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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Movement disorders : official journal of the Movement Disorder Society
Published

Identification of GGC Repeat Expansions in ZFHX3 among Chilean Movement Disorder Patients

Authors
Paula Saffie-Awad, Abraham Moller, Kensuke Daida, Pilar Alvarez Jerez, Zhongbo Chen, Zachary B Anderson, Mariam Isayan, Kimberly Paquette, Sophia B Gibson, Madison Fulcher, Abigail Miano-Burkhardt, Laksh Malik, Breeana Baker, Paige Jarreau, Henry Houlden, Mina Ryten, Bida Gu, Mark J P Chaisson, Danny E Miller, Pedro Chaná-Cuevas, Cornelis Blauwendraat, Andrew B Singleton, Kimberley J Billingsley
Identification of GGC Repeat Expansions in ZFHX3 among Chilean Movement Disorder Patients
Scientific reports
Published

Synaptic markers are associated with cognitive decline after accounting for amyloid burden among an at-risk Alzheimer's disease cohort

Authors
Elizabeth M Planalp, Rebecca E Langhough, Erin M Jonaitis, Carol A Van Hulle, Rachael E Wilson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Ozioma C Okonkwo, Barbara B Bendlin, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C Johnson
Synaptic markers are associated with cognitive decline after accounting for amyloid burden among an at-risk Alzheimer's disease cohort
Science advances
Published

Proteomic signatures of corona and herpes viral antibodies identify IGDCC4 as a mediator of neurodegeneration

Authors
Michael R Duggan, Shuojia Yang, Gabriela T Gomez, Yuhan Cui, Ana W Capuano, Jingsha Chen, Zhijian Yang, Junhao Wen, Guray Erus, Shannon M Drouin, David Zweibaum, Qu Tian, Julián Candia, Murat Bilgel, Alexandria Lewis, Abhay Moghekar, Nicholas J Ashton, Przemysław R Kac, Thomas K Karikari, Kaj Blennow, Henrik Zetterberg, Brion S Maher, Adam P Spira, Logan Dumitrescu, Timothy J Hohman, Rebecca F Gottesman, Christos Davatzikos, David A Bennett, Josef Coresh, Luigi Ferrucci, Susan M Resnick, Robert Yolken, Keenan A Walker
Proteomic signatures of corona and herpes viral antibodies identify IGDCC4 as a mediator of neurodegeneration
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference

Authors
Bess Frost, James B Rowe, Rufus O Akinyemi, Jose F Abisambra, Nicholas J Ashton, Matthias Brendel, Luc Buée, David Butler, Maria C Carrillo, Peter Chung, Claire D Clelland, Sarah L DeVos, Kristophe Diaz, Rebecca M Edelmayer, Fanny M Elahi, Ratnavalli Ellajosyula, Colin Ewen, Igor Camargo Fontana, Marie-Christine Galas, Oskar Hansson, Günter Höglinger, Kanta Horie, Agustín Ibanez, Linde Jacobs, Mahmoud B Maina, Maura Malpetti, Eric McDade, Will McEwan, Laia Montoliu-Gaya, Catherine J Mummery, Miranda E Orr, Jonathan D Rohrer, Amy Rommel, Carlos Sastre, Tara L Spires-Jones, Boon Lead Tee, Tim J Viney, Jamie M Walker, Susanne Wegmann, Kristin Wildsmith, Ravi Yadav, Simin Mahinrad, Claire Sexton
Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Repeated plasma p-tau217 measurements to monitor clinical progression heterogeneity

Authors
Bjørn-Eivind Kirsebom, Fernando Gonzalez-Ortiz, Sinthujah Vigneswaran, Geir Bråthen, Ragnhild Eide Skogseth, Berglind Gísladóttir, Peter Harrison, Jonas Alexander Jarholm, Lene Pålhaugen, Arvid Rongve, Per Selnes, Betty Tjims, Michael Turton, Argonde C Van Harten, Knut Waterloo, Henrik Zetterberg, Tormod Fladby, Kaj Blennow
Repeated plasma p-tau217 measurements to monitor clinical progression heterogeneity
Neurology
Published

Association of Self-Reported Sleep Metrics With Imaging Markers of Small Vessel Disease and Cognition in Patients With TIA or Mild Stroke

Authors
Dillys Xiaodi Liu, Mary Sau-Man Ip, David Chi-Leung Lam, Francesca M Chappell, Una Clancy, Daniela Jaime Garcia, Carmen Arteaga-Reyes, Maria Del C Valdés Hernández, Michael Thrippleton, Michael S Stringer, Yajun Cheng, Junfang Zhang, Fergus Doubal, Gary Kui Kai Lau, Joanna M Wardlaw
Association of Self-Reported Sleep Metrics With Imaging Markers of Small Vessel Disease and Cognition in Patients With TIA or Mild Stroke
JMIR aging
Published

Longitudinal Remote Sleep and Cognitive Research in Older Adults With Mild Cognitive Impairment and Dementia: Prospective Feasibility Cohort Study

Authors
Victoria Grace Gabb, Jonathan Blackman, Hamish Morrison, Haoxuan Li, Adrian Kendrick, Nicholas Turner, Rosemary Greenwood, Bijetri Biswas, Amanda Heslegrave, Elizabeth Coulthard
Longitudinal Remote Sleep and Cognitive Research in Older Adults With Mild Cognitive Impairment and Dementia: Prospective Feasibility Cohort Study
Nature communications
Published

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease

Authors
Kitty B Murphy, Di Hu, Leen Wolfs, Susan K Rohde, Gonzalo Leguía Fauró, Ivana Geric, Renzo Mancuso, Bart De Strooper, Sarah J Marzi
The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease
Brain communications
Published

Evidence that minocycline treatment confounds the interpretation of neurofilament as a biomarker

Authors
Juliana E Gentile, Christina N Heiss, Taylor L Corridon, Meredith A Mortberg, Stefanie Fruhwürth, Kenia Guzman, Lana Grötschel, Laia Montoliu-Gaya, Kwan Chan, Neil C Herring, Timothy Janicki, Rajaa Nhass, Janani Manavala Sarathy, Brian Erickson, Ryan Kunz, Alison Erickson, Craig Braun, Katherine T Henry, Lynn Bry, Steven E Arnold, Eric Vallabh Minikel, Henrik Zetterberg, Sonia M Vallabh
Evidence that minocycline treatment confounds the interpretation of neurofilament as a biomarker
EBioMedicine
Published

A plasma biomarker panel for detecting early amyloid-β accumulation and its changes in middle-aged cognitively unimpaired individuals at risk for Alzheimer's disease

Authors
Armand González-Escalante, Marta Milà-Alomà, Wagner S Brum, Nicholas J Ashton, Paula Ortiz-Romero, Mahnaz Shekari, Marta Del Campo, Federica Anastasi, Clara Quijano-Rubio, Gwendlyn Kollmorgen, Carolina Minguillón, Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, Juan Domingo Gispert, Henrik Zetterberg, Natalia Vilor-Tejedor, Kaj Blennow, Marc Suárez-Calvet
A plasma biomarker panel for detecting early amyloid-β accumulation and its changes in middle-aged cognitively unimpaired individuals at risk for Alzheimer's disease