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Prof Caleb Webber

Director of Data Science & Group Leader

Combining state-of-the-art stem cell models with bioinformatics techniques to boost our understanding of the biological mechanisms underlying Parkinson’s disease

Biography

Prof Caleb Webber is combining state-of-the-art stem cell models with bioinformatics techniques to boost our understanding of the biological mechanisms underlying Parkinson’s disease. He is also aiming to identify new risk genes and investigate how these impact on the function of neurons. The team are also using advanced computational methods to investigate how genetic risk factors can influence a varying symptoms presented by patients. They hope to pinpoint key biological pathways that could be targeted with new drugs to prevent or treat Parkinson’s disease– and potentially other diseases with overlapping molecular causes.

In 2022, Prof Webber took on the additional role of UK DRI Director of Data Science. In this role, he is responsible for developing and implementing an Institute-wide strategy to harness the power of data resources and tools in our mission to find new treatments and technologies for dementia.

News

Key publications

Stem cell reports
Published
A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells
Authors
Galbha Duggal, Xinyu Li, Philippa Pettingill, Tatjana Lalic, Shailesh Kumar Gupta, Christine Flodgaard Høgsbro, Viola Volpato, Caleb Webber, Rory Bowden, Despoina Charou, Kanisa Arunasalam, Marcello Maresca, Ryan Hicks, Satyan Chintawar, M Zameel Cader
A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells
Nature communications
Published
GWAS of extended prescription analgesic use identifies genetic loci in chronic pain
Authors
Charli E Harlow, Emeka Uzochukwu, Hazel A Fernando, Charles E Mordaunt, Jordan M Hughey, John D Eicher, Lara Robinson, Nicholas Bowker, Laurence Howe, Jimmy Liu, Adrian Cortes, Paul Wilson, Usha Gungabissoon, Victoria S Benson, Anthony Nash, Gareth Young, Laura Addis, Chun-Fang Xu, Caleb Webber, Jonathan Davitte, M Zameel Cader
GWAS of extended prescription analgesic use identifies genetic loci in chronic pain

Webber Lab

Explore the work of the Webber Lab, combining state-of-the-art stem cell models with bioinformatics techniques to boost our understanding of the biological mechanisms underlying Parkinson’s disease

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