Dr James Conway

PhD (He/Him)

Postdoctoral Researcher

Uncovering the pathways of α-synuclein spreading along the Gut-Immune-Brain Axis using novel disease models and patient tissue, and a mix of histological and proteomic methods.

Condition

Lewy body dementia, Other conditions, Parkinson's disease

Topics

Ageing, Immune system, Molecular mechanisms, Biomarkers & diagnostics, Synapse & Circuitry

Techniques

Advanced microscopy & imaging, Bioinformatics, Structural biology, Mouse behaviour

Biography

James is a Research Fellow in the Bartels lab at the UK DRI at UCL. He began his career at the University of Bristol, studying the effects of GDNF in Parkinson's disease models. He then completed a PhD in Prof. Edgar Kramer's group at the University of Plymouth studying the role of NEDD4 ubiquitin ligases in dopaminergic function and in novel Parkinson's disease models. Following a role at the Francis Crick Institute, James joined Tim Bartels' lab at the UK DRI at UCL, where he has created and characterised novel models of synucleinopathies, and published work on the gut-immune-brain axis in Parkinson's disease.

Research interest

Parkinson's disease, Dementia with Lewy bodies, Multiple System Atrophy, Biomarkers, Enteric Nervous System, Protein Biochemistry

Key publications

Nature
Published

Intestinal macrophages modulate synucleinopathy along the gut-brain axis

Authors
Sebastiaan De Schepper, Viktoras Konstantellos, James A Conway, Dimitra Sokolova, Ludovica Zaccagnini, Matthew V Cowley, Annerieke Sierksma, Maria Yudina, Marisa Edmonds, Daria Gavriouchkina, Bethany Geary, Amber Wallis, Meral Celikag, Zeynep Baykam, Mónica Vara-Pérez, Gerard Crowley, Fabian Tobias Hager, Mitchell Bijnen, David Posner, Kelvin Luk, Vuk Cerovic, Menna Clatworthy, Elizabeth J Videlock, Zane Jaunmuktane, Kiavash Movahedi, Melanie Greter, Benny Chain, Dario R Alessi, Soyon Hong, Tim Bartels
Intestinal macrophages modulate synucleinopathy along the gut-brain axis