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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Science advances
Published

Astrocytic RNA editing regulates the host immune response to alpha-synuclein

Authors
Karishma D'Sa, Minee L Choi, Aaron Z Wagen, Núria Setó-Salvia, Olga Kopach, James R Evans, Margarida Rodrigues, Patricia Lopez-Garcia, Joanne Lachica, Benjamin E Clarke, Jaijeet Singh, Ali Ghareeb, James Bayne, Melissa Grant-Peters, Sonia Garcia-Ruiz, Zhongbo Chen, Samuel Rodriques, Dilan Athauda, Emil K Gustavsson, Sarah A Gagliano Taliun, Christina Toomey, Regina H Reynolds, George Young, Stephanie Strohbuecker, Thomas Warner, Dmitri A Rusakov, Rickie Patani, Clare Bryant, David A Klenerman, Sonia Gandhi, Mina Ryten
Astrocytic RNA editing regulates the host immune response to alpha-synuclein
Neuroimaging clinics of North America
Published

Avenues in the Analysis of Enlarged Perivascular Spaces Quantified from Brain Magnetic Resonance Images Acquired at 1.5T and 3T Magnetic Field Strengths

Authors
Maria C Valdés Hernández, Roberto Duarte Coello, Alexandra Morozova, John McFadden, Charlotte Jardine, Gayle Barclay, Donna McIntyre, Francesca M Chappell, Michael Stringer, Michael J Thrippleton, Joanna M Wardlaw
Avenues in the Analysis of Enlarged Perivascular Spaces Quantified from Brain Magnetic Resonance Images Acquired at 1.5T and 3T Magnetic Field Strengths
Nature communications
Published

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau

Authors
Diana Acosta Ingram, Emir Turkes, Tae Yeon Kim, Sheeny Vo, Nicholas Sweeney, Marie-Amandine Bonte, Ryan Rutherford, Dominic L Julian, Meixia Pan, Jacob Marsh, Andrea R Argouarch, Min Wu, Douglas W Scharre, Erica H Bell, Lawrence S Honig, Jean Paul Vonsattel, Geidy E Serrano, Thomas G Beach, Celeste M Karch, Aimee W Kao, Mark E Hester, Xianlin Han, Hongjun Fu
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
Cell reports
Published

Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation

Authors
Dunxin Shen, Alec Vincent, Evan Udine, Yazead Buhidma, Sharifah Anoar, Elli Tsintzas, Marie Maeland, Dongwei Xu, Mireia Carcolé, David Osumi-Sutherland, Benjamin Aleyakpo, Alexander Hull, Guillermo Martínez Corrales, Nathan Woodling, Rosa Rademakers, Adrian M Isaacs, Carlo Frigerio, Marka van Blitterswijk, Tammaryn Lashley, Teresa Niccoli
Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation
Nature medicine
Published

Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform

Authors
Sebastian Palmqvist, Noëlle Warmenhoven, Federica Anastasi, Andrea Pilotto, Shorena Janelidze, Pontus Tideman, Erik Stomrud, Niklas Mattsson-Carlgren, Ruben Smith, Rik Ossenkoppele, Kübra Tan, Anna Dittrich, Ingmar Skoog, Henrik Zetterberg, Virginia Quaresima, Chiara Tolassi, Kina Höglund, Duilio Brugnoni, Albert Puig-Pijoan, Aida Fernández-Lebrero, José Contador, Alessandro Padovani, Mark Monane, Philip B Verghese, Joel B Braunstein, Silke Kern, Kaj Blennow, Nicholas J Ashton, Marc Suárez-Calvet, Oskar Hansson
Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform
Acta neuropathologica
Published

Seeding-competent early tau multimers are associated with cell type-specific transcriptional signatures

Authors
Rahel Feleke, Simona Jogaudaite, Elisavet Velentza-Almpani, Leung Yeung-Yeung, Daniel Clode, Jeong Hun Ko, Ben Shin, Steve Matthews, Maria Otero-Jimenez, Marcelina J Wojewska, Sandra Gray-Rodriguez, Sarah J Marzi, Maxwell P Spires-Jones, Tara L Spires-Jones, Michael R Johnson, Javier Alegre-Abarrategui
Seeding-competent early tau multimers are associated with cell type-specific transcriptional signatures
Nature communications
Published

A blood- and brain-based EWAS of smoking

Authors
Aleksandra D Chybowska, Elena Bernabeu, Paul Yousefi, Matthew Suderman, Robert F Hillary, Richard Clark, Louise MacGillivray, Lee Murphy, Sarah E Harris, Janie Corley, Archie Campbell, Tara L Spires-Jones, Daniel L McCartney, Simon R Cox, Jackie F Price, Kathryn L Evans, Riccardo E Marioni
A blood- and brain-based EWAS of smoking
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Modified titration of donanemab reduces ARIA risk and maintains amyloid reduction

Authors
Hong Wang, Emel Serap Monkul Nery, Paul Ardayfio, Rashna Khanna, Diana Otero Svaldi, Ivelina Gueorguieva, Sergey Shcherbinin, Scott W Andersen, Paula M Hauck, Staci E Engle, Dawn A Brooks, Emily C Collins, Nick C Fox, Steven M Greenberg, Stephen Salloway, Mark A Mintun, John R Sims
Modified titration of donanemab reduces ARIA risk and maintains amyloid reduction