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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Brain : a journal of neurology
Published

Disease-modifying effects of TMEM106B in genetic frontotemporal dementia: a longitudinal GENFI study

Authors
Saira S Mirza, Maurice Pasternak, Andrew D Paterson, Ekaterina Rogaeva, Maria C Tartaglia, Sara B Mitchell, Sandra E Black, Morris Freedman, David Tang-Wai, Arabella Bouzigues, Lucy L Russell, Phoebe H Foster, Eve Ferry-Bolder, Martina Bocchetta, David M Cash, Henrik Zetterberg, Aitana Sogorb-Esteve, John van Swieten, Lize C Jiskoot, Harro Seelaar, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Sandro Sorbi, Markus Otto, Florence Pasquier, Simon Ducharme, Chris Butler, Isabelle Le Ber, Elizabeth Finger, James B Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Jonathan D Rohrer, Mario Masellis, GENetic Frontotemporal dementia Initiative (GENFI)
Disease-modifying effects of TMEM106B in genetic frontotemporal dementia: a longitudinal GENFI study
Journal of Alzheimer's disease : JAD
Published

A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans

Authors
Devesh Singh, Alice Grazia, Achim Reiz, Andreas Hermann, Slawek Altenstein, Lukas Beichert, Alexander Bernhardt, Katharina Buerger, Michaela Butryn, Peter Dechent, Emrah Duezel, Michael Ewers, Klaus Fliessbach, Silka D Freiesleben, Wenzel Glanz, Stefan Hetzer, Daniel Janowitz, Ingo Kilimann, Okka Kimmich, Christoph Laske, Johannes Levin, Andrea Lohse, Falk Luesebrink, Matthias Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Johannes Prudlo, Boris S Rauchmann, Ayda Rostamzadeh, Nina Roy-Kluth, Klaus Scheffler, Anja Schneider, Luisa S Schneider, Björn H Schott, Annika Spottke, Eike J Spruth, Matthis Synofzik, Jens Wiltfang, Frank Jessen, Stefan J Teipel, Martin Dyrba, ADNI, AIBL, FTLDNI, study groups
A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans
Acta neuropathologica
Published

Correction: CSF p-tau205: a biomarker of tau pathology in Alzheimer's disease

Authors
Juan Lantero-Rodriguez, Laia Montoliu-Gaya, Andrea L Benedet, Agathe Vrillon, Julien Dumurgier, Emmanuel Cognat, Wagner S Brum, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Bruno Becker, Gunnar Brinkmalm, Anniina Snellman, Hanna Huber, Hlin Kvartsberg, Nicholas J Ashton, Henrik Zetterberg, Claire Paquet, Pedro Rosa-Neto, Kaj Blennow
Correction: CSF p-tau205: a biomarker of tau pathology in Alzheimer's disease
Molecular psychiatry
Published

Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease

Authors
David Mengel, Ester Soter, Julia Maren Ott, Madeleine Wacker, Alejandra Leyva, Oliver Peters, Julian Hellmann-Regen, Luisa-Sophie Schneider, Xiao Wang, Josef Priller, Eike Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Niels Hansen, Ayda Rostamzadeh, Emra Düzel, Wenzel Glanz, Enise I Incesoy, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Sebastian Sodenkamp, Annika Spottke, Johanna Brustkern, Frederic Brosseron, Michael Wagner, Melina Stark, Luca Kleineidam, Kai Shao, Falk Lüsebrink, Renat Yakupov, Matthias Schmid, Stefan Hetzer, Peter Dechent, Klaus Scheffler, David Berron, Frank Jessen, Matthis Synofzik, DELCODE study group
Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease
EBioMedicine
Published

Dissection of blood-brain barrier dysfunction through CSF PDGFRβ and amyloid, tau, neuroinflammation, and synaptic CSF biomarkers in neurodegenerative disorders

Authors
Agathe Vrillon, Nicholas J Ashton, Elodie Bouaziz-Amar, François Mouton-Liger, Emmanuel Cognat, Julien Dumurgier, Matthieu Lilamand, Thomas K Karikari, Vincent Prevot, Henrik Zetterberg, Kaj Blennow, Claire Paquet
Dissection of blood-brain barrier dysfunction through CSF PDGFRβ and amyloid, tau, neuroinflammation, and synaptic CSF biomarkers in neurodegenerative disorders
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

The CentiMarker project: Standardizing quantitative Alzheimer's disease fluid biomarkers for biologic interpretation

Authors
Guoqiao Wang, Yan Li, Chengjie Xiong, Yuchen Cao, Suzanne E Schindler, Eric McDade, Kaj Blennow, Oskar Hansson, Jeffrey L Dage, Clifford R Jack, Charlotte E Teunissen, Leslie M Shaw, Henrik Zetterberg, Laura Ibanez, Jigyasha Timsina, Cruchaga Carlos, Alzheimer's Disease Neuroimaging Initiative, Randall J Bateman
The CentiMarker project: Standardizing quantitative Alzheimer's disease fluid biomarkers for biologic interpretation
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease

Authors
Emre Fertan, Jeff Y L Lam, Giulia Albertini, Maarten Dewilde, Yunzhao Wu, Oluwatomi E S Akingbade, Dorothea Böken, Elizabeth A English, Bart De Strooper, David Klenerman
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease
Brain : a journal of neurology
Published

Intronic FGF14 GAA repeat expansions impact progression and survival in multiple system atrophy

Authors
Viorica Chelban, David Pellerin, Nirosen Vijiaratnam, Hamin Lee, Yen Yee Goh, Lauren Brown, Sara Sambin, Danielle Seilhean, Stephane Lehericy, Pablo Iruzubieta, Rahema Mohammad, Eleanor Self, Annarita Scardamaglia, Cameron Lee, Miriama Ostrozovicova, Marie-Josée Dicaire, Christine Girges, Emil K Gustavsson, David Murphy, Toby Curless, Joshua Laβ, Joanne Trinh, Timothy Rittman, James B Rowe, Marios Hadjivassiliou, Neil Archibald, Matt C Danzi, Catherine Ashton, Virginie Roth, Marion Wandzel, Warren A Cheung, Djordje O Gveric, Bart De Vil, Jordan Follett, P Nigel Leigh, Lukas Beichert, Tomi Pastinen, Céline Bonnet, Mathilde Renaud, Wassilios G Meissner, Anne Sieben, David Crosiers, Patrick Cras, Stephan Zuchner, Jean-Christophe Corvol, Matthew J Farrer, Matthis Synofzik, Bernard Brais, Tom Warner, Huw R Morris, Zane Jaunmuktane, Tom Foltynie, Henry Houlden
Intronic FGF14 GAA repeat expansions impact progression and survival in multiple system atrophy
Cell reports methods
Published

Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community

Authors
Takahiro Morito, Mohan Qi, Naoko Kamano, Hiroki Sasaguri, Sumi Bez, Martha Foiani, Karen Duff, Seico Benner, Toshihiro Endo, Hiroshi Hama, Hiroshi Kurokawa, Atushi Miyawaki, Hiroshi Mizuma, Naruhiko Sahara, Masafumi Shimojo, Makoto Higuchi, Takaomi C Saido, Naoto Watamura
Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community