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Animal models database

The Vascular Models Database aims to capture the different models of vascular contributions to cognitive impairment being used within the research community. The purpose of this database is to serve as a directory of who is using which models and for what purpose and should serve as a collaborative platform.
 
If you would like to add a new model or add further information to an existing model on the database, please fill out the form here or contact helen.brooks@ukdri.ac.uk.
 

Global knock-out of Atp11b model

Genetic background

Sprague Dawley

Type of model

Small vessel disease

Species

Rat

Strain common name

Atp11bKO
Global knock-out of Atp11b model

Hypoperfusion to the brain

Genetic background

C57BL/6J

Intervention

Stenosis

Type of model

Vascular cognitive impairment (i.e. chronic hypoperfusion)

Species

Mouse

Strain common name

-
Hypoperfusion to the brain

Chronic pericyte deficiency

Genetic background

129S1/SvlmJ

Type of model

Small vessel disease

Species

Mouse

Strain common name

Pdgfrb F7
Chronic pericyte deficiency

Brain pericyte lineage tracing

Genetic background

C57BL/6J

Type of model

Tool (i.e. cellular manipulation, labelling, tracking)

Species

Mouse

Strain common name

Atp13a5 tdT
Brain pericyte lineage tracing

Focal cerebral ischaemia model

Genetic background

C57BL/6J

Intervention

Occlusion

Type of model

Ischemic stroke

Species

Mouse

Strain common name

-
Focal cerebral ischaemia model