Dr Reiss Pal

BSc Hons MSc (DIC) PhD (He/Him)

Postdoctoral Researcher

Condition

Motor neuron disease/ALS, Other conditions

Topics

Immune system, Molecular mechanisms

Techniques

Advanced microscopy & imaging, Stem cells / iPSCs, Drug screening, Flow cytometry, Fluid biomarkers

Biography

Reiss joined the lab of Prof Siddharthan Chandran & Dr Bhuvaneish Selvaraj in 2024. As a research lead, he is using human embryonic stem cells (ESCs) and inducible pluripotent stem cells (iPSCs) to generate specialised brain cells which are dysfunctional in MND (motor neurons & astrocytes). Using these stem cell technologies, Reiss is interrogating the mechanisms that underlie MND pathology and screen high value candidate drugs for MND-SMART. 


Prior to joining Reiss worked as a Postdoctoral Researcher at the University of Cambridge. At Cambridge, Reiss was a research lead for the AZA-PD Parkinson’s Disease clinical trial in the lab of Dr Caroline Williams-Gray & Prof Roger Barker.

Honours & awards

Reiss received his PhD in Neuroimmunology at the University of Edinburgh, his MSc & DIC in Immunology from Imperial College London and his BSc (Hons) in Biomedical Science from Keele University. 

Key publications

Lancet Neurol
Published

Azathioprine for the treatment of early Parkinson's disease (AZA-PD): a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial.

Authors
Julia C Greenland, Kerry Dresser, Emma Cutting, Rachel Donegan, Simon Bond, Sarah J Crisp, Kirsten M Scott, Zanna J Voysey, Jonathan Holbrook, Lakmini Kahanawita, Reiss Pal, Marta Camacho, Alexander R D Peattie, Lennart R B Spindler, Young T Hong, Tim D Fryer, Caroline H Williams-Gray
Azathioprine for the treatment of early Parkinson's disease (AZA-PD): a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial.
Neurobiol Dis
Published

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology.

Authors
Jennifer Stables, Reiss Pal, Barry M Bradford, Dylan Carter-Cusack, Isis Taylor, Clare Pridans, Nemat Khan, Trent M Woodruff, Katharine M Irvine, Kim M Summers, Neil A Mabbott, David A Hume
The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology.

Links