Abstract
NPJ Parkinsons Dis. 2025 Apr 13;11(1):75. doi: 10.1038/s41531-025-00938-9.
ABSTRACT
The influence of Lewy body (LB) and tau co-pathologies is increasingly acknowledged as putatively affecting neurodegeneration and clinical phenotypes. Here, we injected rhesus macaques with LB fractions or/and tau seeds derived from patients brains into distinct brain areas connected to the mesencephalon. Compared to control macaques, we observed increased mesencephalic staining of pathological α-synuclein and tau, as well as nigrostriatal dopaminergic neuronal loss, with a cumulative effect of co-pathology.
PMID:40221462 | DOI:10.1038/s41531-025-00938-9