Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
The lancet. Psychiatry
Published

The trajectory of sedative adverse events caused by antipsychotics: a meta-analysis of individual participant data from randomised, placebo-controlled, clinical trials in acute phase schizophrenia

Authors
Nobuyuki Nomura, Spyridon Siafis, Johannes Schneider-Thoma, Lasse Brandt, Jinyoung Park, Orestis Efthimiou, Josef Priller, John M Davis, Hiroyoshi Takeuchi, Stefan Leucht
The trajectory of sedative adverse events caused by antipsychotics: a meta-analysis of individual participant data from randomised, placebo-controlled, clinical trials in acute phase schizophrenia
Brain, behavior, and immunity
Published

The schizophrenia-associated gene CSMD1 encodes a complement classical pathway inhibitor predominantly expressed by astrocytes and at synapses in mice and humans

Authors
Robert A J Byrne, Jacqui Nimmo, Megan Torvell, Sarah M Carpanini, Nikoleta Daskoulidou, Timothy R Hughes, Lucy V Noble, Aurora Veteleanu, Lewis M Watkins, Wioleta M Zelek, Michael C O'Donovan, B Paul Morgan
The schizophrenia-associated gene CSMD1 encodes a complement classical pathway inhibitor predominantly expressed by astrocytes and at synapses in mice and humans
Movement disorders : official journal of the Movement Disorder Society
Published

Long-Term Stability of Spatial Distribution and Peak Dynamics of Subthalamic Beta Power in Parkinson's Disease Patients

Authors
Jennifer K Behnke, Robert L Peach, Jeroen G V Habets, Johannes L Busch, Jonathan Kaplan, Jan Roediger, Varvara Mathiopoulou, Lucia K Feldmann, Moritz Gerster, Juliette Vivien, Gerd-Helge Schneider, Katharina Faust, Patricia Krause, Andrea A Kühn
Long-Term Stability of Spatial Distribution and Peak Dynamics of Subthalamic Beta Power in Parkinson's Disease Patients
Acta neuropathologica
Published

Biofluid-based staging of Alzheimer's disease

Authors
Juan Lantero-Rodriguez, Laia Montoliu-Gaya, Nicholas J Ashton, Ilaria Pola, Joseph Therriault, Nesrine Rahmouni, Wagner S Brum, Stijn Servaes, Jenna Stevenson, Guglielmo Di Molfetta, Burak Arslan, Jesse Klostranec, Paolo Vitali, Maxime Montembeault, Serge Gauthier, Cecile Tissot, Arthur C Macedo, Tharick A Pascoal, Andreas Jeromin, Johan Gobom, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea L Benedet
Biofluid-based staging of Alzheimer's disease
medRxiv : the preprint server for health sciences
Published

Older more fit KL-VS heterozygotes have more favorable AD-relevant biomarker profiles

Authors
Mackenzie Jarchow, Ira Driscoll, Brianne M Breidenbach, Noah Cook, Catherine L Gallagher, Sterling C Johnson, Sanjay Asthana, Bruce P Hermann, Mark A Sager, Kaj Blennow, Henrik Zetterberg, Cynthia M Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Dane B Cook, Dena B Dubal, Ozioma C Okonkwo
Older more fit KL-VS heterozygotes have more favorable AD-relevant biomarker profiles
medRxiv : the preprint server for health sciences
Published

The impact of cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline

Authors
A J Paulsen, I Driscoll, B M Breidenbach, M P Glittenberg, S R Lose, Y Ma, M A Sager, C M Carlsson, C L Gallagher, B P Hermann, K Blennow, H Zetterberg, S Asthana, S C Johnson, T J Betthauser, B T Christian, D B Cook, O C Okonkwo
The impact of cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline
Nature communications
Published

Axonal RNA localization is essential for long-term memory

Authors
Bruna R de Queiroz, Hiba Laghrissi, Seetha Rajeev, Lauren Blot, Fabienne De Graeve, Marine Dehecq, Martina Hallegger, Ugur Dag, Marion Dunoyer de Segonzac, Mirana Ramialison, Chantal Cazevieille, Krystyna Keleman, Jernej Ule, Arnaud Hubstenberger, Florence Besse
Axonal RNA localization is essential for long-term memory
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Published

How does autophagy impact neurological function?

Authors
Angeleen Fleming, Ana Lopez, Matea Rob, Sarayu Ramakrishna, So Jung Park, Xinyi Li, David C Rubinsztein
How does autophagy impact neurological function?
bioRxiv : the preprint server for biology
Published

Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease

Authors
Clíona Farrell, Yazead Buhidma, Paige Mumford, Wendy E Heywood, Jenny Hällqvist, Lisi Flores-Aguilar, Elizabeth Andrews, Negin Rahimzadah, Orjona Stella Taso, Eric Doran, Vivek Swarup, Elizabeth Head, Tammaryn Lashley, Kevin Mills, Christina E Toomey, Frances K Wiseman
Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease
Annals of clinical and translational neurology
Published

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

Authors
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M Brody, Ann Brinkmalm, Simon Sjödin, Adama J Berndt, Marc Carceles-Cordon, EunRan Suh, Vivianna M Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B Lee, Henrik Zetterberg, Alice S Chen-Plotkin
Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes
Nature neuroscience
Published

Author Correction: Neuronal polyunsaturated fatty acids are protective in ALS/FTD

Authors
Ashling Giblin, Alexander J Cammack, Niek Blomberg, Sharifah Anoar, Alla Mikheenko, Mireia Carcolé, Magda L Atilano, Alex Hull, Dunxin Shen, Xiaoya Wei, Rachel Coneys, Lele Zhou, Yassene Mohammed, Damien Olivier-Jimenez, Lian Y Wang, Kerri J Kinghorn, Teresa Niccoli, Alyssa N Coyne, Rik van der Kant, Tammaryn Lashley, Martin Giera, Linda Partridge, Adrian M Isaacs
Author Correction: Neuronal polyunsaturated fatty acids are protective in ALS/FTD