Dr Alexi Nott

Group Leader

Investigating how the epigenome regulates cell type specific gene expression in ageing-related brain disorders

Condition

Alzheimer's disease, Parkinson's disease

Biography

An expert in neuroepigenomics, Dr Alexi Nott joined the UK DRI at Imperial in Autumn 2020 from the University of California, San Diego. Dr Nott’s interest in epigenetics began during his MRC-funded PhD in the lab of Prof Antonella Riccio at LMCB, UCL. He moved to MIT in 2011 as a postdoctoral fellow to continue his studies investigating the role of epigenetics in postnatal development and autism-related behaviours, before being awarded an Alzheimer’s Association Research Fellowship program at the University of California, San Diego. During this time, Dr Nott generated cell-type specific enhancer-promoter connectivity maps of the human brain and identified that genetic risk variants for Alzheimer’s disease are largely located in active gene regulatory elements in microglia. As Group Leader at UK DRI at Imperial, Dr Nott is building on his research into gene regulation in ageing-related brain disorders.

News

Key publications

International journal of stroke : official journal of the International Stroke Society
Published
The Vascular Contribution to Dementia. World Stroke Organisation Scientific Statement
Authors
Geert Jan Biessels, Stephanie Debette, Fanny M Elahi, Fatemeh Geranmayeh, Gurpreet Hansra, Timothy M Hughes, Masafumi Ihara, Jeremy Isaacs, Hanna Jokinen, Alexi Nott, Sarah Pendlebury, Ruth Peters, Julie Schneider, Colin Smith, Eric Edward Smith, Prashanthi Vemuri, Joanna Wardlaw, Alastair Webb, Donna M Wilcock, Atticus H Hainsworth
The Vascular Contribution to Dementia. World Stroke Organisation Scientific Statement
Alzheimer's research & therapy
Published
Genetic drivers of progression in Alzheimer's disease are distinct from disease risk
Authors
Celeste E Cohen, Shane Fernandez, Umran Yaman, Ahmad R Ehyaei, Eleftheria Kodosaki, Aydan Askarova, Tenielle Porter, Eleanor O'Brien, Australian Imaging Biomarkers and Lifestyle Study, Alzheimer’s Disease Neuroimaging Initiative, Paul Maruff, Alexi Nott, John A Hardy, Simon M Laws, Dervis A Salih, Maryam Shoai
Genetic drivers of progression in Alzheimer's disease are distinct from disease risk
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Basic Science and Pathogenesis
Authors
Alexi Nott
Basic Science and Pathogenesis
Neuron
Published
The brain neurovascular epigenome and its association with dementia
Authors
Kevin Chris Ziegler, Aydan Askarova, Charbel Gergian, Reuben M Yaa, Janna D van Dalen, Janis Lisa Transfeld, Filippo Zoppi, Jia Du, Daniel Clode, Fatemeh Rahbar, Rebecca E Graham, Muralidharan Sargurupremraj, Stéphanie Debette, David D Gonda, Michael L Levy, Siddharthan Chandran, Sven Falk, Marisa Karow, Paul M Matthews, Nicole G Coufal, Alexi Nott
The brain neurovascular epigenome and its association with dementia

Nott Lab

Explore the work of the Nott Lab, investigating how the epigenome regulates cell type specific gene expression in ageing-related brain disorders

Nott Lab
Histone proteins wrapped around DNA illustration