Unilateral lesion of the suprachiasmatic nucleus impairs estradiol feedback, follicular development, estrous cycle and ovulation.
Authors
Carlos-Camilo Silva, Diana Pamela Benítez, Angélica Flores, Georgina Daniela Cortés, Elizabeth Vieyra, Cinthia Rocío Juárez-Tapia, Jessica Romero-Reyes, Roberto Domínguez, Diana P Benitez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M Hall, Carlijn Peerboom, Natalie Wong, Katie M Stringer, Karina S Vitanova, Victoria C Smith, Dhaval Joshi, Takashi Saito, Takaomi C Saido, John Hardy, Jörg Hanrieder, Bart De Strooper, Dervis A Salih, Takshashila Tripathi, Frances A Edwards, Damian M Cummings, Karina S Vitanova, Katie M Stringer, Diana P Benitez, Jonathan Brenton, Damian M Cummings
The SCN regulates ovulation by stimulating the preovulatory surge of gonadotropins. This study revealed an additional role in the sensitization of the hypothalamus to estradiol that changes along the estrous cycle and the side of the nucleus.
