Join us

About the role:

The team of Prof. Jernej Ule is seeking a Laboratory Technician to join a team of researchers working on the roles of ribonucleoprotein complexes (RNP) and their defects in neurodegenerative disorders.

The post holder will focus on biochemistry and molecular biology techniques, in particular transcriptomic studies of RNA regulation and protein-RNA interactions, maintenance and characterisation of human cell lines, preparation of cell extracts, RNA extraction and general biochemistry such as western blots, thus contributing to relevant publications in collaboration with other team members.

The post is based at the Ule Regulatory RNA Networks lab at UKDRI Centre at King’s. The lab consists of 8 researchers including PhD students and postdoctoral fellows. For more information, please see the laboratory website.

This is a full time (35 hours per week), and you will be offered a fixed term contract until 30/09/2027

About you:

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

1. MSc in Biochemistry, Molecular Biology, Neurobiology, Cell Biology or a related discipline
2. Experience in molecular and cellular biology
3. Experience with transcriptomic studies of gene expression
4. Experience in experimental design and bench work
5. IT proficiency (Spreadsheet, Word Processing, Database, Email, Web based applications)
6. Excellent communication and organizational skills, with a meticulous and accurate approach to work.
7. Strong problem-solving abilities
8. Excellent inter-personal skills with an ability to work co-operatively in a multidisciplinary setting

Desirable criteria

1. Experience with bioinformatics
2. Experience in studies of protein-RNA complexes
3. Experience in immunostaining
4. Experience with differentiating iPS cells into neurons
5. Interest in and a commitment to supporting high quality research

About the role:

Dr Daniel Solomon is seeking a Research Assistant to support a research project investigating how mutations in the TDP-43 protein associated with amyotrophic lateral sclerosis and frontotemporal dementia alter nuclear pore transport and its interaction with the nuclear pore permeability barrier. This role will contribute to advancing mechanistic understanding of how disease-associated mutations disrupt nucleocytoplasmic transport, a key feature of neurodegeneration.

The postholder will work closely with the Principal Investigator and will undertake a combination of biochemical and cell-based experimental approaches. This will include recombinant protein expression and purification, in vitro assays, fluorescence microscopy (including FRAP), and cell-based transport assays. The Research Assistant will contribute to data acquisition, quantitative analysis, and optimisation of experimental workflows, ensuring high standards of reproducibility and scientific rigour.

The role offers the opportunity to work on a multidisciplinary project at the interface of cell biology, biophysics and neurodegeneration research. The postholder will also support the organisation and day-to-day running of the laboratory, maintain accurate experimental records, and contribute to the timely delivery of project objectives.

This is a fixed-term position focused on delivering key experimental outputs within a defined study, with scope to contribute to publications and future funding applications.

This is a full-time post (35 hours per week), and you will be offered a fixed-term contract until 30/11/26.

About you:

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

1. MSc/BSc/MSc in cell biology, biochemistry, biophysics, neuroscience or a related discipline.
2. Practical laboratory experience in molecular biology and/or protein biochemistry (e.g. protein expression and purification).
3. Experience working with mammalian cell culture and basic cell biology techniques.
4. Experience with fluorescence microscopy and image acquisition (e.g. confocal imaging).
5. Ability to perform quantitative data analysis and interpret experimental results.
6. Strong organisational skills and the ability to manage and prioritise experimental work across multiple assays.
7. Excellent attention to detail and commitment to reproducible, high-quality research.
8. Good communication skills and ability to work effectively as part of a research team.

Desirable criteria

1. Experience with protein biochemistry or working with recombinant proteins.
2. Experience with phase separation or biomolecular condensate assays.
3. Experience working with image-based data analysis tools.
4. Familiarity with cell-based assays in a research laboratory setting.
5. Experience working in a multidisciplinary research environment (e.g. combining cell biology, biochemistry or biophysics approaches).

About the role:

Dr Andrea Serio & Dr. Sarah Marzi are seeking a highly motivated and skilled Research Associate at the UK Dementia Research Institute (UK DRI) at King’s College London.

This opportunity would suit a bright, talented, highly motivated, and ambitious individual to who will play a key role working on a project focused on the development of a multiomic platform to investigate early molecular signatures of ALS pathology in human motor neurons using a novel system developed in the Serio lab.

The successful candidate will have a demonstrable track record and experience bioinformatics and data analysis, particularly -omics approaches in biology and a keen interest in neuroscience and neurodegeneration. Demonstrable experience dealing with iPSC-derived cultures and data in the context of neurobiology or neurodegeneration studies is desirable.

The successful candidate will have at least a PhD in a relevant field and postdoctoral experience in a research lab with projects, preferably focused on neurobiology or neurodegeneration.

The post holder will work with other team members across the Serio and Marzi lab to generate stem cell-based models of ALS using a novel cell culture platform developed in the Serio lab for the study of axons, and will lead on the multiomic analysis to compare different genotypes.

The post holder will specifically generate multiomic data, including next-generation sequencing and proteomic data from in vitro models of ALS, and analyse newly generated data and public datasets that may include RNA-seq, ATAC-seq, proteomics and single cell/nuclei datasets.

Successful candidates will be highly motivated with demonstrable experience in multiomics and bioinformatics, with an interest or basic understanding of stem cell modelling applied to neuroscience and neurodegeneration studies.

The post will be linked to a MNDA project and a UK DRI funded programme and will take place between the Basic & Clinical Neuroscience department and the Francis Crick Institute.

Some of the key skills involved include;

• To conduct high quality research under the supervision of Dr Serio and Dr Marzi, and in collaboration with other members of the Serio group.
• To present findings in regular group meetings to the PI and colleagues.
• Work in a collaborative manner, sharing knowledge and expertise within the team, department and with collaborators.

This is a full -time post (35 hours per week) and you will be offered a fixed term contract until 30/09/2028

About you:

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

1. PhD in Neurobiology or related subject with clear track record of bioinformatics, data analysis -omics analysis.
2. Postdoctoral experience in a neuroscience or neuroengineering project.
3. Knowledge of basic neuroscience, neurodegenerative diseases and ALS
4. Strong programming skills in R, python or other coding languages
5. Practical experience with a high-performance computing and Unix/Linux environments
6. Practical experience in a broad range of bioinformatics approaches, including the analyses of some or all the following assays: 

•       RNA-seq (NGS and longreads) 

•       Single cell genomics 

•       ChIP-seq/CUT&Tag/ATAC-seq 

•       Proteomics 

Desirable criteria

1. Ability to work with version control systems, i.e., Git and GitHub
2. Experience in iPSC-derived in vitro models
3. Knowledge of next-generation genomic approaches, specifically those pertaining to RNA and chromatin biology
4. Practical cell culture skills