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Dr Soyon Hong

Group Leader

Dissecting pathways by which microglia contribute to region-specific synapse dysfunction in neurodegeneration

Biography

Dr Soyon Hong received her PhD in Neuroscience in 2012 from Harvard University and completed her post-doctoral fellowship at Boston Children’s Hospital and Harvard Medical School in 2018. While in this latter role, she conducted a study that was among the first to propose microglia as critical players in synaptic pathology in disease. She now brings these expertise and knowledge to establish a new UK DRI lab group at UCL.

Statement on teaching and mentorship

"I have mentored and taught many students and technicians through lectures and laboratory settings (26 mentees in laboratory settings to date). I highly value the opportunities to mentor. It is one aspect of my career that I find truly rewarding. I believe that having a positive, stimulating environment where trainees are valued is key to having a productive and creative lab. Trainees who join my laboratory will be trained in cellular and molecular biology including neuroscience and neuroimmunology. Moreover, they will be mentored to be independent critical thinkers, a core of my teaching philosophy."

News

Key publications

Science (New York, N.Y.)
Published
C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain
Authors
Gerard Crowley, Minjung Kim, Nathanael O'Neill, Emir Turkes, Fateme Ghasemi, Luca Giudice, Sebastiaan De Schepper, Benjy J Y Tan, Benito Maffei, Laís S S Ferreira, Julie Rebejac, Javier Rueda-Carrasco, Margarita Toneva, John Christian Fajardo, Judy Z Ge, Zhengyue Grace Yang, Paula Korhonen, Phillip Muckett, Damaris Bennett, Camille Paoletti, Tammie T M Sow, David A Posner, Annerieke Sierksma, Dimitra Sokolova, Viktoras Konstantellos, Leen Ali, Kiavash Movahedi, Andrew F MacAskill, Victor L J Tybulewicz, Tarja Malm, Gabriele Lignani, Menna R Clatworthy, Soyon Hong
C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain
Nature
Published
Focal white matter lesions drive grey matter inflammation and synapse loss
Authors
Omar de Faria, Stavros Vagionitis, Andrea Lopez-Lopez, Michael Perry, Joseph Jo Yin Wong, Leslie Rodríguez-Kirby, Bastien Hervé, Balazs Viktor Varga, Eneritz Agirre, Sabrina Ghosh, Sebastian Timmler, Mert Yucel, Andrew T Setley, Kimberley Anne Evans, Tanja Mist Birgisdóttir, Sindri Gíslason, Yan Ting Ng, Courtney Kremler, Helene O B Gautier, Yasmine Kamen, Helena Pivonkova, Katrin Volbracht, Felix Hildebrand, Christian A Cepeda, Javier Rueda-Carrasco, Soyon Hong, George Malliaras, Sabine Dietmann, Gonçalo Castelo-Branco, Ragnhildur Thóra Káradóttir
Focal white matter lesions drive grey matter inflammation and synapse loss

Hong Lab

Explore the work of the Hong Lab, working to understand immune mechanisms of neural circuitry and function

Three-dimensional reconstruction of perivascular macrophages