Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Cell Rep
Published

Cholesterol determines the cytosolic entry and seeded aggregation of tau.

Authors
Benjamin J Tuck, Lauren V C Miller, Taxiarchis Katsinelos, Annabel E Smith, Emma L Wilson, Sophie Keeling, Shi Cheng, Marina J Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C James, William A McEwan
Cholesterol determines the cytosolic entry and seeded aggregation of tau.
Exp Neurol
Published

DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.

Authors
Mayela Zamora, Robert Toth, Francesca Morgante, Jon Ottaway, Tom Gillbe, Sean Martin, Guy Lamb, Tara Noone, Moaad Benjaber, Zachary Nairac, Devang Sehgal, Timothy G Constandinou, Jeffrey Herron, Tipu Z Aziz, Ivor Gillbe, Alexander L Green, Erlick A C Pereira, Timothy Denison
DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.
Biosens Bioelectron
Published

Multiplexed immunosensors for point-of-care diagnostic applications.

Authors
Bruno Gil Rosa, Oluwatomi E Akingbade, Xiaotong Guo, Laura Gonzalez-Macia, Michael A Crone, Loren P Cameron, Paul Freemont, Kwang-Leong Choy, Firat Güder, Eric Yeatman, David J Sharp, Bing Li
Multiplexed immunosensors for point-of-care diagnostic applications.
Biosens Bioelectron
Published

Multiplexed immunosensors for point-of-care diagnostic applications.

Authors
Bruno Gil Rosa, Oluwatomi E Akingbade, Xiaotong Guo, Laura Gonzalez-Macia, Michael A Crone, Loren P Cameron, Paul Freemont, Kwang-Leong Choy, Firat Güder, Eric Yeatman, David J Sharp, Bing Li
Multiplexed immunosensors for point-of-care diagnostic applications.
Nature
Published

Somatic mosaicism reveals clonal distributions of neocortical development.

Authors
Martin W Breuss, Xiaoxu Yang, Johannes C M Schlachetzki, Danny Antaki, Addison J Lana, Xin Xu, Changuk Chung, Guoliang Chai, Valentina Stanley, Qiong Song, Traci F Newmeyer, An Nguyen, Sydney O'Brien, Marten A Hoeksema, Beibei Cao, Alexi Nott, Jennifer McEvoy-Venneri, Martina P Pasillas, Scott T Barton, Brett R Copeland, Shareef Nahas, Lucitia Van Der Kraan, Yan Ding, Christopher K Glass, Joseph G Gleeson
Somatic mosaicism reveals clonal distributions of neocortical development.
Nature
Published

Somatic mosaicism reveals clonal distributions of neocortical development.

Authors
Martin W Breuss, Xiaoxu Yang, Johannes C M Schlachetzki, Danny Antaki, Addison J Lana, Xin Xu, Changuk Chung, Guoliang Chai, Valentina Stanley, Qiong Song, Traci F Newmeyer, An Nguyen, Sydney O'Brien, Marten A Hoeksema, Beibei Cao, Alexi Nott, Jennifer McEvoy-Venneri, Martina P Pasillas, Scott T Barton, Brett R Copeland, Shareef Nahas, Lucitia Van Der Kraan, Yan Ding, , Christopher K Glass, Joseph G Gleeson
Somatic mosaicism reveals clonal distributions of neocortical development.
J Neurosci
Published

Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.

Authors
Paula de Oliveira, Claire Cella, Nicolas Locker, Kiran K G Ravindran, Agampodi Mendis, Keith Wafford, Gary Gilmour, Derk-Jan Dijk, Raphaelle Winsky-Sommerer
Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.
J Neurosci
Published

Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.

Authors
Paula de Oliveira, Claire Cella, Nicolas Locker, Kiran K G Ravindran, Agampodi Mendis, Keith Wafford, Gary Gilmour, Derk-Jan Dijk, Raphaelle Winsky-Sommerer
Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.
Acta Neuropathol
Published

Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.

Authors
Laura de Boni, Aurelia Hays Watson, Ludovica Zaccagnini, Amber Wallis, Kristina Zhelcheska, Nora Kim, John Sanderson, Haiyang Jiang, Elodie Martin, Adam Cantlon, Matteo Rovere, Lei Liu, Marc Sylvester, Tammaryn Lashley, Ulf Dettmer, Zane Jaunmuktane, Tim Bartels
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.
Acta Neuropathol
Published

Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.

Authors
Laura de Boni, Aurelia Hays Watson, Ludovica Zaccagnini, Amber Wallis, Kristina Zhelcheska, Nora Kim, John Sanderson, Haiyang Jiang, Elodie Martin, Adam Cantlon, Matteo Rovere, Lei Liu, Marc Sylvester, Tammaryn Lashley, Ulf Dettmer, Zane Jaunmuktane, Tim Bartels
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.
Nat Neurosci
Published

Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset.

Authors
Branduff McAllister, Jasmine Donaldson, Caroline S Binda, Sophie Powell, Uroosa Chughtai, Gareth Edwards, Joseph Stone, Sergey Lobanov, Linda Elliston, Laura-Nadine Schuhmacher, Elliott Rees, Georgina Menzies, Marc Ciosi, Alastair Maxwell, Michael J Chao, Eun Pyo Hong, Diane Lucente, Vanessa Wheeler, Jong-Min Lee, Marcy E MacDonald, Jeffrey D Long, Elizabeth H Aylward, G Bernhard Landwehrmeyer, Anne E Rosser, Jane S Paulsen, Nigel M Williams, James F Gusella, Darren G Monckton, Nicholas D Allen, Peter Holmans, Lesley Jones, Thomas H Massey
Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset.