Prof Bart De Strooper

Group Leader

Investigating the cellular reaction to amyloid beta and tau protein in Alzheimer's disease

Condition

Alzheimer's disease

Biography

Prof Bart De Strooper is a world-renowned Alzheimer's disease researcher, formerly based at the KU Leuven in Belgium, and was the founding Institute Director for the UK DRI (2017- 2023). 

He was Director at the Vlaams Instituut voor Biotechnologie and led a neuroscience department of over 250 researchers. He was elected to the Academy of Medical Sciences Fellowship in 2020, and has received several awards including the Potamkin prize, the Metlife Foundation Award for Medical Research, Alois Alzheimer’s prize, the highly prestigious Brain Prize 2018 and Commander in the Order of Leopold I. 

Prof De Strooper's research group at the UK DRI at UCL interrogates the fundamental mechanisms underlying Alzheimer’s and Parkinson’s disease.

News

Key publications

Cell reports
Published
APOE3 and APOE4 human astrocytes differentially modulate Alzheimer's disease pathology and microglial responses in chimeric mice
Authors
Joan Cruz-Sese, Marta Mirón-Alcala, María Alfonso-Triguero, Jon Olalde, Leire Ruiz, Nuria Galbis-Gramage, Lorea Cortes, Laura Escobar, Pranav Preman, An Snellinx, Takashi Saito, Takaomi C Saido, Laura Saiz-Aúz, Alberto Rábano-Gutiérrez, Ana M Aransay, Ibai Diez, Julia Tcw, Alison Goate, Bart De Strooper, Elena Alberdi, Amaia M Arranz
APOE3 and APOE4 human astrocytes differentially modulate Alzheimer's disease pathology and microglial responses in chimeric mice
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Recent Cochrane review has serious flaws: A perspective of clinicians and researchers from around the world
Authors
Heather M Snyder, Malavika P Tampi, Paul S Aisen, Ricardo Allegri, Liana G Apostolova, Alireza Atri, Sheena Aurora, Paulo Caramelli, Lucia Crivelli, Jeffrey Cummings, Bart de Strooper, Nick C Fox, Lea Tenenholz Grinberg, John Hardy, Bruce T Lamb, Allan Levey, Oscar Lopez, Catherine Mummery, Ricardo Nitrini, Sarah Pahlke, Ronald C Petersen, K Joanne Pike, Anton P Porsteinsson, Gil D Rabinovici, Michael Rafii, Rema Raman, Marwan N Sabbagh, Stephen P Salloway, Philip Scheltens, Jonathan M Schott, Dennis J Selkoe, Gustavo Sevlever, Reisa Sperling, Malu Gamez Tansey, Christopher van Dyck, Henrik Zetterberg, Maria C Carrillo
Recent Cochrane review has serious flaws: A perspective of clinicians and researchers from around the world
Nature medicine
Published
Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience
Authors
Ashley Lu, Wei-Ting Chen, Maria Dalby, Diego Sainz Garcia, Marisa Vanheusden, Luuk E de Vries, Veerle van Lieshout, Araks Martirosyan, Katleen Craessaerts, Sebastiaan Moonen, Magdalena Zielonka, Iordana Chrysidou, Anke Misbaer, Leen Wolfs, Benjamin Pavie, Dick Swaab, Dietmar Rudolf Thal, Inge Huitinga, Annemieke Rozemuller, Susan Karijn Rohde, Marc Hulsman, Henne Holstege, Rita Balice-Gordon, Niels Plath, Mark Fiers, Bart De Strooper
Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience

De Strooper Lab

Explore the work of the De Strooper Lab Investigating the cellular reaction to amyloid beta and tau protein in Alzheimer's disease

 
De Strooper Lab