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BMC Neurol
Published

Updating the study protocol: Insight 46 - a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development - phases 2 and 3.

Authors

Heidi Murray-Smith, Suzie Barker, Frederik Barkhof, Josephine Barnes, Thomas M Brown, Gabriella Captur, Molly R E Cartlidge, David M Cash, William Coath, Daniel Davis, John C Dickson, James Groves, Alun D Hughes, Sarah-Naomi James, Ashvini Keshavan, Sarah E Keuss, Josh King-Robson, Kirsty Lu, Ian B Malone, Jennifer M Nicholas, Alicja Rapala, Catherine J Scott, Rebecca Street, Carole H Sudre, David L Thomas, Andrew Wong, Selina Wray, Henrik Zetterberg, Nishi Chaturvedi, Nick C Fox, Sebastian J Crutch, Marcus Richards, Jonathan M Schott

Abstract

Although age is the biggest known risk factor for dementia, there remains uncertainty about other factors over the life course that contribute to a person's risk for cognitive decline later in life. Furthermore, the pathological processes leading to dementia are not fully understood. The main goals of Insight 46-a multi-phase longitudinal observational study-are to collect detailed cognitive, neurological, physical, cardiovascular, and sensory data; to combine those data with genetic and life-course information collected from the MRC National Survey of Health and Development (NSHD; 1946 British birth cohort); and thereby contribute to a better understanding of healthy ageing and dementia.

PMID:38263061 | DOI:10.1186/s12883-023-03465-3

UK DRI Authors

Selina Wray profile

Prof Selina Wray

UK DRI Affiliate Member - UCL

Professor of Molecular Neuroscience, UCL

Prof Selina Wray

Prof Henrik Zetterberg

Group Leader

Pioneering the development of fluid biomarkers for dementia

Prof Henrik Zetterberg