Publications

Featured

Jul 03, 2025 - Research

Dementia is rare in midlife rugby players, but long-term risk may be increased

A study of 200 former professional rugby players (aged 30-61 years old), researchers from the UK DRI, Imperial College London and University College London (affiliated...

Learn more Dementia is rare in midlife rugby players, but long-term risk may be increased

Jun 13, 2025 - Research

Essential Alzheimer’s-linked proteins found to sustain healthy brain activity

Researchers led by Dr Samuel Harris and Dr Marc Aurel Busche (UK DRI at UCL) have discovered that the amyloid precursor protein (APP) family, known...

Learn more Essential Alzheimer’s-linked proteins found to sustain healthy brain activity

May 29, 2025 - Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life

JAMA

Published Aug 08, 2023

Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.

Authors

John R Sims, Jennifer A Zimmer, Cynthia D Evans, Ming Lu, Paul Ardayfio, JonDavid Sparks, Alette M Wessels, Sergey Shcherbinin, Hong Wang, Emel Serap Monkul Nery, Emily C Collins, Paul Solomon, Stephen Salloway, Liana G Apostolova, Oskar Hansson, Craig Ritchie, Dawn A Brooks, Mark Mintun, Daniel M Skovronsky,

Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.

BMJ Open

Published Aug 03, 2023

Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol.

Authors

Mark Crook-Rumsey, Sarah J C Daniels, Subati Abulikemu, Helen Lai, Adrien Rapeaux, Charalambos Hadjipanayi, Eyal Soreq, Lucia M Li, James Bashford, Julian Jeyasingh-Jacob, Dragos C Gruia, Damion Lambert, Rimona Weil, Adam Hampshire, David J Sharp, Shlomi Haar

Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol.

Brain

Published Aug 01, 2023

Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

Authors

Maura Malpetti, Thomas E Cope, Duncan Street, P Simon Jones, Frank H Hezemans, Elijah Mak, Kamen A Tsvetanov, Timothy Rittman, W Richard Bevan-Jones, Karalyn Patterson, Luca Passamonti, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, John T O'Brien, James B Rowe

Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

J Huntingtons Dis

Published Jul 28, 2023

Understanding Sleep Regulation in Normal and Pathological Conditions, and Why It Matters.

Authors

Mathieu Nollet, Nicholas P Franks, William Wisden

Understanding Sleep Regulation in Normal and Pathological Conditions, and Why It Matters.

Cell Rep

Published Jul 25, 2023

Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.

Authors

Eleni Dimou, Taxiarchis Katsinelos, Georg Meisl, Benjamin J Tuck, Sophie Keeling, Annabel E Smith, Eric Hidari, Jeff Y L Lam, Melanie Burke, Sofia Lövestam, Rohan T Ranasinghe, William A McEwan, David Klenerman

Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.

Cell Rep

Published Jul 25, 2023

Simultaneous representation of multiple time horizons by entorhinal grid cells and CA1 place cells.

Authors

Prannoy Chaudhuri-Vayalambrone, Michael Everett Rule, Marius Bauza, Marino Krstulovic, Pauline Kerekes, Stephen Burton, Timothy O'Leary, Julija Krupic

Simultaneous representation of multiple time horizons by entorhinal grid cells and CA1 place cells.

Cell Rep Methods

Published Jul 24, 2023

A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.

Authors

Hinze Ho, Nejc Kejzar, Hiroki Sasaguri, Takashi Saito, Takaomi C Saido, Bart De Strooper, Marius Bauza, Julija Krupic

A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.

J Neuroinflammation

Published Jul 21, 2023

Alzheimer's disease-associated complement gene variants influence plasma complement protein levels.

Authors

Aurora Veteleanu, Joshua Stevenson-Hoare, Samuel Keat, Nikoleta Daskoulidou, Henrik Zetterberg, Amanda Heslegrave, Valentina Escott-Price, Julie Williams, Rebecca Sims, Wioleta M Zelek, Sarah M Carpanini, Bryan Paul Morgan

Alzheimer's disease-associated complement gene variants influence plasma complement protein levels.

iScience

Published Jul 21, 2023

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons.

Authors

Dayne A Beccano-Kelly, Marta Cherubini, Yassine Mousba, Kaitlyn M L Cramb, Stefania Giussani, Maria Claudia Caiazza, Pavandeep Rai, Siv Vingill, Nora Bengoa-Vergniory, Bryan Ng, Gabriele Corda, Abhirup Banerjee, Jane Vowles, Sally Cowley, Richard Wade-Martins

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons.

EMBO J

Published Jul 17, 2023

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

Authors

Julie Qiaojin Lin, Deepak Khuperkar, Sofia Pavlou, Stanislaw Makarchuk, Nikolaos Patikas, Flora Cy Lee, Julia M Zbiegly, Jianning Kang, Sarah F Field, David Md Bailey, Joshua L Freeman, Jernej Ule, Emmanouil Metzakopian, Marc-David Ruepp, Giovanna R Mallucci

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

Annu Int Conf IEEE Eng Med Biol Soc

Published Jul 16, 2023

Hearables: Automatic Sleep Scoring from Single-Channel Ear-EEG in Older Adults.

Authors

Ghena Hammour, Giuseppe Atzori, Ciro Della Monica, Kiran K G Ravindran, Victoria Revell, Derk-Jan Dijk, Danilo P Mandic

Hearables: Automatic Sleep Scoring from Single-Channel Ear-EEG in Older Adults.

Nat Rev Immunol

Published Jul 14, 2023

Microglia regulation of central nervous system myelin health and regeneration.

Authors

Sarah A Kent, Veronique E Miron

Microglia regulation of central nervous system myelin health and regeneration.

bioRxiv

Published Jul 11, 2023

Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations.

Authors

Taylor Bertucci, Kathryn R Bowles, Steven Lotz, Le Qi, Katherine Stevens, Susan K Goderie, Susan Borden, Laura Maria Oja, Keith Lane, Ryan Lotz, Hailey Lotz, Rebecca Chowdhury, Shona Joy, Brigitte L Arduini, David C Butler, Michael Miller, Heide Baron, Carl Alexander Sandhof, M Catarina Silva, Stephen J Haggarty, Celeste M Karch, Daniel H Geschwind, Alison M Goate, Sally Temple

Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations.

Annu Rev Neurosci

Published Jul 10, 2023

Astrocyte Endfeet in Brain Function and Pathology: Open Questions.

Authors

Blanca Díaz-Castro, Stefanie Robel, Anusha Mishra

Astrocyte Endfeet in Brain Function and Pathology: Open Questions.

Ann Hum Genet

Published Jul 07, 2023

Pitfalls of predicting age-related traits by polygenic risk scores.

Authors

Valentina Escott-Price, Karl Michael Schmidt

Pitfalls of predicting age-related traits by polygenic risk scores.

Neuron

Published Jul 05, 2023

Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration.

Authors

Beatrice Paola Festa, Farah H Siddiqi, Maria Jimenez-Sanchez, Hyeran Won, Matea Rob, Alvin Djajadikerta, Eleanna Stamatakou, David C Rubinsztein

Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration.

Wellcome Open Res

Published Jul 04, 2023

nf-core/clipseq - a robust Nextflow pipeline for comprehensive CLIP data analysis.

Authors

Charlotte West, Charlotte Capitanchik, Chris Cheshire, Nicholas M Luscombe, Anob Chakrabarti, Jernej Ule

nf-core/clipseq - a robust Nextflow pipeline for comprehensive CLIP data analysis.

Nat Med

Published Jul 03, 2023

Wearable movement-tracking data identify Parkinson's disease years before clinical diagnosis.

Authors

Ann-Kathrin Schalkamp, Kathryn J Peall, Neil A Harrison, Cynthia Sandor

Wearable movement-tracking data identify Parkinson's disease years before clinical diagnosis.