The Vascular Models Database aims to capture the different models of vascular contributions to cognitive impairment being used within the research community. The purpose of this database is to serve as a directory of who is using which models and for what purpose and should serve as a collaborative platform.
If you would like to add a new model or add further information to an existing model on the database, please fill out the form here or contact helen.brooks@ukdri.ac.uk.
Global knock-out of Atp11b model
Genetic background
Sprague Dawley
Type of model
Small vessel disease
Species
Rat
Strain common name
Atp11bKO
Severe hypertension and cerebral stroke model
Genetic background
Wistar-Kyoto
Type of model
Small vessel disease
Species
Rat
Strain common name
SHRSP
Hypoperfusion to the brain
Genetic background
C57BL/6J
Intervention
Stenosis
Type of model
Vascular cognitive impairment (i.e. chronic hypoperfusion)
Species
Mouse
Strain common name
-
Chronic pericyte deficiency
Genetic background
129S1/SvlmJ
Type of model
Small vessel disease
Species
Mouse
Strain common name
Pdgfrb F7
Brain pericyte lineage tracing
Genetic background
C57BL/6J
Type of model
Tool (i.e. cellular manipulation, labelling, tracking)
Species
Mouse
Strain common name
Atp13a5 tdT
Focal cerebral ischaemia model
Genetic background
C57BL/6J
Intervention
Occlusion
Type of model
Ischemic stroke
Species
Mouse
Strain common name
-
Overexpression of mutant human APP(swe) model
Genetic background
C57BL/6J
Type of model
Alzheimer's disease
Species
Mouse
Strain common name
APP23
Ischaemic stroke in cortex (CD-1) model
Genetic background
CD-1
Intervention
Occlusion
Type of model
Ischemic stroke
Species
Mouse
Strain common name
-
Ischaemic stroke in cortex (C57BL/6J) model
Genetic background
C57BL/6J
Intervention
Occlusion
Type of model
Ischemic stroke
Species
Mouse
Strain common name
-
Intracerebral haemorrhage in the striatum model
Genetic background
Sprague Dawley
Intervention
Haemorrhagic
Type of model
Haemorrhagic stroke
Species
Rat
Strain common name
-