Skip to main content
Search
Main content

Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Alzheimer's research & therapy
Published

Glymphatic dysfunction links vascular pathology to Alzheimer's biomarkers and cognitive decline

Authors
Sung Hoon Kang, Seongmi Kim, Young Ju Kim, Heejin Yoo, Eun Hye Lee, Hyemin Jang, Daeun Shin, Jihwan Yun, Jun Pyo Kim, Hee Jin Kim, Duk L Na, Henrick Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Theresa A Day, Marco Duering, Seong-Beom Koh, Sang-Young Kim, Eung Yeop Kim, Sung Tae Kim, Beomseok Sohn, Sang Won Seo
Glymphatic dysfunction links vascular pathology to Alzheimer's biomarkers and cognitive decline
Journal of neurotrauma
Published

Alterations in CSF Amyloid-β and Tau Biomarkers in Former College and Professional American Football Players: Findings from the DIAGNOSE CTE Research Project

Authors
Deidre Jansson, Jane Shofer, Elizabeth Colasurdo, Abigail Schindler, Ge Li, Charles H Adler, Laura Balcer, Charles Bernick, Daniel Daneshvar, Douglas Katz, Michael McClean, Jesse Mez, Joseph Palmisano, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, Yorghos Tripodis, Michael L Alosco, Jeffrey L Cummings, Eric M Reiman, Martha Shenton, Robert A Stern, Jeffrey Iliff, Elaine R Peskind, DIAGNOSE CTE Research Project
Alterations in CSF Amyloid-β and Tau Biomarkers in Former College and Professional American Football Players: Findings from the DIAGNOSE CTE Research Project
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging

Authors
Wenyue Zheng, Yuanbing Jiang, Hiu Yi Wong, Wan Wa Wong, Lily K W Cheng, Elaine Y L Cheng, Bonnie W Y Wong, Ronnie M N Lo, Siu Ki Leung, Fanny C Ip, Jacqueline K Y Yuen, Yat Fung Shea, Wai Ming Wong, Chun Keung Shum, Hok Man Wai, Vincent C T Mok, Timothy C Y Kwok, Kin Y Mok, Amanda Heslegrave, John Hardy, Henrik Zetterberg, Amy K Y Fu, Nancy Y Ip
Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging
Journal of the American Heart Association
Published

Stroke, Small-Vessel Disease, and Occupation: Systematic Review and Data Analysis

Authors
Thomas Zhang, Una Clancy, Ayush Singh, Stephen Makin, Caroline McHutchison, Vera Cvoro, Carmen Arteaga-Reyes, Daniela Jaime Garcia, Will Hewins, Michael Stringer, Michael Thrippleton, Maria C Valdes-Hernandez, Stewart Wiseman, Francesca Chappell, Rosalind Brown, Fergus Doubal, Joanna M Wardlaw
Stroke, Small-Vessel Disease, and Occupation: Systematic Review and Data Analysis
European stroke journal
Published

Randomised, controlled Trial of CT perfusion and angiography compared to CT alone in thrombolysis-eligible acute ischaemic stroke patients: The penumbra and recanalisation acute computed tomography in ischaemic stroke evaluation (PRACTISE) trial

Authors
Keith W Muir, Salwa El Tawil, Alex McConnachie, Ian Ford, Grant Mair, Jattinder Khaira, Kausik Chatterjee, Laszlo Sztriha, Omid Halse, Ibrahim Balogun, Sanjeev Nayak, Phil White, Elizabeth A Warburton, Joanna Wardlaw
Randomised, controlled Trial of CT perfusion and angiography compared to CT alone in thrombolysis-eligible acute ischaemic stroke patients: The penumbra and recanalisation acute computed tomography in ischaemic stroke evaluation (PRACTISE) trial
European stroke journal
Published

Stroke Action Plan for Europe 2018-2030 (SAP-E): mid-term review and update

Authors
Hanne Christensen, Francesca Romana Pezzella, Melinda Berg Roaldsen, Aleš Tomek, Arlene Wilkie, Louisa Christensen, Martin Dichgans, Avril Drummond, Tiina Laatikainen, Carlos A Molina, Katharina S Sunnerhagen, Danilo Toni, Sonia Abilleira, Diana Aguiar de Sousa, Anita Arsovska, Heinrich Audebert, Jelena Bartolovic, Yannick Béjot, Geert Jan Biessels, Juliet Bouverie, Hrvoje Budincevic, Barbara Casolla, Hugues Chabriat, Marina Charalambous, Jesse Dawson, Stephanie Debette, Frank-Erik de Leeuw, Adam Denes, Marina Diomedi, Diederik Dippel, Ulrich Dirnagl, Urs Fischer, Yuriy Flomin, Ana Catarina Fonseca, Birgitte Forchammer, Anne Forster, Giovanni Frisullo, Miquel Galofre, Zuzana Gdovinová, Christoph Gumbinger, Joseph Harbison, Richard Hobbs, Dalius Jatuzis, Hrvoje Jurlina, Mira Katan, Lisa Kidd, Stefan Kiechl, Janika Kõrv, Christina Kruuse, Wilfried Lang, Arthur Liesz, Svetlana Lorenzano, Andreas Luft, Grethe Lunde, Chris Macey, Hugh Stephan Markus, Gillian Mead, Patrik Michel, Serefnur Ozturk, Maurizio Paciaroni, Aleksandra Pavlovic, Carina U Persson, Terence J Quinn, Peter Rothwell, Luca Saba, Paola Santalucia, Gustavo Santo, Claus Simonsen, Thorsten Steiner, Katarzyna Stolarz-Skrzypek, Cristina Tiu, Alexander Tsiskaridze, Georgios Tsivgoulis, Jaakko Tuomilehto, Teresa Ulberg, Paolo Ursillo, Antonella Urso, Mia van Euler, Margus Viigimaa, Denis Vivien, Markus Wagner, Marion Walker, Alastair Webb, Diana Wong Ramos, Mauro Zampolini, Marialuisa Zedde, Gary Ford, Peter Kelly, Robert Mikulik, Bo Norrving, Hariklia Proios, Simona Sacco, Else Sandset, Joanna Wardlaw, Aleksandras Vilionskis, Valeria Caso
Stroke Action Plan for Europe 2018-2030 (SAP-E): mid-term review and update
Brain, behavior, and immunity
Published

Higher CSF sTREM2 is related to slower hippocampal atrophy and cognitive decline independently of pTau181 levels

Authors
Henry Gilreath Stephenson, Tobey J Betthauser, Erin Jonaitis, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Michael Ewers, Jannis Denecke, Tyler K Ulland, Nathaniel A Chin, Ozioma C Okonkwo, Cynthia M Carlsson, Sanjay Asthana, Sterling C Johnson, Kaj Blennow, Henrik Zetterberg, Barbara B Bendlin
Higher CSF sTREM2 is related to slower hippocampal atrophy and cognitive decline independently of pTau181 levels
Nature
Published

Intestinal macrophages modulate synucleinopathy along the gut-brain axis

Authors
Sebastiaan De Schepper, Viktoras Konstantellos, James A Conway, Dimitra Sokolova, Ludovica Zaccagnini, Matthew V Cowley, Annerieke Sierksma, Maria Yudina, Marisa Edmonds, Daria Gavriouchkina, Bethany Geary, Amber Wallis, Meral Celikag, Zeynep Baykam, Mónica Vara-Pérez, Gerard Crowley, Fabian Tobias Hager, Mitchell Bijnen, David Posner, Kelvin Luk, Vuk Cerovic, Menna Clatworthy, Elizabeth J Videlock, Zane Jaunmuktane, Kiavash Movahedi, Melanie Greter, Benny Chain, Dario R Alessi, Soyon Hong, Tim Bartels
Intestinal macrophages modulate synucleinopathy along the gut-brain axis
Immunology
Published

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID

Authors
Samuel B K Keat, Priyanka Khatri, Youssif M Ali, Chanuka H Arachchilage, Gregory Demopulos, Kirsten Baillie, Kelly L Miners, Kristin Ladell, Samantha A Jones, Helen E Davies, David A Price, Wioleta M Zelek, B Paul Morgan, Wilhelm J Schwaeble, Nicholas J Lynch
Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published

The Mitochondrial Guardian α-Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK-SARM1-ULK1 Axis

Authors
Shu-Qin Cao, Juan Ignacio Jiménez-Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E Smith, Junjie Huang, Jun-Ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F Fang
The Mitochondrial Guardian α-Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK-SARM1-ULK1 Axis
The journal of prevention of Alzheimer's disease
Published

Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease

Authors
Claude M Wischik, Richard Stefanacci, Peter Bentham, Serge Gauthier, Henrik Zetterberg, Gordon K Wilcock, Lutz Froelich, Alistair Burns, Emer MacSweeney, Clive Ballard, Jin-Tai Yu, Tay Siew Choon, Vahe Asvatourian, Natalia Muehlemann, Jan Priel, Karin Kook, Tenecia Sullivan, Diane Downie, Sonya Miller, Carol Pringle, John M D Storey, Tom Baddeley, Charles R Harrington, Lewis K Penny, Mohammad Arastoo, Roger Staff, Anca-Larisa Sandu, Helen Shiells, Serena Lo, Nafeesa Nazlee, Emily Evans, Claire Hull, Bjoern O Schelter
Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease
BMC research notes
Published

Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort

Authors
Sarah E Keuss, Kirsty Lu, Sarah-Naomi James, Jennifer M Nicholas, William Coath, Ashvini Keshavan, David M Cash, Carole H Sudre, Josephine Barnes, Heidi Murray-Smith, Andrew Wong, Rebecca Street, Marcus Richards, Jonathan M Schott
Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort
Computer methods and programs in biomedicine
Published

Shape matters: Predicting Huntington's disease using progression modelling

Authors
Mohsen Ghofrani-Jahromi, Susmita Saha, Adeel Razi, Pubu M Abeyasinghe, Govinda R Poudel, Jane S Paulsen, Sarah J Tabrizi, Nellie Georgiou-Karistianis
Shape matters: Predicting Huntington's disease using progression modelling