Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

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- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Cell reports
Published

Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes

Authors
Kathryn R Bowles, Chiara Pedicone, Derian A Pugh, Laura-Maria Oja, Filipa H Sousa, Lois K Keavey, Brian Fulton-Howard, Sarah A Weitzman, Yiyuan Liu, Jonathan L Chen, Matthew D Disney, Alison M Goate
Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes
British journal of cancer
Published

Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study

Authors
Wing Ching Chan, Lili Liu, Emmanouil Bouras, Verena Zuber, Wanqing Wen, Jirong Long, Dipender Gill, Neil Murphy, Marc J Gunter, Themistocles L Assimes, Luis Bujanda, Stephen B Gruber, Sébastien Küry, Brigid M Lynch, Conghui Qu, Minta Thomas, Emily White, Michael O Woods, Ulrike Peters, Christopher I Li, Andrew T Chan, Hermann Brenner, Konstantinos K Tsilidis, Wei Zheng
Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study
Alzheimer's research & therapy
Published

Elevated plasma p-tau231 is associated with reduced generalization and medial temporal lobe dynamic network flexibility among healthy older African Americans

Authors
Miray Budak, Bernadette A Fausto, Zuzanna Osiecka, Mustafa Sheikh, Robert Perna, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, Patricia Fitzgerald-Bocarsly, Mark A Gluck
Elevated plasma p-tau231 is associated with reduced generalization and medial temporal lobe dynamic network flexibility among healthy older African Americans
bioRxiv : the preprint server for biology
Published

Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates

Authors
Anna E Fürtjes, Isabelle F Foote, Charley Xia, Gail Davies, Joanna Moodie, Adele Taylor, David C Liewald, Paul Redmond, Janie Corley, Andrew M McIntosh, Heather C Whalley, Susana Muñoz Maniega, Maria Valdés Hernández, Ellen Backhouse, Karen Ferguson, Mark E Bastin, Joanna Wardlaw, Javier de la Fuente, Andrew D Grotzinger, Michelle Luciano, W David Hill, Ian J Deary, Elliot M Tucker-Drob, Simon R Cox
Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates
bioRxiv : the preprint server for biology
Published

Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: an improved mouse model of Alzheimer's disease without mutations in <em>MAPT</em>

Authors
Sneha Desai, Elena Camporesi, Gunnar Brinkmalm, Argyro Alatza, Jack I Wood, Takshashila Tripathi, Sumi Bez, Nazar Stasyuk, Haady B Hajar, Takashi Saito, Takaomi C Saido, John Hardy, Damian M Cummings, Jörg Hanrieder, Frances A Edwards
Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: an improved mouse model of Alzheimer's disease without mutations in <em>MAPT</em>
Journal of the neurological sciences
Published

Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders

Authors
Dhamidhu Eratne, Matthew J Y Kang, Courtney Lewis, Christa Dang, Charles Malpas, Suyi Ooi, Amy Brodtmann, David Darby, Henrik Zetterberg, Kaj Blennow, Michael Berk, Olivia Dean, Chad Bousman, Naveen Thomas, Ian Everall, Chris Pantelis, Cassandra Wannan, Claudia Cicognola, Oskar Hansson, Shorena Janelidze, Alexander F Santillo, Dennis Velakoulis, MiND Study Group
Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders
medRxiv : the preprint server for health sciences
Published

Plasma p-tau212 as a biomarker of sporadic and Down Syndrome Alzheimer's disease

Authors
Przemysław R Kac, Daniel Alcolea, Laia Montoliu-Gaya, Susana Fernández, Juan Lantero Rodriguez, Lucía Maure, Fernando González-Ortiz, Bessy Benejam, Michael Turton, Isabel Barroeta, Peter Harrison, Laura Videla, Nicholas J Ashton, Alberto Lleó, Henrik Zetterberg, María Carmona-Iragui, Thomas K Karikari, Juan Fortea, Kaj Blennow
Plasma p-tau212 as a biomarker of sporadic and Down Syndrome Alzheimer's disease
The Lancet. Neurology
Published

Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study

Authors
Yihua Ma, Carly M Farris, Sandrina Weber, Sebastian Schade, Hieu Nguyen, Alexandra Pérez-Soriano, Darly M Giraldo, Manel Fernández, Marta Soto, Ana Cámara, Celia Painous, Esteban Muñoz, Francesc Valldeoriola, Maria J Martí, Jordi Clarimon, Pekka Kallunki, Thong Chi Ma, Roy N Alcalay, Bárbara Fernandez Gomes, Kaj Blennow, Henrik Zetterberg, Julius Constantinescu, David Mengel, Vaibhavi Kadam, Piero Parchi, Kathrin Brockmann, Thomas F Tropea, Andrew Siderowf, Matthis Synofzik, Un Jung Kang, Yaroslau Compta, Per Svenningsson, Brit Mollenhauer, Luis Concha-Marambio
Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study
Nature neuroscience
Published

Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease

Authors
Stephanie L Fowler, Tiana S Behr, Emir Turkes, Darragh P O'Brien, Paula Maglio Cauhy, Isadora Rawlinson, Marisa Edmonds, Martha S Foiani, Ari Schaler, Gerard Crowley, Sumi Bez, Elena Ficulle, Eliona Tsefou, Roman Fischer, Beth Geary, Pallavi Gaur, Chelsea Miller, Pasquale D'Acunzo, Efrat Levy, Karen E Duff, Benjamin Ryskeldi-Falcon
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases

Authors
William Z Lin, Di Yu, Lisa Y Xiong, Julia Zebarth, Ruoding Wang, Corinne E Fischer, Tarek K Rajji, David F Tang-Wai, Carmela Tartaglia, Gustavo Saposnik, Richard H Swartz, David A Grimes, Anthony E Lang, Robert A Hegele, Sali Farhan, Joel Ramirez, Sean Symons, Maged Goubran, Malcolm A Binns, Wendy Lou, Roger A Dixon, Joseph B Orange, Angela C Roberts, Angela K Troyer, Henrik Zetterberg, Nathan Herrmann, Jennifer S Rabin, Bradley J MacIntosh, Mario Masellis, Krista L Lanctôt, Sandra E Black, Walter Swardfager, ONDRI Investigators
Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease

Authors
Ramiro Eduardo Rea Reyes, Karly A Cody, Rachael E Wilson, Henrik Zetterberg, Nathaniel A Chin, Erin M Jonaitis, Melissa Bahr, Olivia Mandel, Madilynn Wintlend, Barbara B Bendlin, Ozioma C Okonkwo, Lindsay R Clark, Matt Zammit, Sanjay Asthana, Bradley T Christian, Tobey J Betthauser, Laura Eisenmenger, Rebecca E Langhough, Sterling C Johnson
Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease
Annals of neurology
Published

Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease

Authors
Michael S Stringer, Gordon W Blair, Anna Kopczak, Danielle Kerkhofs, Michael J Thrippleton, Francesca M Chappell, Susana Muñoz Maniega, Rosalind Brown, Kirsten Shuler, Iona Hamilton, Daniela Jaime Garcia, Fergus N Doubal, Una Clancy, Eleni Sakka, Tetiana Poliakova, Esther Janssen, Marco Duering, Michael Ingrisch, Julie Staals, Walter H Backes, Robert van Oostenbrugge, Geert Jan Biessels, Martin Dichgans, Joanna M Wardlaw, SVDs@target consortium
Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Published

Associations of life-course cardiovascular risk factors with late-life cerebral haemodynamics

Authors
Mathijs Bj Dijsselhof, Jorina Holtrop, Sarah-Naomi James, Carole H Sudre, Kirsty Lu, Luigi Lorenzini, Lyduine E Collij, Catherine J Scott, Emily N Manning, David L Thomas, Marcus Richards, Alun D Hughes, David M Cash, Frederik Barkhof, Jonathan M Schott, Jan Petr, Henk Jmm Mutsaerts
Associations of life-course cardiovascular risk factors with late-life cerebral haemodynamics