Biography
Professor Henry Houlden FRCP, FRCPath, FMedSci is Professor of Neurology at the UCL Queen Square Institute of Neurology and a globally recognised leader in neurogenetics. His research focuses on defining the genetic architecture and molecular mechanisms underlying Parkinson’s disease and atypical parkinsonism, including multiple system atrophy (MSA), across diverse global populations.
His work has led to the identification of numerous disease-causing genes and genetic risk factors for movement disorders, defining new biological pathways and informing diagnostic and translational strategies. He has led several international genome-wide association studies and large-scale sequencing initiatives, uncovering key susceptibility loci and advancing understanding of disease heterogeneity.
Professor Houlden played an instrumental role in the 100,000 Genomes Project, with Patrick Chinnery leading the neurology and neurodegeneration GeCIP, coordinating one of the world’s largest cohorts of neurological disease genomes. He now leads the development and implementation of long-read DNA and RNA sequencing technologies in both research and diagnostic settings, aiming to transform the management of inherited neurological disorders.
At the UK DRI, Professor Houlden continues to expand population-scale genomic studies of Parkinson’s disease and atypical parkinsonism across the UK, integrating gene discovery, GWAS, biomarker development and translational research to accelerate therapeutic progress.
In addition to his research leadership, Professor Houlden works closely with patient organisations and advocacy groups to strengthen the bridge between genomic discovery and lived experience. He collaborates with charities such as Spotlight YOPD and other Parkinson’s and atypical parkinsonism networks MSA Trust and Parkinson's UK to support patient engagement, awareness, and the responsible communication of emerging genetic findings.