Giles Hardingham

Prof Giles Hardingham

Centre Director & Directors' Counsel

Studying astrocytes to better understand their role in helping maintain a healthy brain

Biography

An expert in cell signalling, Prof Giles Hardingham is The City of Edinburgh Professor of Pharmacology at the University of Edinburgh. Giles obtained his PhD from the MRC Laboratory of Molecular Biology in 1998, subsequently trained as an MRC postdoctoral researcher, before moving to the University of Edinburgh in 2002 as a Royal Society University Research Fellow. He became Professor of Molecular Neurobiology and a MRC Senior Research Fellow in 2010, and was elected Fellow of The Academy of Medical Sciences and the Royal Society of Edinburgh in 2018. As Centre Director of the UK DRI at Edinburgh, he oversees an exciting programme of research and lead work investigating astrocytes in neurodegenerative diseases.

News

Key publications

Disease models & mechanisms
Published
FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation
Authors
Roza H A Masalmeh, John C Dawson, Virginia Alvarez Garcia, Morwenna T Muir, Roderick N Carter, Giles Hardingham, Cameron Davies, Rosina Graham, Alex von Kriegsheim, Jair Marques, Chinmayi Pednekar, Steven M Pollard, Neil O Carragher, Valerie G Brunton, Margaret C Frame
FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation
The Lancet. Neurology
Published
Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial
Authors
Suvankar Pal, Jeremy Chataway, Robert Swingler, Malcolm R Macleod, Neil O Carragher, Giles Hardingham, Bhuvaneish Thangaraj Selvaraj, Colin Smith, Charis Wong, Judith Newton, Dawn Lyle, Amy Stenson, Rachel S Dakin, Amarachi Ihenacho, Shuna Colville, Arpan R Mehta, Nigel Stallard, James R Carpenter, Richard A Parker, Catriona Keerie, Christopher J Weir, Bruce Virgo, Stevie Morris, Nicola Waters, Beverley Gray, Donald MacDonald, Euan MacDonald, Mahesh K B Parmar, Siddharthan Chandran, MND SMART Investigators
Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial
Lancet Neurol
Published
Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial.
Authors
Suvankar Pal, Jeremy Chataway, Robert Swingler, Malcolm R Macleod, Neil O Carragher, Giles Hardingham, Bhuvaneish Thangaraj Selvaraj, Colin Smith, Charis Wong, Judith Newton, Dawn Lyle, Amy Stenson, Rachel S Dakin, Amarachi Ihenacho, Shuna Colville, Arpan R Mehta, Nigel Stallard, James R Carpenter, Richard A Parker, Catriona Keerie, Christopher J Weir, Bruce Virgo, Stevie Morris, Nicola Waters, Beverley Gray, Donald MacDonald, Euan MacDonald, Mahesh K B Parmar, Siddharthan Chandran,
Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial.

Hardingham Lab

Explore the work of the Hardingham Lab, studying astrocytes to better understand their role in helping maintain a healthy brain.

 
 
Hardingham Lab
Mixed species co-culture