Joanna Wardlaw

Prof Joanna Wardlaw

(CBE, MB ChB (Hons), MD, FRCR, FRCP, FMedSci, FRSE (she/her))

Group Leader and Clinical Director of the CVDR

Discovering how small vessel disease damages the brain and what we can do to prevent or treat it

Condition

Alzheimer's disease, Vascular dementia, Mild cognitive impairment

Topics

Ageing, Cell biology of neurons & glia, Lifestyle & environment, Molecular mechanisms, Vascular system, Biomarkers & diagnostics, Treatments & Interventions

Techniques

Advanced microscopy & imaging, Drug screening, Experimental medicine, Fluid biomarkers, Human brain imaging, Lipidomics, Mass spec-based proteomics, Metabolomics, Mouse behaviour, Mouse in vivo imaging, Single cell / nucleus transcriptomics, Software development, Statistical modelling, Viral-mediated expression

Biography

Prof Joanna Wardlaw, CBE, MB ChB (Hons), MD, FRCR, FRCP, FMedSci, FRSE, is Professor of Applied Neuroimaging at the University of Edinburgh, Foundation Chair of the UK DRI at Edinburgh, Director of the Row Fogo Centre for Research into Ageing and the Brain, and Consultant Neuroradiologist for NHS Lothian. Her work focuses on understanding the brain and its blood supply, and treatments to improve blood flow to the brain, including thrombolytic drugs that are now in routine use to treat stroke, and more recently treatments for small vessel disease and vascular dementia. Working with many colleagues, she has been instrumental in advancing understanding of the causes of cerebral small vessel disease and is now testing treatments in clinical trials. She has set up national research imaging facilities, co-ordinated international research networks, advanced stroke care worldwide and published over 1000 papers. A Fellow of the Royal Society of Edinburgh and the UK Academy of Medical Sciences, she has received awards from many UK and international brain and heart organisations, and was made a Commander of the Order of the British Empire (CBE) for services to Medicine and Neuroscience in 2016.

News

Key publications

Journal of the American Heart Association
Published

Choroid Plexus Volume in Rural Chinese Older Adults: Distribution and Association With Cardiovascular Risk Factors and Cerebral Small Vessel Disease

Authors
Chunyan Li, Huisi Zhang, Jiafeng Wang, Xiaodong Han, Cuicui Liu, Yuanjing Li, Tao Gong, Tingting Hou, Yongxiang Wang, Lin Cong, Grégoria Kalpouzos, Joanna Wardlaw, Lin Song, Yifeng Du, Chengxuan Qiu
Choroid Plexus Volume in Rural Chinese Older Adults: Distribution and Association With Cardiovascular Risk Factors and Cerebral Small Vessel Disease
JAMA network open
Published

Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds

Authors
Simon Fandler-Höfler, Sebastian Eppinger, Gareth Ambler, Philip Nash, Markus Kneihsl, Keon-Joo Lee, Jae-Sung Lim, Masayuki Shiozawa, Masatoshi Koga, Linxin Li, Caroline Lovelock, Hugues Chabriat, Michael Hennerici, Yuen Kwun Wong, Henry Ka Fung Mak, Luis Prats-Sanchez, Alejandro Martínez-Domeño, Shigeru Inamura, Kazuhisa Yoshifuji, Ethem Murat Arsava, Solveig Horstmann, Jan Purrucker, Bonnie Yin Ka Lam, Adrian Wong, Young Dae Kim, Tae-Jin Song, Robin Lemmens, Ender Uysal, Zeynep Tanriverdi, Natan M Bornstein, Einor Ben Assayag, Hen Hallevi, Jeremy Molad, Masashi Nishihara, Jun Tanaka, Shelagh B Coutts, Alexandros Polymeris, Benjamin Wagner, David J Seiffge, Philippe Lyrer, L Jaap Kappelle, Rustam Al-Shahi Salman, Maria Valdes Hernandez, Hans R Jäger, Gregory Y H Lip, Urs Fischer, Marwan El-Koussy, Jean-Louis Mas, Laurence Legrand, Christopher Karayiannis, Thanh Phan, Sarah Gunkel, Nicolas Christ, Jill Abrigo, Winnie Chu, Thomas Leung, Francesca Chappell, Stephen Makin, Derek Hayden, David J Williams, Werner H Mess, M Eline Kooi, Carmen Barbato, Simone Browning, Anil M Tuladhar, Noortje Maaijwee, Anne Cristine Guevarra, Anne-Marie Mendyk, Christine Delmaire, Sebastian Köhler, Robert van Oostenbrugge, Ying Zhou, Chao Xu, Saima Hilal, Caroline Robert, Christopher Chen, Min Lou, Julie Staals, Régis Bordet, Nagaendran Kandiah, Frank-Erik de Leeuw, Robert Simister, Daniel Bos, Peter J Kelly, Joanna Wardlaw, Yannie Soo, Felix Fluri, Velandai Srikanth, David Calvet, Simon Jung, Vincent I H Kwa, Stefan T Engelter, Nils Peters, Eric E Smith, Hideo Hara, Yusuke Yakushiji, Dilek Necioglu Orken, Vincent Thijs, Ji Hoe Heo, Vincent Mok, Roland Veltkamp, Hakan Ay, Toshio Imaizumi, Kui Kai Lau, Eric Jouvent, Peter M Rothwell, Kazunori Toyoda, Hee-Joon Bae, Joan Marti-Fabregas, Duncan Wilson, Jonathan Best, Franz Fazekas, Christian Enzinger, David J Werring, Thomas Gattringer, Microbleeds International Collaborative Network
Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds
Research square
Published

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease

Authors
Stephanie Debette, Ilana Caro, Daniel Western, Shinichi Namba, Na Sun, Shuji Kawaguchi, Yunye He, Masashi Fujita, Gennady Roshchupkin, Tim D'Aoust, Marie-Gabrielle Duperron, Murali Sargurupremraj, Ami Tsuchida, Masaru Koido, Marziehsadat Ahmadi, Chengran Yang, Jigyasha Timsina, Laura Ibanez, Koichi Matsuda, Yutaka Suzuki, Yoshiya Oda, Akinori Kanai, Pouria Jandaghi, Hans Markus Munter, Dan Auld, Iana Astafeva, Raquel Puerta, Jerome Rotter, Bruce Psaty, Joshua Bis, Will Longstreth, Thierry Couffinhal, Pablo Garcia-Gonzalez, Vanesa Pytel, Marta Marquié, Amanda Cano, Mercè Boada, Marc Joliot, Mark Lathrop, Quentin Le Grand, Lenore Launer, Joanna Wardlaw, Myriam Heiman, Agustin Ruiz, Paul Matthews, Sudha Seshadri, Myriam Fornage, Hieab Adams, Aniket Mishra, David-Alexandre Trégouët, Yukinori Okada, Manolis Kellis, Philip De Jager, Christophe Tzourio, Yoichiro Kamatani, Fumihiko Matsuda, Carlos Cruchaga
Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease
Cerebrovascular diseases (Basel, Switzerland)
Published

Perihaematomal Oedema Evolution over 2 Weeks after Spontaneous Intracerebral Haemorrhage and Association with Outcome: A Prospective Cohort Study

Authors
Neshika Samarasekera, Karen Ferguson, Adrian Robert Parry-Jones, Mark Rodrigues, James Loan, Tom J Moullaali, Jeremy Hughes, Laura Shoveller, Joanna Wardlaw, Barry McColl, Stuart M Allan, Magdy Selim, John Norrie, Colin Smith, Rustam Al-Shahi Salman
Perihaematomal Oedema Evolution over 2 Weeks after Spontaneous Intracerebral Haemorrhage and Association with Outcome: A Prospective Cohort Study

Wardlaw lab

Explore the work of the Wardlaw lab focused on understanding how small vessel disease damages the brain and what we can do to prevent and treat it.

Wardlaw lab
Superintendent Radiographer Charlotte Jardine and colleague examines brain scans on a computer screen