Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
Nat Neurosci
Published

Stem-cell-derived human microglia transplanted in mouse brain to study human disease.

Authors
Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Oliver Burton, Adrian Liston, Annerieke Sierksma, Yannick Fourne, Suresh Poovathingal, Amaia Arranz-Mendiguren, Carlo Sala Frigerio, Christel Claes, Lutgarde Serneels, Tom Theys, V Hugh Perry, Catherine Verfaillie, Mark Fiers, Bart De Strooper
Stem-cell-derived human microglia transplanted in mouse brain to study human disease.
Mol Psychiatry
Published

Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.

Authors
Navneet A Vasistha, Mandy Johnstone, Samantha K Barton, Steffen E Mayerl, Bhuvaneish Thangaraj Selvaraj, Pippa A Thomson, Owen Dando, Ellen Grünewald, Clara Alloza, Mark E Bastin, Matthew R Livesey, Kyriakos Economides, Dario Magnani, Paraskevi Makedonopolou, Karen Burr, David J Story, Douglas H R Blackwood, David J A Wyllie, Andrew M McIntosh, J Kirsty Millar, Charles Ffrench-Constant, Giles E Hardingham, Stephen M Lawrie, Siddharthan Chandran
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.
Science
Published

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.

Authors
Ross Nortley, Nils Korte, Pablo Izquierdo, Chanawee Hirunpattarasilp, Anusha Mishra, Zane Jaunmuktane, Vasiliki Kyrargyri, Thomas Pfeiffer, Lila Khennouf, Christian Madry, Hui Gong, Angela Richard-Loendt, Wenhui Huang, Takashi Saito, Takaomi C Saido, Sebastian Brandner, Huma Sethi, David Attwell
Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.
Nat Protoc
Published

Derivation and maintenance of mouse haploid embryonic stem cells.

Authors
Ulrich Elling, Michael Woods, Josep V Forment, Beiyuan Fu, Fengtang Yang, Bee Ling Ng, Jose R Vicente, David J Adams, Brendan Doe, Stephen P Jackson, Josef M Penninger, Gabriel Balmus
Derivation and maintenance of mouse haploid embryonic stem cells.
PLoS Pathog
Published

The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.

Authors
Aiysha Thompson, Luke C Davies, Chia-Te Liao, Diogo M da Fonseca, James S Griffiths, Robert Andrews, Adam V Jones, Mathew Clement, Gordon D Brown, Ian R Humphreys, Philip R Taylor, Selinda J Orr
The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.
Nat Rev Neurol
Published

SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases.

Authors
Ross W Paterson, Audrey Gabelle, Brendan P Lucey, Nicolas R Barthélemy, Claire A Leckey, Christophe Hirtz, Sylvain Lehmann, Chihiro Sato, Bruce W Patterson, Tim West, Kevin Yarasheski, Jonathan D Rohrer, Norelle C Wildburger, Jonathan M Schott, Celeste M Karch, Selina Wray, Timothy M Miller, Donald L Elbert, Henrik Zetterberg, Nick C Fox, Randall J Bateman
SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases.
N Engl J Med
Published

Targeting Huntingtin Expression in Patients with Huntington's Disease.

Authors
Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards, Anne Rosser, Holly B Kordasiewicz, Christian Czech, Eric E Swayze, Daniel A Norris, Tiffany Baumann, Irene Gerlach, Scott A Schobel, Erika Paz, Anne V Smith, C Frank Bennett, Roger M Lane,
Targeting Huntingtin Expression in Patients with Huntington's Disease.
Nat Neurosci
Published

Central nervous system regeneration is driven by microglia necroptosis and repopulation.

Authors
Amy F Lloyd, Claire L Davies, Rebecca K Holloway, Yasmine Labrak, Graeme Ireland, Dario Carradori, Alessandra Dillenburg, Eva Borger, Daniel Soong, Jill C Richardson, Tanja Kuhlmann, Anna Williams, Jeffrey W Pollard, Anne des Rieux, Josef Priller, Veronique E Miron
Central nervous system regeneration is driven by microglia necroptosis and repopulation.