Associations of β-Amyloid and Vascular Burden With Rates of Neurodegeneration in Cognitively Normal Members of the 1946 British Birth Cohort.

Authors

Sarah E Keuss, William Coath, Jennifer M Nicholas, Teresa Poole, Josephine Barnes, David M Cash, Christopher A Lane, Thomas D Parker, Ashvini Keshavan, Sarah M Buchanan, Aaron Z Wagen, Mathew Storey, Matthew Harris, Ian B Malone, Carole H Sudre, Kirsty Lu, Sarah-Naomi James, Rebecca Street, David L Thomas, John C Dickson, Heidi Murray-Smith, Andrew Wong, Tamar Freiberger, Sebastian Crutch, Marcus Richards, Nick C Fox, Jonathan M Schott

Abstract

The goals of this work were to quantify the independent and interactive associations of β-amyloid (Aβ) and white matter hyperintensity volume (WMHV), a marker of presumed cerebrovascular disease (CVD), with rates of neurodegeneration and to examine the contributions of APOE ε4 and vascular risk measured at different stages of adulthood in cognitively normal members of the 1946 British Birth Cohort.

PMID:35410910 | DOI: