Maura Malpetti profile

Dr Maura Malpetti

Emerging Leader

Using specialist brain scans and novel blood tests to measure inflammation and accelerate the development of new treatments

Condition

Alzheimer's disease, Frontotemporal dementia

Topics

Immune system, Synapse & Circuitry, Biomarkers & diagnostics, Treatments & Interventions

Techniques

Bioinformatics, Flow cytometry, Fluid biomarkers, Human brain imaging, Statistical modelling

Biography

Dr Maura Malpetti is a Race Against Dementia Alzheimer’s Research UK Fellow and a Senior Research Associate in the Department of Clinical Neurosciences at the University of Cambridge. She originally trained in Italy for her BSc and MSc, and obtained her PhD in Clinical Neurosciences at the University of Cambridge. She further trained as a visiting researcher at the University of California San Francisco, and the Ludwig Maximilian University of Munich. Her research focusses on in vivo biomarkers for inflammation, tau and synaptic loss to investigate the pathophysiology of primary tauopathies, frontotemporal dementia, and related disorders. To this end, her lab integrates PET imaging and clinical data with fluid markers and post-mortem pathology to identify and validate early diagnostic and prognostic markers that can inform the design of new disease-modifying treatment strategies

News

Key publications

Nature neuroscience
Published

Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex

Authors
Rik Ossenkoppele, Emma M Coomans, Liana G Apostolova, Suzanne L Baker, Henryk Barthel, Thomas G Beach, Tammy L S Benzinger, Tobey Betthauser, Gérard N Bischof, Michel Bottlaender, Pierick Bourgeat, Anouk den Braber, Matthias Brendel, Adam M Brickman, David M Cash, Maria C Carrillo, William Coath, Bradley T Christian, Brad C Dickerson, Vincent Dore, Alexander Drzezga, Azadeh Feizpour, Wiesje M van der Flier, Nicolai Franzmeier, Giovanni B Frisoni, Valentina Garibotto, Elsmarieke van de Giessen, Juan Domingo-Gispert, Johannes Gnoerich, Yuna Gu, Yihui Guan, Bernard J Hanseeuw, Theresa M Harrison, Clifford R Jack, Elena Jaeger, William J Jagust, Willemijn J Jansen, Renaud La Joie, Keith A Johnson, Sterling C Johnson, Ian A Kennedy, Jun Pyo Kim, Koen van Laere, Julien Lagarde, Patrick Lao, José A Luchsinger, Silke Kern, William C Kreisl, Vincent Malotaux, Maura Malpetti, Jennifer J Manly, Xiaoxie Mao, Niklas Mattsson-Carlgren, Mayo Clinic Study on Aging, Konstantin Messerschmidt, Carolina Minguillon, Elizabeth M Mormino, John T O'Brien, Sebastian Palmqvist, Debora E Peretti, Ron C Petersen, Yolande A L Pijnenburg, Michael J Pontecorvo, Judes Poirier, PREVENT-AD Research Group, Gil D Rabinovici, Nesrine Rahmouni, Shannon L Risacher, Pedro Rosa-Neto, Howard Rosen, Christopher C Rowe, James B Rowe, Michael Rullmann, Yasmine Salman, Marie Sarazin, Andrew J Saykin, Julie A Schneider, Michael Schöll, Jonathan M Schott, Sang Won Seo, Geidy E Serrano, Sergey Shcherbinin, Mahnaz Shekari, Ingmar Skoog, Ruben Smith, Reisa A Sperling, Laure Spruyt, Erik Stomrud, Olof Strandberg, Joseph Therriault, Fang Xie, Rik Vandenberghe, Victor L Villemagne, Sylvia Villeneuve, Pieter Jelle Visser, Hillary Vossler, Christina B Young, Colin Groot, Oskar Hansson
Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex
JAMA
Published

Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity

Authors
Alexis Moscoso, Fiona Heeman, Sheelakumari Raghavan, Alejandro Costoya-Sánchez, Martijn van Essen, Ismini Mainta, Valle Camacho, Omar Rodríguez-Fonseca, Jesús Silva-Rodríguez, Andrés Perissinotti, Yuna Gu, Jihwan Yun, Debora Peretti, Federica Ribaldi, Emma M Coomans, Wagner S Brum, Michel J Grothe, Pablo Aguiar, Gérard N Bischof, Alexander Drzezga, Sang Won Seo, Sylvia Villeneuve, Maura Malpetti, John T O'Brien, James B Rowe, Elsmarieke M van de Giessen, Rik Ossenkoppele, William J Jagust, Ruben Smith, Oskar Hansson, Giovanni B Frisoni, Valentina Garibotto, David N Soleimani-Meigooni, Maria Carrillo, Bradford C Dickerson, Renaud La Joie, Gil D Rabinovici, Liana G Apostolova, Pamela J LaMontagne, Michael J Pontecorvo, Keith A Johnson, Reisa A Sperling, Michael W Weiner, Ronald C Petersen, Clifford R Jack, Prashanthi Vemuri, Michael Schöll, PREVENT-AD Research Group, the Harvard Aging Brain Study, the LEADS Consortium, and the Alzheimer’s Disease Neuroimaging Initiative
Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity
Movement disorders : official journal of the Movement Disorder Society
Published

Brain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy

Authors
Carla Palleis, Andrea Quattrone, Amir Dehsarvi, Sebastian N Roemer-Cassiano, Alexander M Bernhardt, AL‐108‐231 Investigators, the PASSPORT Study Group, Hans-Jürgen Huppertz, Maura Malpetti, Adam L Boxer, Johannes Gnörich, Lukas Frontzkowski, Johannes Levin, Matthias Brendel, Günter U Höglinger, Nicolai Franzmeier
Brain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference

Authors
Bess Frost, James B Rowe, Rufus O Akinyemi, Jose F Abisambra, Nicholas J Ashton, Matthias Brendel, Luc Buée, David Butler, Maria C Carrillo, Peter Chung, Claire D Clelland, Sarah L DeVos, Kristophe Diaz, Rebecca M Edelmayer, Fanny M Elahi, Ratnavalli Ellajosyula, Colin Ewen, Igor Camargo Fontana, Marie-Christine Galas, Oskar Hansson, Günter Höglinger, Kanta Horie, Agustín Ibanez, Linde Jacobs, Mahmoud B Maina, Maura Malpetti, Eric McDade, Will McEwan, Laia Montoliu-Gaya, Catherine J Mummery, Miranda E Orr, Jonathan D Rohrer, Amy Rommel, Carlos Sastre, Tara L Spires-Jones, Boon Lead Tee, Tim J Viney, Jamie M Walker, Susanne Wegmann, Kristin Wildsmith, Ravi Yadav, Simin Mahinrad, Claire Sexton
Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference

Malpetti Lab

Explore the work of the Malpetti Lab, focused on investigating inflammation in people living with dementia, to accelerate the development of new treatments.

Malpetti Lab
A brain with PSP dementia imaged with PET-TSPO