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Molecular neurodegeneration
Published

Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis

Authors

John Hardy, Patrick Lewis

Abstract

Mol Neurodegener. 2025 May 9;20(1):55. doi: 10.1186/s13024-025-00847-8.

ABSTRACT

While APP is largely neuonally expressed, Aβ amyloid is largely produced by microglia as the clearance mechanisms for damaged membranes becomes overwhelmed.

PMID:40346674 | DOI:10.1186/s13024-025-00847-8

UK DRI Authors

John Hardy

Prof Sir John Hardy

Group Leader

Harnessing genetics to build a better understanding of dementia

Prof Sir John Hardy