Human-Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons.

Authors

Jimena Monzón-Sandoval, Ilaria Poggiolini, Tobias Ilmer, Richard Wade-Martins, Caleb Webber, Laura Parkkinen

Abstract

Neuronal loss in the substantia nigra pars compacta (SNpc) in Parkinson disease (PD) is not uniform, as dopamine neurons from the ventral tier are lost more rapidly than those of the dorsal tier. Identifying the intrinsic differences that account for this differential vulnerability may provide a key for developing new treatments for PD.

PMID:32167609 | DOI:

UK DRI Authors

Prof Caleb Webber

Director of Data Science & Group Leader

Combining state-of-the-art stem cell models with bioinformatics techniques to boost our understanding of the biological mechanisms underlying Parkinson’s disease

Prof Caleb Webber

Prof Laura Parkkinen

Group Leader

Harnessing next-generation human neuropathology to decode the mechanisms that drive Parkinson’s

Prof Laura Parkkinen