant-giving body.
• Managing sub-projects within the ARIA Project under Dr Grossman's leadership, to ensure timely delivery, budget adherence, and compliance with all relevant clinical, research, and governance regulations

_{What you would be doing}

We are developing new methods for profiling the binding of transcription factors to DNA.  We need these methods to work at single cell resolution which is requiring us to push the limits of existing microfluidics capabilities. You will be responsible for developing, testing and implementing novel protocols towards this goal.  The Neurogenomics Lab is exploiting these technologies to enable genome function to be understood in disease relevant cell types. This is being done with a view towards commercialisation so would suit a highly motivated tech minded scientist with an engineering approach to molecular biology.

Working in state-of-the-art laboratories on Imperial’s newest campus for innovation in the heart of the west London tech corridor, the research group of Dr Nathan Skene in the UK DRI at Imperial seeks to identify regulatory mechanisms which cause neurodegenerative disorders, along with the cell types in which they act, and determine whether inhibition or activation of the pathway is associated with increased disease risk. Dr Skene’s research focuses on answering simple questions about brain diseases, through the analysis of epigenomic and genetic datasets. A major question of our group is identifying which cell types carry the most genetic load for brain disorders, by linking GWAS data to epigenomic data obtained using single cell methods.  This research area is evolving rapidly.  You will be given opportunities to train in new methods, develop new competencies relevant to the specific aims set and address major questions of importance for Alzheimer’s disease and related neurodegenerative conditions.

_{What we are looking for}

• Development of novel methods for single cell genomics, using customisable microfluidic platforms
• Experience with general molecular biology and cellular genomics methods
• Work collaboratively as part of a multidisciplinary research team
• Demonstrate an aptitude for an organised, methodical approach to your work