Prof Sir John Hardy

Group Leader

Harnessing genetics to build a better understanding of dementia

Condition

Alzheimer's disease, Parkinson's disease

Topics

Genetics

Biography

Prof Sir John Hardy is a world-leading neurogeneticist in the field of neurodegenerative diseases, receiving numerous accolades that include the Breakthrough Prize in Life Sciences, the Brain Prize, election as a Fellow of the Royal Society and, in 2022, a knighthood for his contributions to science and health. In 1991, Hardy's team uncovered the first mutation directly implicated in Alzheimer's disease leading to the formulation of the highly influential 'amyloid-cascade' hypothesis. His extensive body of work in genetics will be built upon in this UK DRI programme, where the team will unravel pathogenic networks in neurodegenerative disease.

News

Key publications

Nature structural & molecular biology
Published

African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1

Authors
Pilar Álvarez Jerez, Peter Wild Crea, Daniel M Ramos, Emil K Gustavsson, Mandy Radefeldt, Andrey Damianov, Mary B Makarious, Oluwadamilola O Ojo, Kimberley J Billingsley, Laksh Malik, Kensuke Daida, Sarah Bromberek, Fangle Hu, Zachary Schneider, Aditya L Surapaneni, Julia Stadler, Mie Rizig, Huw R Morris, Caroline B Pantazis, Hampton L Leonard, Laurel Screven, Yue A Qi, Mike A Nalls, Sara Bandres-Ciga, John Hardy, Henry Houlden, Celeste Eng, Esteban González Burchard, Linda Kachuri, Chia-Ho Lin, Douglas L Black, Global Parkinson’s Genetics Program (GP2), Andrew B Singleton, Steffen Fischer, Peter Bauer, Xylena Reed, Mina Ryten, Christian Beetz, Michael Ward, Njideka U Okubadejo, Cornelis Blauwendraat
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
Movement disorders : official journal of the Movement Disorder Society
Published

The ZFHX3 GGC Repeat Expansion Underlying Spinocerebellar Ataxia Type 4 has a Common Ancestral Founder

Authors
Zhongbo Chen, Pilar Alvarez Jerez, Claire Anderson, Martin Paucar, Jasmaine Lee, Daniel Nilsson, Hannah Macpherson, Annarita Scardamaglia, Kylie Montgomery, John Hardy, Andrew B Singleton, Arianna Tucci, Katherine D Mathews, Ying-Hui Fu, Martin Engvall, José Laffita-Mesa, Inger Nennesmo, Anna Wedell, Louis J Ptáček, Cornelis Blauwendraat, Emil K Gustavsson, Per Svenningsson, Mina Ryten, Henry Houlden
The ZFHX3 GGC Repeat Expansion Underlying Spinocerebellar Ataxia Type 4 has a Common Ancestral Founder
bioRxiv : the preprint server for biology
Published

Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: an improved mouse model of Alzheimer's disease without mutations in <em>MAPT</em>

Authors
Sneha Desai, Elena Camporesi, Gunnar Brinkmalm, Argyro Alatza, Jack I Wood, Takshashila Tripathi, Sumi Bez, Nazar Stasyuk, Haady B Hajar, Takashi Saito, Takaomi C Saido, John Hardy, Damian M Cummings, Jörg Hanrieder, Frances A Edwards
Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: an improved mouse model of Alzheimer's disease without mutations in <em>MAPT</em>
Nature medicine
Published

Increased frequency of repeat expansion mutations across different populations

Authors
Kristina Ibañez, Bharati Jadhav, Matteo Zanovello, Delia Gagliardi, Christopher Clarkson, Stefano Facchini, Paras Garg, Alejandro Martin-Trujillo, Scott J Gies, Valentina Galassi Deforie, Anupriya Dalmia, Davina J Hensman Moss, Jana Vandrovcova, Clarissa Rocca, Loukas Moutsianas, Chiara Marini-Bettolo, Helen Walker, Chris Turner, Maryam Shoai, Jeffrey D Long, Pietro Fratta, Douglas R Langbehn, Sarah J Tabrizi, Mark J Caulfield, Andrea Cortese, Valentina Escott-Price, John Hardy, Henry Houlden, Andrew J Sharp, Arianna Tucci
Increased frequency of repeat expansion mutations across different populations

Hardy Lab

Explore the work of the Hardy Lab, harnessing genetics to build a better understanding of dementia

 
Hardy Lab