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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Molecular neurodegeneration
Published

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis

Authors
Oliver J Ziff, Gustavo Morrone Parfitt, Sarah Jolly, Jackie M Casey, Lucy Granat, Satinder Samra, Núria Setó-Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, Philippe Ravassard, Marie-Claude Potier, John Hardy, Dervis A Salih, Paul Whiting, Fiona Ducotterd, Rickie Patani, Selina Wray, Charles Arber
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis
Annals of neurology
Published

Timing of Changes in Alzheimer's Disease Plasma Biomarkers as Assessed by Amyloid and Tau PET Clocks

Authors
Marta Milà-Alomà, Duygu Tosun, Suzanne E Schindler, Isabella Hausle, Kellen K Petersen, Yan Li, Jeffrey L Dage, Lei Du-Cuny, Ziad S Saad, Benjamin Saef, Gallen Triana-Baltzer, David L Raunig, Janaky Coomaraswamy, Michael Baratta, Emily A Meyers, Yulia Mordashova, Carrie E Rubel, Kyle Ferber, Hartmuth Kolb, Nicholas J Ashton, Henrik Zetterberg, Erin G Rosenbaugh, Martin Sabandal, Leslie M Shaw, Anthony W Bannon, William Z Potter, Alzheimer's Disease Neuroimaging Initiative (ADNI), Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer's Disease Project Team
Timing of Changes in Alzheimer's Disease Plasma Biomarkers as Assessed by Amyloid and Tau PET Clocks
Journal of Alzheimer's disease : JAD
Published

Postoperative changes in ventricular cerebrospinal fluid biomarkers with correlation to clinical outcome in idiopathic normal pressure hydrocephalus

Authors
Rebecca Grønning, Anna Jeppsson, Per Hellström, Kerstin Andrén, Katarina Laurell, Dan Farahmand, Henrik Zetterberg, Kaj Blennow, Carsten Wikkelsø, Mats Tullberg
Postoperative changes in ventricular cerebrospinal fluid biomarkers with correlation to clinical outcome in idiopathic normal pressure hydrocephalus
Stroke
Published

Arterial, Venous, and Cerebrospinal Fluid Flow and Pulsatility in Stroke-Related Cerebral Small Vessel Disease: A Longitudinal Analysis

Authors
Alasdair G Morgan, Michael J Thrippleton, Michael S Stringer, Francesca M Chappell, Maria C Valdés-Hernández, Stewart Wiseman, Lucia Ballerini, Rosalind Brown, Yajun Cheng, Xiaodi Liu, Junfang Zhang, Eleni Sakka, Daniela Jamie Garcia, Emilie Sleight, Cameron Manning, Roberto D Coello, Dominic Job, Angela Jochems, Carmen Arteaga, Una Clancy, Ian Marshall, Fergus N Doubal, Joanna M Wardlaw
Arterial, Venous, and Cerebrospinal Fluid Flow and Pulsatility in Stroke-Related Cerebral Small Vessel Disease: A Longitudinal Analysis
Nature genetics
Published

Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

Authors
Aude Nicolas, Richard Sherva, Benjamin Grenier-Boley, Yoontae Kim, Masataka Kikuchi, Jigyasha Timsina, Itziar de Rojas, María Carolina Dalmasso, Xiaopu Zhou, Yann Le Guen, Carlos E Arboleda-Bustos, Maria Aparecida Camargos Bicalho, Maëlenn Guerchet, Sven van der Lee, Monica Goss, Atahualpa Castillo, Céline Bellenguez, Fahri Küçükali, Claudia L Satizabal, Bernard Fongang, Qiong Yang, Oliver Peters, Anja Schneider, Martin Dichgans, Dan Rujescu, Norbert Scherbaum, Jürgen Deckert, Steffi Riedel-Heller, Lucrezia Hausner, Laura Molina-Porcel, Emrah Düzel, Timo Grimmer, Jens Wiltfang, Stefanie Heilmann-Heimbach, Susanne Moebus, Thomas Tegos, Nikolaos Scarmeas, Oriol Dols-Icardo, Fermin Moreno, Jordi Pérez-Tur, María J Bullido, Pau Pastor, Raquel Sánchez-Valle, Victoria Álvarez, Han Cao, Nancy Y Ip, Amy K Y Fu, Fanny C F Ip, Natividad Olivar, Carolina Muchnik, Carolina Cuesta, Lorenzo Campanelli, Patricia Solis, Daniel Gustavo Politis, Silvia Kochen, Luis Ignacio Brusco, Mercè Boada, Pablo García-González, Raquel Puerta, Pablo Mir, Luis M Real, Gerard Piñol-Ripoll, Jose María García-Alberca, Jose Luís Royo, Eloy Rodriguez-Rodriguez, Hilkka Soininen, Sami Heikkinen, Alexandre de Mendonça, Shima Mehrabian, Latchezar Traykov, Jakub Hort, Martin Vyhnalek, Katrine Laura Rasmussen, Jesper Qvist Thomassen, Yolande A L Pijnenburg, Henne Holstege, John C van Swieten, Harro Seelaar, Jurgen A H R Claassen, Willemijn J Jansen, Inez Ramakers, Frans Verhey, Aad van der Lugt, Philip Scheltens, Jenny Ortega-Rojas, Ana Gabriela Concha Mera, Maria F Mahecha, Rodrigo Pardo, Gonzalo Arboleda, Shahram Bahrami, Vera Fominykh, Geir Selbæk, Caroline Graff, Goran Papenberg, Vilmantas Giedraitis, Anne Boland, Jean-François Deleuze, Luiz Armando de Marco, Edgar Nunes de Moraes, Bernardo de Mattos Viana, Marco Túlio Gualberto Cintra, Teresa Juarez-Cedillo, Anthony J Griswold, Tatiana Forund, Jonathan Haines, Lindsay Farrer, Anita DeStefano, Ellen Wijsman, Richard Mayeux, Margaret Pericak-Vance, Brian Kunkle, Alison Goate, Gerard D Schellenberg, Badri Vardarajan, Li-San Wang, Yuk Yee Leung, Clifton L Dalgard, Gael Nicolas, David Wallon, Carole Dufouil, Florence Pasquier, Olivier Hanon, Stéphanie Debette, Edna Grünblatt, Julius Popp, Bárbara Angel, Sergio Gloger, Maria Victoria Chacon, Rafael Aranguiz, Paulina Orellana, Andrea Slachevsky, Christian Gonzalez-Billault, Cecilia Albala, Patricio Fuentes, Perminder Sachdev, Karen A Mather, Richard L Hauger, Victoria Merritt, Matthew Panizzon, Rui Zhang, J Michael Gaziano, Roberta Ghidoni, Daniela Galimberti, Beatrice Arosio, Patrizia Mecocci, Vincenzo Solfrizzi, Lucilla Parnetti, Alessio Squassina, Lucio Tremolizzo, Barbara Borroni, Benedetta Nacmias, Paolo Caffarra, Davide Seripa, Innocenzo Rainero, Antonio Daniele, Fabrizio Piras, EADB, Hampton L Leonard, Jenifer S Yokoyama, Mike A Nalls, Akinori Miyashita, Norikazu Hara, Kouichi Ozaki, Shumpei Niida, Julie Williams, Carlo Masullo, Philippe Amouyel, Pierre-Marie Preux, Pascal Mbelesso, Bébène Bandzouzi, Andy Saykin, Frank Jessen, Patrick G Kehoe, Cornelia Van Duijn, Nesrine Ben Salem, Ruth Frikke-Schmidt, Lotfi Cherni, Michael D Greicius, Magda Tsolaki, Pascual Sánchez-Juan, Marco Aurélio Romano Silva, Tenielle Porter, Simon M Laws, Kristel Sleegers, Martin Ingelsson, Jean-François Dartigues, Sudha Seshadri, Giacomina Rossi, Laura Morelli, Mikko Hiltunen, Rebecca Sims, Wiesje van der Flier, Ole A Andreassen, Humberto Arboleda, Carlos Cruchaga, Valentina Escott-Price, Agustín Ruiz, Kun Ho Lee, Takeshi Ikeuchi, Alfredo Ramirez, Jungsoo Gim, Mark Logue, Jean-Charles Lambert
Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
BMJ open
Published

Carbon footprint of a sample of clinical trials for people with neurological disorders: cross-sectional analysis

Authors
Denise Cranley, Sarah Dunn, John-Paul Taylor, Michael Jr Desborough, Jennifer Craig, Nikola Sprigg, Rachel McComish, Thomas Foltynie, Joanna Wardlaw, Katherine Oatey, Anna Heye, Philip Bath, Karen Innes, Lynn Dinsmore, Jessica Griffiths, Lisa Fox, Paula R Williamson, Rustam Al-Shahi Salman
Carbon footprint of a sample of clinical trials for people with neurological disorders: cross-sectional analysis
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome

Authors
Mathias Sauer, Bárbara Fernandes Gomes, Parasto Shahrouki, Juan Lantero-Rodriguez, Laia Montoliu-Gaya, Elena Camporesi, Olivia Belbin, Daniel Alcolea, Ashish Kumar, Mitu Sharma, Sangeeta Singh, Gunnar Brinkmalm, Johan Gobom, María Carmona-Iragui, Michael Schöll, Shorena Janelidze, Gagan Deep, Kaj Blennow, Henrik Zetterberg, Ann Brinkmalm, Alberto Lleó, Juan Fortea, Oskar Hansson, Nicholas J Ashton, Johanna Nilsson
Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome
Nature nanotechnology
Published

Nanoneedles enable spatiotemporal lipidomics of living tissues

Authors
Chenlei Gu, Davide Alessandro Martella, Leor Ariel Rose, Nadia Rouatbi, Cong Wang, Alaa Zam, Valeria Caprettini, Magnus Jensen, Shiyue Liu, Cathleen Hagemann, Siham Memdouh, Andrea Serio, Vincenzo Abbate, Khuloud T Al-Jamal, Maddy Parsons, Mads S Bergholt, Paul M Brennan, Assaf Zaritsky, Ciro Chiappini
Nanoneedles enable spatiotemporal lipidomics of living tissues
JAMA
Published

Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity

Authors
Alexis Moscoso, Fiona Heeman, Sheelakumari Raghavan, Alejandro Costoya-Sánchez, Martijn van Essen, Ismini Mainta, Valle Camacho, Omar Rodríguez-Fonseca, Jesús Silva-Rodríguez, Andrés Perissinotti, Yuna Gu, Jihwan Yun, Debora Peretti, Federica Ribaldi, Emma M Coomans, Wagner S Brum, Michel J Grothe, Pablo Aguiar, Gérard N Bischof, Alexander Drzezga, Sang Won Seo, Sylvia Villeneuve, Maura Malpetti, John T O'Brien, James B Rowe, Elsmarieke M van de Giessen, Rik Ossenkoppele, William J Jagust, Ruben Smith, Oskar Hansson, Giovanni B Frisoni, Valentina Garibotto, David N Soleimani-Meigooni, Maria Carrillo, Bradford C Dickerson, Renaud La Joie, Gil D Rabinovici, Liana G Apostolova, Pamela J LaMontagne, Michael J Pontecorvo, Keith A Johnson, Reisa A Sperling, Michael W Weiner, Ronald C Petersen, Clifford R Jack, Prashanthi Vemuri, Michael Schöll, PREVENT-AD Research Group, the Harvard Aging Brain Study, the LEADS Consortium, and the Alzheimer’s Disease Neuroimaging Initiative
Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity
Cell reports
Published

The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo

Authors
Samuel S Harris, Rikesh M Rajani, Jana Zünkler, Robert Ellingford, Mengke Yang, James M Rowland, Alexander Schmidt, Byung Il Lee, Marten Kehring, Mariam Hellmuth, Francesca Kar Wey Lam, Dominique Fässler, Susanne Erdinger, David P Wolfer, Carlo Sala Frigerio, Fred Wolf, Bradley T Hyman, Ulrike C Müller, Marc Aurel Busche
The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo
bioRxiv : the preprint server for biology
Published

Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology

Authors
Vaibhav Vemuganti, Jea Woo Kang, Qijun Zhang, Ruben Aquino-Martinez, Sandra Harding, Joseph Lawrence Harpt, Yuetiva Deming, Sterling Johnson, Sanjay Asthana, Henrik Zetterberg, Kaj Blennow, Corinne D Engelman, Tyler K Ulland, Fredrik Bäckhed, Barbara B Bendlin, Federico E Rey
Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology
Infectious diseases (London, England)
Published

Increased immune activation in people living with HIV on antiretroviral therapy but not when compared with persons on HIV preexposure prophylaxis

Authors
Josefina Robertson, Arvid Edén, Aylin Yilmaz, Lars-Magnus Andersson, Lars Hagberg, Kristina Nyström, Staffan Nilsson, Carl-Johan Treutiger, Petra Tunbäck, Johanna M Gostner, Henrik Zetterberg, Magnus Gisslén
Increased immune activation in people living with HIV on antiretroviral therapy but not when compared with persons on HIV preexposure prophylaxis
Alzheimer's & dementia (Amsterdam, Netherlands)
Published

Online46: Online cognitive assessments in elderly cohorts-The British 1946 birth cohort case study

Authors
Ziyuan Cai, Valentina Giunchiglia, Rebecca Street, Martina Del Giovane, Kirsty Lu, Maria Popham, Andrew Wong, Heidi Murray-Smith, Marcus Richards, Sebastian Crutch, Peter J Hellyer, Jonathan M Schott, Adam Hampshire
Online46: Online cognitive assessments in elderly cohorts-The British 1946 birth cohort case study