Publications

Featured

Jul 03, 2025 - Research

Dementia is rare in midlife rugby players, but long-term risk may be increased

A study of 200 former professional rugby players (aged 30-61 years old), researchers from the UK DRI, Imperial College London and University College London (affiliated...

Learn more Dementia is rare in midlife rugby players, but long-term risk may be increased

Jun 13, 2025 - Research

Essential Alzheimer’s-linked proteins found to sustain healthy brain activity

Researchers led by Dr Samuel Harris and Dr Marc Aurel Busche (UK DRI at UCL) have discovered that the amyloid precursor protein (APP) family, known...

Learn more Essential Alzheimer’s-linked proteins found to sustain healthy brain activity

May 29, 2025 - Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life

Brain

Published Jul 03, 2023

Functional genomics provide key insights to improve the diagnostic yield of hereditary ataxia.

Authors

Zhongbo Chen, Arianna Tucci, Valentina Cipriani, Emil K Gustavsson, Kristina Ibañez, Regina H Reynolds, David Zhang, Letizia Vestito, Alejandro Cisterna García, Siddharth Sethi, Jonathan W Brenton, Sonia García-Ruiz, Aine Fairbrother-Browne, Ana-Luisa Gil-Martinez, , Nick Wood, John A Hardy, Damian Smedley, Henry Houlden, Juan Botía, Mina Ryten

Functional genomics provide key insights to improve the diagnostic yield of hereditary ataxia.

JAMA Neurol

Published Jul 01, 2023

Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial.

Authors

Joanna M Wardlaw, Lisa J Woodhouse, Iris I Mhlanga, Katherine Oatey, Anna K Heye, John Bamford, Vera Cvoro, Fergus N Doubal, Timothy England, Ahamad Hassan, Alan Montgomery, John T O'Brien, Christine Roffe, Nikola Sprigg, David J Werring, Philip M Bath,

Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial.

Neuroimage

Published Jul 01, 2023

Higher order diffusion imaging as a putative index of human sleep-related microstructural changes and glymphatic clearance.

Authors

Balázs Örzsik, Marco Palombo, Iris Asllani, Derk-Jan Dijk, Neil A Harrison, Mara Cercignani

Higher order diffusion imaging as a putative index of human sleep-related microstructural changes and glymphatic clearance.

Nat Commun

Published Jun 08, 2023

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

Authors

Irene Molina-Gonzalez, Rebecca K Holloway, Zoeb Jiwaji, Owen Dando, Sarah A Kent, Katie Emelianova, Amy F Lloyd, Lindsey H Forbes, Ayisha Mahmood, Thomas Skripuletz, Viktoria Gudi, James A Febery, Jeffrey A Johnson, Jill H Fowler, Tanja Kuhlmann, Anna Williams, Siddharthan Chandran, Martin Stangel, Andrew J M Howden, Giles E Hardingham, Veronique E Miron

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

bioRxiv

Published Jun 05, 2023

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function.

Authors

K R Bowles, D A Pugh, C Pedicone, L Oja, S A Weitzman, Y Liu, J L Chen, M D Disney, A M Goate

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function.

Toxicon

Published Jun 01, 2023

Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons.

Authors

Chiara Panzi, Sunaina Surana, Samantha De La-Rocque, Edoardo Moretto, Oscar Marcelo Lazo, Giampietro Schiavo

Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons.

Front Hum Neurosci

Published May 24, 2023

Hyper-parameter tuning and feature extraction for asynchronous action detection from sub-thalamic nucleus local field potentials.

Authors

Thomas Martineau, Shenghong He, Ravi Vaidyanathan, Huiling Tan

Hyper-parameter tuning and feature extraction for asynchronous action detection from sub-thalamic nucleus local field potentials.

Int J Mol Sci

Published May 17, 2023

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

Authors

Yoel Hirsch, Wendy K Chung, Sergey Novoselov, Louis H Weimer, Alexander Rossor, Charles A LeDuc, Amanda J McPartland, Ernesto Cabrera, Josef Ekstein, Sholem Scher, Rick F Nelson, Giampietro Schiavo, Lindsay B Henderson, Kevin T A Booth

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

JMIR Res Protoc

Published May 11, 2023

Assessing a Sleep Interviewing Chatbot to Improve Subjective and Objective Sleep: Protocol for an Observational Feasibility Study.

Authors

Ting Su, Rafael A Calvo, Melanie Jouaiti, Sarah Daniels, Pippa Kirby, Derk-Jan Dijk, Ciro Della Monica, Ravi Vaidyanathan

Assessing a Sleep Interviewing Chatbot to Improve Subjective and Objective Sleep: Protocol for an Observational Feasibility Study.

JCI Insight

Published May 08, 2023

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

Authors

James N Sleigh, David Villarroel-Campos, Sunaina Surana, Tahmina Wickenden, Yao Tong, Rebecca L Simkin, Jose Norberto S Vargas, Elena R Rhymes, Andrew P Tosolini, Steven J West, Qian Zhang, Xiang-Lei Yang, Giampietro Schiavo

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

Semin Cell Dev Biol

Published Apr 30, 2023

Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease.

Authors

Leire Melgosa-Ecenarro, Nazanin Doostdar, Carola I Radulescu, Johanna S Jackson, Samuel J Barnes

Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease.

PLoS One

Published Apr 28, 2023

What does heritability of Alzheimer's disease represent?

Authors

Emily Baker, Ganna Leonenko, Karl Michael Schmidt, Matthew Hill, Amanda J Myers, Maryam Shoai, Itziar de Rojas, Niccoló Tesi, Henne Holstege, Wiesje M van der Flier, Yolande A L Pijnenburg, Agustin Ruiz, John Hardy, Sven van der Lee, Valentina Escott-Price

What does heritability of Alzheimer's disease represent?

Sci Rep

Published Apr 28, 2023

Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain.

Authors

William Lim Kee Chang, Tiffany G Chan, Federica Raguseo, Aishwarya Mishra, Dani Chattenton, Rafael T M de Rosales, Nicholas J Long, Sophie V Morse

Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain.

PLoS One

Published Apr 28, 2023

Unsupervised, frequent and remote: A novel platform for personalised digital phenotyping of long-term memory in humans.

Authors

Marius Bauza, Marino Krstulovic, Julija Krupic

Unsupervised, frequent and remote: A novel platform for personalised digital phenotyping of long-term memory in humans.

Sci Adv

Published Apr 21, 2023

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.

Authors

Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.

Nature

Published Apr 12, 2023

Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms.

Authors

Joselyn S Soto, Yasaman Jami-Alahmadi, Jakelyn Chacon, Stefanie L Moye, Blanca Diaz-Castro, James A Wohlschlegel, Baljit S Khakh

Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms.

bioRxiv

Published Apr 06, 2023

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human.

Authors

Philip Hasel, Melissa L Cooper, Anne E Marchildon, Uriel A Rufen-Blanchette, Rachel D Kim, Thong C Ma, Un Jung Kang, Moses V Chao, Shane A Liddelow

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human.

Cell Metab

Published Apr 04, 2023

Molecular and metabolic heterogeneity of astrocytes and microglia.

Authors

Philip Hasel, William H Aisenberg, F Chris Bennett, Shane A Liddelow

Molecular and metabolic heterogeneity of astrocytes and microglia.