Prof Sir John Hardy

Group Leader

Harnessing genetics to build a better understanding of dementia

Condition

Alzheimer's disease, Parkinson's disease

Topics

Genetics

Biography

Prof Sir John Hardy is a world-leading neurogeneticist in the field of neurodegenerative diseases, receiving numerous accolades that include the Breakthrough Prize in Life Sciences, the Brain Prize, election as a Fellow of the Royal Society and, in 2022, a knighthood for his contributions to science and health. In 1991, Hardy's team uncovered the first mutation directly implicated in Alzheimer's disease leading to the formulation of the highly influential 'amyloid-cascade' hypothesis. His extensive body of work in genetics will be built upon in this UK DRI programme, where the team will unravel pathogenic networks in neurodegenerative disease.

News

Key publications

bioRxiv : the preprint server for biology
Published

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease

Authors
Elena Eubanks, Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin Sacks, Mahsa Darestani Farahani, Jinying Wang, Jordan Elliott, Nora Jaber, Fulya Akçimen, Sara Bandres-Ciga, Fadel Helweh, Jun Liu, Sanjana Archakam, Robert Kimelman, Bineet Sharma, Philip Socha, Ananya Guntur, Tim Bartels, Ulf Dettmer, M Maral Mouradian, Amir Houshang Bahrami, Wei Dai, Jean Baum, Zheng Shi, John Hardy, Eleanna Kara
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease
The EMBO journal
Published

Author Correction: Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models

Authors
Javier Rueda-Carrasco, Dimitra Sokolova, Sang-Eun Lee, Thomas Childs, Natália Jurčáková, Gerard Crowley, Sebastiaan De Schepper, Judy Z Ge, Joanne I Lachica, Christina E Toomey, Oliver J Freeman, John Hardy, Samuel J Barnes, Tammaryn Lashley, Beth Stevens, Sunghoe Chang, Soyon Hong
Author Correction: Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models
Brain communications
Published

Investigation of the genetic aetiology of Lewy body diseases with and without dementia

Authors
Lesley Yue Wu, Raquel Real, Alejandro Martinez-Carrasco, Ruth Chia, Michael A Lawton, Maryam Shoai, Catherine Bresner, Cornelis Blauwendraat, Andrew B Singleton, Mina Ryten, International Lewy Body Dementia Genomics Consortium, Sonja W Scholz, Bryan J Traynor, Nigel M Williams, Michele T M Hu, Yoav Ben-Shlomo, Donald G Grosset, John Hardy, Huw R Morris
Investigation of the genetic aetiology of Lewy body diseases with and without dementia
Science advances
Published

The annotation of <em>GBA1</em> has been concealed by its protein-coding pseudogene <em>GBAP1</em>

Authors
Emil K Gustavsson, Siddharth Sethi, Yujing Gao, Jonathan W Brenton, Sonia García-Ruiz, David Zhang, Raquel Garza, Regina H Reynolds, James R Evans, Zhongbo Chen, Melissa Grant-Peters, Hannah Macpherson, Kylie Montgomery, Rhys Dore, Anna I Wernick, Charles Arber, Selina Wray, Sonia Gandhi, Julian Esselborn, Cornelis Blauwendraat, Christopher H Douse, Anita Adami, Diahann A M Atacho, Antonina Kouli, Annelies Quaegebeur, Roger A Barker, Elisabet Englund, Frances Platt, Johan Jakobsson, Nicholas W Wood, Henry Houlden, Harpreet Saini, Carla F Bento, John Hardy, Mina Ryten
The annotation of <em>GBA1</em> has been concealed by its protein-coding pseudogene <em>GBAP1</em>

Hardy Lab

Explore the work of the Hardy Lab, harnessing genetics to build a better understanding of dementia

 
Hardy Lab