Publications

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Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Lancet Digit Health

Published Jun 29, 2023

Comprehensive genomic profiling and treatment patterns across ancestries in advanced prostate cancer: a large-scale retrospective analysis.

Authors

Smruthy Sivakumar, Jessica K Lee, Jay A Moore, Julia Hopkins, Justin Y Newberg, Russell Madison, Ryon Graf, Alexa B Schrock, Erin Kobetz, Randy Vince, Idalid Franco, Crystal Seldon, Garrett M Frampton, Jennifer Mills, Jeffrey Venstrom, Brandon A Mahal

Comprehensive genomic profiling and treatment patterns across ancestries in advanced prostate cancer: a large-scale retrospective analysis.

Nat Commun

Published Jun 08, 2023

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

Authors

Irene Molina-Gonzalez, Rebecca K Holloway, Zoeb Jiwaji, Owen Dando, Sarah A Kent, Katie Emelianova, Amy F Lloyd, Lindsey H Forbes, Ayisha Mahmood, Thomas Skripuletz, Viktoria Gudi, James A Febery, Jeffrey A Johnson, Jill H Fowler, Tanja Kuhlmann, Anna Williams, Siddharthan Chandran, Martin Stangel, Andrew J M Howden, Giles E Hardingham, Veronique E Miron

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

Nat Commun

Published Jun 08, 2023

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

Authors

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

Glia

Published Jun 06, 2023

Complement receptor 1 is expressed on brain cells and in the human brain.

Authors

Nikoleta Daskoulidou, Bethany Shaw, Megan Torvell, Lewis Watkins, Emma L Cope, Sarah M Carpanini, Nicholas D Allen, B Paul Morgan

Complement receptor 1 is expressed on brain cells and in the human brain.

bioRxiv

Published Jun 05, 2023

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function.

Authors

K R Bowles, D A Pugh, C Pedicone, L Oja, S A Weitzman, Y Liu, J L Chen, M D Disney, A M Goate

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function.

Toxicon

Published Jun 01, 2023

Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons.

Authors

Chiara Panzi, Sunaina Surana, Samantha De La-Rocque, Edoardo Moretto, Oscar Marcelo Lazo, Giampietro Schiavo

Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons.

Toxicon

Published Jun 01, 2023

Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons.

Authors

Chiara Panzi, Sunaina Surana, Samantha De La-Rocque, Edoardo Moretto, Oscar Marcelo Lazo, Giampietro Schiavo

Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons.

Front Hum Neurosci

Published May 24, 2023

Hyper-parameter tuning and feature extraction for asynchronous action detection from sub-thalamic nucleus local field potentials.

Authors

Thomas Martineau, Shenghong He, Ravi Vaidyanathan, Huiling Tan

Hyper-parameter tuning and feature extraction for asynchronous action detection from sub-thalamic nucleus local field potentials.

Int J Mol Sci

Published May 17, 2023

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

Authors

Yoel Hirsch, Wendy K Chung, Sergey Novoselov, Louis H Weimer, Alexander Rossor, Charles A LeDuc, Amanda J McPartland, Ernesto Cabrera, Josef Ekstein, Sholem Scher, Rick F Nelson, Giampietro Schiavo, Lindsay B Henderson, Kevin T A Booth

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

Int J Mol Sci

Published May 17, 2023

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

Authors

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

J Cereb Blood Flow Metab

Published May 14, 2023

Blood-CNS barrier dysfunction in amyotrophic lateral sclerosis: Proposed mechanisms and clinical implications.

Authors

Moritz Steinruecke, Rebecca Murphy Lonergan, Bhuvaneish T Selvaraj, Siddharthan Chandran, Blanca Diaz-Castro, Maria Stavrou

Blood-CNS barrier dysfunction in amyotrophic lateral sclerosis: Proposed mechanisms and clinical implications.

JMIR Res Protoc

Published May 11, 2023

Assessing a Sleep Interviewing Chatbot to Improve Subjective and Objective Sleep: Protocol for an Observational Feasibility Study.

Authors

Ting Su, Rafael A Calvo, Melanie Jouaiti, Sarah Daniels, Pippa Kirby, Derk-Jan Dijk, Ciro Della Monica, Ravi Vaidyanathan

Assessing a Sleep Interviewing Chatbot to Improve Subjective and Objective Sleep: Protocol for an Observational Feasibility Study.

JMIR Res Protoc

Published May 11, 2023

Assessing a Sleep Interviewing Chatbot to Improve Subjective and Objective Sleep: Protocol for an Observational Feasibility Study.

Authors

Ting Su, Rafael A Calvo, Melanie Jouaiti, Sarah Daniels, Pippa Kirby, Derk-Jan Dijk, Ciro Della Monica, Ravi Vaidyanathan

Assessing a Sleep Interviewing Chatbot to Improve Subjective and Objective Sleep: Protocol for an Observational Feasibility Study.

JCI Insight

Published May 08, 2023

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

Authors

James N Sleigh, David Villarroel-Campos, Sunaina Surana, Tahmina Wickenden, Yao Tong, Rebecca L Simkin, Jose Norberto S Vargas, Elena R Rhymes, Andrew P Tosolini, Steven J West, Qian Zhang, Xiang-Lei Yang, Giampietro Schiavo

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

JCI Insight

Published May 08, 2023

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

Authors

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

PLoS One

Published May 01, 2023

What does heritability of Alzheimer's disease represent?

Authors

Emily Baker, Ganna Leonenko, Karl Michael Schmidt, Matthew Hill, Amanda J Myers, Maryam Shoai, Itziar de Rojas, Niccoló Tesi, Henne Holstege, Wiesje M van der Flier, Yolande A L Pijnenburg, Agustin Ruiz, John Hardy, Sven van der Lee, Valentina Escott-Price

What does heritability of Alzheimer's disease represent?

Int J Mol Sci

Published May 01, 2023

Single-Cell Transcriptomics Reveals Conserved Regulatory Networks in Human and Mouse Interneuron Development.

Authors

Francesca Keefe, Jimena Monzón-Sandoval, Anne E Rosser, Caleb Webber, Meng Li

Single-Cell Transcriptomics Reveals Conserved Regulatory Networks in Human and Mouse Interneuron Development.

Semin Cell Dev Biol

Published Apr 30, 2023

Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease.

Authors

Leire Melgosa-Ecenarro, Nazanin Doostdar, Carola I Radulescu, Johanna S Jackson, Samuel J Barnes

Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease.