Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

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- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
J Neurosci
Published

Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21.

Authors
Paige Mumford, Justin Tosh, Silvia Anderle, Eleni Gkanatsiou Wikberg, Gloria Lau, Sue Noy, Karen Cleverley, Takashi Saito, Takaomi C Saido, Eugene Yu, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Henrik Zetterberg, Victor Tybulewicz, Elizabeth M C Fisher, Frances K Wiseman
Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21.
Sci Transl Med
Published

Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease.

Authors
Ashwin V Venkataraman, Ayla Mansur, Gaia Rizzo, Courtney Bishop, Yvonne Lewis, Ece Kocagoncu, Anne Lingford-Hughes, Mickael Huiban, Jan Passchier, James B Rowe, Hideo Tsukada, David J Brooks, Laurent Martarello, Robert A Comley, Laigao Chen, Adam J Schwarz, Richard Hargreaves, Roger N Gunn, Eugenii A Rabiner, Paul M Matthews
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease.
Lancet Neurol
Published

A biological classification of Huntington's disease: the Integrated Staging System.

Authors
Sarah J Tabrizi, Scott Schobel, Emily C Gantman, Alexandra Mansbach, Beth Borowsky, Pavlina Konstantinova, Tiago A Mestre, Jennifer Panagoulias, Christopher A Ross, Maurice Zauderer, Ariana P Mullin, Klaus Romero, Sudhir Sivakumaran, Emily C Turner, Jeffrey D Long, Cristina Sampaio,
A biological classification of Huntington's disease: the Integrated Staging System.
Mol Neurodegener
Published

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes.

Authors
Kathryn R Bowles, Derian A Pugh, Yiyuan Liu, Tulsi Patel, Alan E Renton, Sara Bandres-Ciga, Ziv Gan-Or, Peter Heutink, Ari Siitonen, Sarah Bertelsen, Jonathan D Cherry, Celeste M Karch, Steven J Frucht, Brian H Kopell, Inga Peter, Y J Park, , Alexander Charney, Towfique Raj, John F Crary, A M Goate
17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes.
Nat Neurosci
Published

Identification of early neurodegenerative pathways in progressive multiple sclerosis.

Authors
Max Kaufmann, Anna-Lena Schaupp, Rosa Sun, Fabian Coscia, Calliope A Dendrou, Adrian Cortes, Gurman Kaur, Hayley G Evans, Annelie Mollbrink, José Fernández Navarro, Jana K Sonner, Christina Mayer, Gabriele C DeLuca, Joakim Lundeberg, Paul M Matthews, Kathrine E Attfield, Manuel A Friese, Matthias Mann, Lars Fugger
Identification of early neurodegenerative pathways in progressive multiple sclerosis.
Science
Published

A specific circuit in the midbrain detects stress and induces restorative sleep.

Authors
Xiao Yu, Guangchao Zhao, Dan Wang, Sa Wang, Rui Li, Ao Li, Huan Wang, Mathieu Nollet, You Young Chun, Tianyuan Zhao, Raquel Yustos, Huiming Li, Jianshuai Zhao, Jiannan Li, Min Cai, Alexei L Vyssotski, Yulong Li, Hailong Dong, Nicholas P Franks, William Wisden
A specific circuit in the midbrain detects stress and induces restorative sleep.
Front Comput Neurosci
Published

Recent Trends in Non-invasive Neural Recording Based Brain-to-Brain Synchrony Analysis on Multidisciplinary Human Interactions for Understanding Brain Dynamics: A Systematic Review.

Authors
Tahnia Nazneen, Iffath Binta Islam, Md Sakibur Rahman Sajal, Wasifa Jamal, M Ashraful Amin, Ravi Vaidyanathan, Tom Chau, Khondaker A Mamun
Recent Trends in Non-invasive Neural Recording Based Brain-to-Brain Synchrony Analysis on Multidisciplinary Human Interactions for Understanding Brain Dynamics: A Systematic Review.