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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Journal of the American Heart Association
Published

Choroid Plexus Volume in Rural Chinese Older Adults: Distribution and Association With Cardiovascular Risk Factors and Cerebral Small Vessel Disease

Authors
Chunyan Li, Huisi Zhang, Jiafeng Wang, Xiaodong Han, Cuicui Liu, Yuanjing Li, Tao Gong, Tingting Hou, Yongxiang Wang, Lin Cong, Grégoria Kalpouzos, Joanna Wardlaw, Lin Song, Yifeng Du, Chengxuan Qiu
Choroid Plexus Volume in Rural Chinese Older Adults: Distribution and Association With Cardiovascular Risk Factors and Cerebral Small Vessel Disease
medRxiv : the preprint server for health sciences
Published

Genome-wide scan of Flortaucipir PET levels finds <em>JARID2</em> associated with cerebral tau deposition

Authors
Tamil Iniyan Gunasekaran, Devendra Meena, Annie J Lee, Siwei Wu, Logan Dumitrescu, Reisa Sperling, Timothy J Hohman, Alzheimer’s Disease Neuroimaging Initiative, A4 Study, Jingxian Huang, Abbas Dehghan, Ioanna Tzoulaki, Richard Mayeux, Badri Vardarajan
Genome-wide scan of Flortaucipir PET levels finds <em>JARID2</em> associated with cerebral tau deposition
bioRxiv : the preprint server for biology
Published

Isotope Encoded chemical Imaging Identifies Amyloid Plaque Age Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity

Authors
Jack I Wood, Maciej Dulewicz, Junyue Ge, Katie Stringer, Alicja Szadziewska, Sneha Desai, Srinivas Koutarapu, Haady B Hajar, Kaj Blennow, Henrik Zetterberg, Damian M Cummings, Jeffrey N Savas, Frances A Edwards, Jörg Hanrieder
Isotope Encoded chemical Imaging Identifies Amyloid Plaque Age Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity
Neuron
Published

Autophagy, aging, and age-related neurodegeneration

Authors
Jennifer E Palmer, Niall Wilson, Sung Min Son, Pawel Obrocki, Lidia Wrobel, Matea Rob, Michael Takla, Viktor I Korolchuk, David C Rubinsztein
Autophagy, aging, and age-related neurodegeneration
JAMA network open
Published

Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds

Authors
Simon Fandler-Höfler, Sebastian Eppinger, Gareth Ambler, Philip Nash, Markus Kneihsl, Keon-Joo Lee, Jae-Sung Lim, Masayuki Shiozawa, Masatoshi Koga, Linxin Li, Caroline Lovelock, Hugues Chabriat, Michael Hennerici, Yuen Kwun Wong, Henry Ka Fung Mak, Luis Prats-Sanchez, Alejandro Martínez-Domeño, Shigeru Inamura, Kazuhisa Yoshifuji, Ethem Murat Arsava, Solveig Horstmann, Jan Purrucker, Bonnie Yin Ka Lam, Adrian Wong, Young Dae Kim, Tae-Jin Song, Robin Lemmens, Ender Uysal, Zeynep Tanriverdi, Natan M Bornstein, Einor Ben Assayag, Hen Hallevi, Jeremy Molad, Masashi Nishihara, Jun Tanaka, Shelagh B Coutts, Alexandros Polymeris, Benjamin Wagner, David J Seiffge, Philippe Lyrer, L Jaap Kappelle, Rustam Al-Shahi Salman, Maria Valdes Hernandez, Hans R Jäger, Gregory Y H Lip, Urs Fischer, Marwan El-Koussy, Jean-Louis Mas, Laurence Legrand, Christopher Karayiannis, Thanh Phan, Sarah Gunkel, Nicolas Christ, Jill Abrigo, Winnie Chu, Thomas Leung, Francesca Chappell, Stephen Makin, Derek Hayden, David J Williams, Werner H Mess, M Eline Kooi, Carmen Barbato, Simone Browning, Anil M Tuladhar, Noortje Maaijwee, Anne Cristine Guevarra, Anne-Marie Mendyk, Christine Delmaire, Sebastian Köhler, Robert van Oostenbrugge, Ying Zhou, Chao Xu, Saima Hilal, Caroline Robert, Christopher Chen, Min Lou, Julie Staals, Régis Bordet, Nagaendran Kandiah, Frank-Erik de Leeuw, Robert Simister, Daniel Bos, Peter J Kelly, Joanna Wardlaw, Yannie Soo, Felix Fluri, Velandai Srikanth, David Calvet, Simon Jung, Vincent I H Kwa, Stefan T Engelter, Nils Peters, Eric E Smith, Hideo Hara, Yusuke Yakushiji, Dilek Necioglu Orken, Vincent Thijs, Ji Hoe Heo, Vincent Mok, Roland Veltkamp, Hakan Ay, Toshio Imaizumi, Kui Kai Lau, Eric Jouvent, Peter M Rothwell, Kazunori Toyoda, Hee-Joon Bae, Joan Marti-Fabregas, Duncan Wilson, Jonathan Best, Franz Fazekas, Christian Enzinger, David J Werring, Thomas Gattringer, Microbleeds International Collaborative Network
Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds
Clinical chemistry and laboratory medicine
Published

The correlation of albumin with total protein concentrations in cerebrospinal fluid across three automated analysers - relevance to the diagnosis of subarachnoid haemorrhage in clinical chemistry practice

Authors
Marcus Clarin, Elin Gustafsson, Carina Gustafsson, Maria Lohmander, Henrik Zetterberg
The correlation of albumin with total protein concentrations in cerebrospinal fluid across three automated analysers - relevance to the diagnosis of subarachnoid haemorrhage in clinical chemistry practice
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Head-to-head comparison of leading blood tests for Alzheimer's disease pathology

Authors
Suzanne E Schindler, Kellen K Petersen, Benjamin Saef, Duygu Tosun, Leslie M Shaw, Henrik Zetterberg, Jeffrey L Dage, Kyle Ferber, Gallen Triana-Baltzer, Lei Du-Cuny, Yan Li, Janaky Coomaraswamy, Michael Baratta, Yulia Mordashova, Ziad S Saad, David L Raunig, Nicholas J Ashton, Emily A Meyers, Carrie E Rubel, Erin G Rosenbaugh, Anthony W Bannon, William Z Potter, Alzheimer's Disease Neuroimaging Initiative (ADNI) Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer's Disease Project Team
Head-to-head comparison of leading blood tests for Alzheimer's disease pathology
Journal of neurology, neurosurgery, and psychiatry
Published

Poor long-term outcomes and abnormal neurodegeneration biomarkers after military traumatic brain injury: the ADVANCE study

Authors
Neil Sn Graham, Grace Blissitt, Karl Zimmerman, Lydia Orton, Daniel Friedland, Emma Coady, Rhiannon Laban, Elena Veleva, Amanda J Heslegrave, Henrik Zetterberg, Susie Schofield, Nicola T Fear, Christopher J Boos, Anthony M J Bull, Alexander Bennett, David J Sharp, ADVANCE Study
Poor long-term outcomes and abnormal neurodegeneration biomarkers after military traumatic brain injury: the ADVANCE study
European journal of neurology
Published

Pre-hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the RIGHT-2 trial

Authors
Jason P Appleton, Mark Dixon, Lisa J Woodhouse, Craig S Anderson, Sandeep Ankolekar, Lesley Cala, Timothy J England, Peter J Godolphin, Kailash Krishnan, Grant Mair, Keith W Muir, John Potter, Chris I Price, Marc Randall, Thompson G Robinson, Christine Roffe, Peter M Rothwell, Else Charlotte Sandset, Jeffrey L Saver, A Niroshan Siriwardena, Joanna M Wardlaw, Nikola Sprigg, Philip M Bath, RIGHT‐2 Investigators
Pre-hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the RIGHT-2 trial
Molecular psychiatry
Published

Sex/gender effects of glial reactivity on preclinical Alzheimer's disease pathology

Authors
Clara Vila-Castelar, Muge Akinci, Eleni Palpatzis, Pablo Aguilar-Dominguez, Gregory Operto, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Kaj Blennow, Henrik Zetterberg, Carles Falcon, Karine Fauria, Juan Domingo Gispert, Oriol Grau-Rivera, Marc Suárez-Calvet, Eider M Arenaza-Urquijo, ALFA study
Sex/gender effects of glial reactivity on preclinical Alzheimer's disease pathology
Aging Cell
Published

Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons.

Authors
James N Sleigh, Francesca Mattedi, Sandy Richter, Emily Annuario, Kristal Ng, I Emilie Steinmark, Iveta Ivanova, István L Darabán, Parth P Joshi, Elena R Rhymes, Shirwa Awale, Gokhan Yahioglu, Jacqueline C Mitchell, Klaus Suhling, Giampietro Schiavo, Alessio Vagnoni
Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons.
medRxiv : the preprint server for health sciences
Published

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

Authors
Luis M García-Marín, Adrian I Campos, Santiago Diaz-Torres, Jill A Rabinowitz, Zuriel Ceja, Brittany L Mitchell, Katrina L Grasby, Jackson G Thorp, Ingrid Agartz, Saud Alhusaini, David Ames, Philippe Amouyel, Ole A Andreassen, Konstantinos Arfanakis, Alejandro Arias Vasquez, Nicola J Armstrong, Lavinia Athanasiu, Mark E Bastin, Alexa S Beiser, David A Bennett, Joshua C Bis, Marco Pm Boks, Dorret I Boomsma, Henry Brodaty, Rachel M Brouwer, Jan K Buitelaar, Ralph Burkhardt, Wiepke Cahn, Vince D Calhoun, Owen T Carmichael, Mallar Chakravarty, Qiang Chen, Christopher R K Ching, Sven Cichon, Benedicto Crespo-Facorro, Fabrice Crivello, Anders M Dale, George Davey Smith, Eco Jc de Geus, Philip L De Jager, Greig I de Zubicaray, Stéphanie Debette, Charles DeCarli, Chantal Depondt, Sylvane Desrivières, Srdjan Djurovic, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Guillén Fernández, Irina Filippi, Simon E Fisher, Debra A Fleischman, Evan Fletcher, Myriam Fornage, Andreas J Forstner, Clyde Francks, Barbara Franke, Tian Ge, Aaron L Goldman, Hans J Grabe, Robert C Green, Oliver Grimm, Nynke A Groenewold, Oliver Gruber, Vilmundur Gudnason, Asta K Håberg, Unn K Haukvik, Andreas Heinz, Derrek P Hibar, Saima Hilal, Jayandra J Himali, Beng-Choon Ho, David F Hoehn, Pieter J Hoekstra, Edith Hofer, Wolfgang Hoffmann, Avram J Holmes, Georg Homuth, Norbert Hosten, M Kamran Ikram, Jonathan C Ipser, Clifford R Jack, Neda Jahanshad, Erik G Jönsson, Rene S Kahn, Ryota Kanai, Marieke Klein, Maria J Knol, Lenore J Launer, Stephen M Lawrie, Stephanie Le Hellard, Phil H Lee, Hervé Lemaître, Shuo Li, David Cm Liewald, Honghuang Lin, W T Longstreth, Oscar L Lopez, Michelle Luciano, Pauline Maillard, Andre F Marquand, Nicholas G Martin, Jean-Luc Martinot, Karen A Mather, Venkata S Mattay, Katie L McMahon, Patrizia Mecocci, Ingrid Melle, Andreas Meyer-Lindenberg, Nazanin Mirza-Schreiber, Yuri Milaneschi, Thomas H Mosley, Thomas W Mühleisen, Bertram Müller-Myhsok, Susana Muñoz Maniega, Matthias Nauck, Kwangsik Nho, Wiro J Niessen, Markus M Nöthen, Paul A Nyquist, Jaap Oosterlaan, Massimo Pandolfo, Tomas Paus, Zdenka Pausova, Brenda Wjh Penninx, G Bruce Pike, Bruce M Psaty, Benno Pütz, Simone Reppermund, Marcella D Rietschel, Shannon L Risacher, Nina Romanczuk-Seiferth, Rafael Romero-Garcia, Gennady V Roshchupkin, Jerome I Rotter, Perminder S Sachdev, Philipp G Sämann, Arvin Saremi, Muralidharan Sargurupremraj, Andrew J Saykin, Lianne Schmaal, Helena Schmidt, Reinhold Schmidt, Peter R Schofield, Markus Scholz, Gunter Schumann, Emanuel Schwarz, Li Shen, Jean Shin, Sanjay M Sisodiya, Albert V Smith, Jordan W Smoller, Hilkka S Soininen, Vidar M Steen, Dan J Stein, Jason L Stein, Sophia I Thomopoulos, Arthur W Toga, Diana Tordesillas-Gutiérrez, Julian N Trollor, Maria C Valdes-Hernandez, Dennis van 't Ent, Hans van Bokhoven, Dennis van der Meer, Nic Ja van der Wee, Javier Vázquez-Bourgon, Dick J Veltman, Meike W Vernooij, Arno Villringer, Louis N Vinke, Henry Völzke, Henrik Walter, Joanna M Wardlaw, Daniel R Weinberger, Michael W Weiner, Wei Wen, Lars T Westlye, Eric Westman, Tonya White, A Veronica Witte, Christiane Wolf, Jingyun Yang, Marcel P Zwiers, M Arfan Ikram, Sudha Seshadri, Paul M Thompson, Claudia L Satizabal, Sarah E Medland, Miguel E Rentería
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
medRxiv : the preprint server for health sciences
Published

Gut-Brain Nexus: Mapping Multi-Modal Links to Neurodegeneration at Biobank Scale

Authors
Mohammad Shafieinouri, Samantha Hong, Artur Schuh, Mary B Makarious, Rodrigo Sandon, Paul Suhwan Lee, Emily Simmonds, Hirotaka Iwaki, Gracelyn Hill, Cornelis Blauwendraat, Valentina Escott-Price, Yue A Qi, Alastair J Noyce, Armando Reyes-Palomares, Hampton L Leonard, Malu Tansey, Anant Dadu, Faraz Faghri, Andrew Singleton, Mike A Nalls, Kristin S Levine, Sara Bandres-Ciga
Gut-Brain Nexus: Mapping Multi-Modal Links to Neurodegeneration at Biobank Scale
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma and CSF neurofilament light chain distinguish neurodegenerative from primary psychiatric conditions in a clinical setting

Authors
Dhamidhu Eratne, Matthew J Y Kang, Courtney Lewis, Christa Dang, Charles B Malpas, Michael Keem, Jasleen Grewal, Vladimir Marinov, Amy Coe, Cath Kaylor-Hughes, Thomas Borchard, Chhoa Keng-Hong, Alexandra Waxmann, Burcu Saglam, Tomas Kalincik, Richard Kanaan, Wendy Kelso, Andrew Evans, Sarah Farrand, Samantha Loi, Mark Walterfang, Christiane Stehmann, Qiao-Xin Li, Steven Collins, Colin L Masters, Alexander F Santillo, Henrik Zetterberg, Kaj Blennow, Samuel F Berkovic, Dennis Velakoulis, MiND Study Group
Plasma and CSF neurofilament light chain distinguish neurodegenerative from primary psychiatric conditions in a clinical setting