Skip to main content
Search
Main content

Prof Sir John Hardy

Group Leader

Harnessing genetics to build a better understanding of dementia

Biography

Prof Sir John Hardy is a world-leading neurogeneticist in the field of neurodegenerative diseases, receiving numerous accolades that include the Breakthrough Prize in Life Sciences, the Brain Prize, election as a Fellow of the Royal Society and, in 2022, a knighthood for his contributions to science and health. In 1991, Hardy's team uncovered the first mutation directly implicated in Alzheimer's disease leading to the formulation of the highly influential 'amyloid-cascade' hypothesis. His extensive body of work in genetics will be built upon in this UK DRI programme, where the team will unravel pathogenic networks in neurodegenerative disease.

News

Key publications

American journal of human genetics
Published
Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk
Authors
Olivier Quenez, Catherine Schramm, Kévin Cassinari, Aude Nicolas, Joan Groeneveld, Guillaume Huguet, Benjamin Grenier-Boley, Marc Hulsman, G Bragi Walters, Itziar de Rojas, Anne Rovelet-Lecrux, Sébastien Feuillette, Laetitia Miguel, Anne-Claire Richard, Stéphane Rousseau, Shahzad Ahmad, Najaf Amin, Philippe Amouyel, Olivia Belbin, Céline Bellenguez, Claudine Berr, Paola Bossù, Femke Bouwman, Jose Bras, Jordi Clarimon, Antonio Daniele, Jean-François Dartigues, Stéphanie Debette, Jean-François Deleuze, Nicola Denning, Oriol Dols-Icardo, Cornelia M van Duijn, Juan Fortea, Nick C Fox, Ruth Frikke-Schmidt, Daniela Galimberti, Roberta Ghidoni, Vilmantas Giedraitis, Johan J P Gille, Detelina Grozeva, Rita Guerreiro, Edna Grünblatt, John Hardy, Steffi G Riedel-Heller, Mikko Hiltunen, Clive Holmes, Jakub Hort, Holger Hummerich, M Arfan Ikram, M Kamran Ikram, Martin Ingelsson, Iris E Jansen, Amit Kawalia, Robert Kraaij, Patrick G Kehoe, Marc Lathrop, Morgane Lacour, Afina W Lemstra, Alberto Lleó, Lauren Luckcuck, Marcel M A M Mannens, Rachel Marshall, Carlo Masullo, Simon Mead, Patrizia Mecocci, Alexandre de Mendonça, Alun Meggy, Shima Mehrabian, Merel O Mol, Kevin Morgan, Alexandre Morin, Benedetta Nacmias, Penny J Norsworthy, Robert Olaso, Florence Pasquier, Pau Pastor, Fabrizio Piras, Julius Popp, Alfredo Ramirez, Rachel Raybould, Richard Redon, Marcel J T Reinders, Fernando Rivadeneira, Jeroen G J van Rooij, Natalie S Ryan, Salha Saad, Pascual Sanchez-Juan, Nikolaos Scarmeas, Philip Scheltens, Jonathan M Schott, Davide Seripa, Daoud Sie, Rebecca Sims, Erik A Sistermans, Sandro Sorbi, Kristel Sleegers, Resie van Spaendonk, John C van Swieten, Niccolo' Tesi, Betty M Tijms, Magda Tsolaki, André G Uitterlinden, Jort Vijverberg, Pieter Jelle Visser, Michael Wagner, Julie Williams, Aline Zarea, EADB Consortium, Emmanuelle Génin, Henne Holstege, Daniel F Gudbjartsson, David Wallon, Magalie Lecourtois, Maria Victoria Fernandez, Hreinn Stefansson, Sébastien Jacquemont, Jean-Charles Lambert, Sven J van der Lee, Camille Charbonnier, Gaël Nicolas
Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk
Nature genetics
Published
PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures
Authors
Audrey Coulon, Florian Rabiller, Mari Takalo, Avishek Roy, Alexandre Pelletier, Henna Martiskainen, Dolores Siedlecki-Wullich, Nina Lannette-Weimann, Naďa Majerníková, Arthur Grenon, Vance Gao, Anaël Erhardt, Anne Pernodet, Morgane Lemaire, Floriane Limoge, Pauline Walle, Tiago Mendes, Karine Guyot, Célia Lemeu, Lukas-Iohan Carvalho, Ana Raquel Melo de Farias, Marc Hulsman, Chloé Najdek, Alejandra Freire-Regatillo, Orthis Saha, Philippe Amouyel, Camille Charbonnier, Jean-François Deleuze, Orio Dols-Icardo, Heli Jeskanen, Roosa-Maria Willman, Teemu Kuulasmaa, Mitja Kurki, John Hardy, Sami Heikkinen, Henne Holstege, Petra Mäkinen, Gaël Nicolas, Simon Mead, Michael Wagner, Alfredo Ramirez, Tuomas Rauramaa, Aarno Palotie, Rebecca Sims, Hilkka Soininen, John van Swieten, Julie Williams, Céline Bellenguez, Carla Gelle, Erwan Lambert, Marcos R Costa, Julia Tcw, Enrico Glaab, Anne-Marie Ayral, Florie Demiautte, Benjamin Grenier-Boley, Manon Muntaner, Delphine Eberlé, Séverine Deforges, Joel T Haas, Devrim Kilinc, Christophe Mulle, Julien Chapuis, Mikko Hiltunen, Julie Dumont, Jean-Charles Lambert
PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures
Annals of neurology
Published
Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk
Authors
Andrés Peña-Tauber, Ricardo Hernández Arriaza, Dylan Reil, Manon Muntaner, Junyoung Park, Benjamin Grenier-Boley, Marc Hulsman, Philippe Amouyel, Céline Bellenguez, Camille Charbonnier, Jean-François Deleuze, Orio Dols-Icardo, John Hardy, Henne Holstege, Gaël Nicolas, Simon Mead, Michael Wagner, Alfredo Ramirez, Rebecca Sims, John van Swieten, Julie Willams, Jean-Charles Lambert, Chaitan Khosla, Yann Le Guen, Michael D Greicius
Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Recent Cochrane review has serious flaws: A perspective of clinicians and researchers from around the world
Authors
Heather M Snyder, Malavika P Tampi, Paul S Aisen, Ricardo Allegri, Liana G Apostolova, Alireza Atri, Sheena Aurora, Paulo Caramelli, Lucia Crivelli, Jeffrey Cummings, Bart de Strooper, Nick C Fox, Lea Tenenholz Grinberg, John Hardy, Bruce T Lamb, Allan Levey, Oscar Lopez, Catherine Mummery, Ricardo Nitrini, Sarah Pahlke, Ronald C Petersen, K Joanne Pike, Anton P Porsteinsson, Gil D Rabinovici, Michael Rafii, Rema Raman, Marwan N Sabbagh, Stephen P Salloway, Philip Scheltens, Jonathan M Schott, Dennis J Selkoe, Gustavo Sevlever, Reisa Sperling, Malu Gamez Tansey, Christopher van Dyck, Henrik Zetterberg, Maria C Carrillo
Recent Cochrane review has serious flaws: A perspective of clinicians and researchers from around the world

Hardy Lab

Explore the work of the Hardy Lab, harnessing genetics to build a better understanding of dementia