Prof Jernej Ule

Centre Director & Research Division Lead

Deciphering the role of RNA in amyotrophic lateral sclerosis and frontotemporal dementia

Condition

Alzheimer's disease, Motor neuron disease/ALS, Frontotemporal dementia

Topics

Molecular mechanisms, Biomarkers & diagnostics, Ageing, Cell biology of neurons & glia

Techniques

Genomics, Next generation sequencing, Epigenomics, Advanced spectroscopy, Single cell / nucleus transcriptomics, Advanced microscopy & imaging, Spatial transcriptomics, Bioinformatics, Biophysical techniques, CRISPR, Flow cytometry, Mass spec-based proteomics, Software development, Stem cells / iPSCs

Biography

Jernej Ule obtained his BSc in Molecular Biology from University of Ljubljana, Slovenia and then went on to complete a PhD and postdoctoral programme with Dr Robert Darnell at The Rockefeller University (New York) before starting his own research group at the MRC Laboratory of Molecular Biology (Cambridge) in July 2006. He then moved with his team to the UCL Queen Square Institute of Neurology (London) and started a secondment as a Group Leader at the Francis Crick Institute. In April 2022, Prof Ule was appointed as Director of the UK DRI at King’s, where most of his team is now located. He also maintains a joint satellite team at the Francis Crick Institute with Prof Benjamin Blencowe to conduct research funded by the Wellcome Trust.

News

Key publications

Science (New York, N.Y.)
Published
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration
Authors
Katie E Copley, Jocelyn C Mauna, Helen L Danielson, Qizan Chen, Busra Ozguney, Marilyn Ngo, Longxin Xie, Ashleigh Smirnov, Matt Davis, Leland Mayne, Miriam Linsenmeier, Jack D Rubien, Cristian A Bergmann, Bede Portz, Bo Lim Lee, Hana M Odeh, Longsheng Lai, Yi-Wei Chang, Martina Hallegger, Jernej Ule, Piera Pasinelli, Yan Poon, Jeetain Mittal, Nicolas L Fawzi, Ben E Black, Christopher J Donnelly, Brigid K Jensen, James Shorter
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration
BMC biology
Published
Correction: Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites
Authors
Nejc Haberman, Holly Digby, Rupert Faraway, Rebecca Cheung, Anob M Chakrabarti, Andrew M Jobbins, Callum Parr, Kayoko Yasuzawa, Takeya Kasukawa, Chi Wai Yip, Masaki Kato, Hazuki Takahashi, Piero Carninci, Santiago Vernia, Jernej Ule, Christopher R Sibley, Aida Martinez-Sanchez, Boris Lenhard
Correction: Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites

Ule Lab

Explore the work of the Ule Lab focused on understanding the role of RNA in amyotrophic lateral sclerosis and frontotemporal dementia.

Ule Lab
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