Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

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- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Cell Stem Cell
Published

Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.

Authors
Lucia S Capano, Chihiro Sato, Elena Ficulle, Anan Yu, Kanta Horie, Ji-Sun Kwon, Kyle F Burbach, Nicolas R Barthélemy, Susan G Fox, Celeste M Karch, Randall J Bateman, Henry Houlden, Richard I Morimoto, David M Holtzman, Karen E Duff, Andrew S Yoo
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.
Acta Neuropathol
Published

Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model.

Authors
Sophie Quick, Tessa V Procter, Jonathan Moss, Luise Seeker, Marc Walton, Angus Lawson, Serena Baker, Anna Beletski, Daniela Jaime Garcia, Mehreen Mohammad, William Mungall, Ami Onishi, Zuzanna Tobola, Michael Stringer, Maurits A Jansen, Antoine Vallatos, Ylenia Giarratano, Miguel O Bernabeu, Joanna M Wardlaw, Anna Williams
Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model.
Cell Rep
Published

Cholesterol determines the cytosolic entry and seeded aggregation of tau.

Authors
Benjamin J Tuck, Lauren V C Miller, Taxiarchis Katsinelos, Annabel E Smith, Emma L Wilson, Sophie Keeling, Shi Cheng, Marina J Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C James, William A McEwan
Cholesterol determines the cytosolic entry and seeded aggregation of tau.
Exp Neurol
Published

DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.

Authors
Mayela Zamora, Robert Toth, Francesca Morgante, Jon Ottaway, Tom Gillbe, Sean Martin, Guy Lamb, Tara Noone, Moaad Benjaber, Zachary Nairac, Devang Sehgal, Timothy G Constandinou, Jeffrey Herron, Tipu Z Aziz, Ivor Gillbe, Alexander L Green, Erlick A C Pereira, Timothy Denison
DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.
Biosens Bioelectron
Published

Multiplexed immunosensors for point-of-care diagnostic applications.

Authors
Bruno Gil Rosa, Oluwatomi E Akingbade, Xiaotong Guo, Laura Gonzalez-Macia, Michael A Crone, Loren P Cameron, Paul Freemont, Kwang-Leong Choy, Firat Güder, Eric Yeatman, David J Sharp, Bing Li
Multiplexed immunosensors for point-of-care diagnostic applications.
Nature
Published

Somatic mosaicism reveals clonal distributions of neocortical development.

Authors
Martin W Breuss, Xiaoxu Yang, Johannes C M Schlachetzki, Danny Antaki, Addison J Lana, Xin Xu, Changuk Chung, Guoliang Chai, Valentina Stanley, Qiong Song, Traci F Newmeyer, An Nguyen, Sydney O'Brien, Marten A Hoeksema, Beibei Cao, Alexi Nott, Jennifer McEvoy-Venneri, Martina P Pasillas, Scott T Barton, Brett R Copeland, Shareef Nahas, Lucitia Van Der Kraan, Yan Ding, , Christopher K Glass, Joseph G Gleeson
Somatic mosaicism reveals clonal distributions of neocortical development.
J Neurosci
Published

Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.

Authors
Paula de Oliveira, Claire Cella, Nicolas Locker, Kiran K G Ravindran, Agampodi Mendis, Keith Wafford, Gary Gilmour, Derk-Jan Dijk, Raphaelle Winsky-Sommerer
Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.
Acta Neuropathol
Published

Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.

Authors
Laura de Boni, Aurelia Hays Watson, Ludovica Zaccagnini, Amber Wallis, Kristina Zhelcheska, Nora Kim, John Sanderson, Haiyang Jiang, Elodie Martin, Adam Cantlon, Matteo Rovere, Lei Liu, Marc Sylvester, Tammaryn Lashley, Ulf Dettmer, Zane Jaunmuktane, Tim Bartels
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.
Nat Neurosci
Published

Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset.

Authors
Branduff McAllister, Jasmine Donaldson, Caroline S Binda, Sophie Powell, Uroosa Chughtai, Gareth Edwards, Joseph Stone, Sergey Lobanov, Linda Elliston, Laura-Nadine Schuhmacher, Elliott Rees, Georgina Menzies, Marc Ciosi, Alastair Maxwell, Michael J Chao, Eun Pyo Hong, Diane Lucente, Vanessa Wheeler, Jong-Min Lee, Marcy E MacDonald, Jeffrey D Long, Elizabeth H Aylward, G Bernhard Landwehrmeyer, Anne E Rosser, Jane S Paulsen, Nigel M Williams, James F Gusella, Darren G Monckton, Nicholas D Allen, Peter Holmans, Lesley Jones, Thomas H Massey
Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset.
J Neurol Neurosurg Psychiatry
Published

Development of a sensitive trial-ready poly(GP) CSF biomarker assay for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis.

Authors
Katherine M Wilson, Eszter Katona, Idoia Glaria, Mireia Carcolé, Imogen J Swift, Aitana Sogorb-Esteve, Carolin Heller, Arabella Bouzigues, Amanda J Heslegrave, Ashvini Keshavan, Kathryn Knowles, Saurabh Patil, Susovan Mohapatra, Yuanjing Liu, Jaya Goyal, Raquel Sanchez-Valle, Robert Jr Laforce, Matthis Synofzik, James B Rowe, Elizabeth Finger, Rik Vandenberghe, Christopher R Butler, Alexander Gerhard, John C Van Swieten, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Alexandre de Mendonça, Mario Masellis, M Carmela Tartaglia, Markus Otto, Caroline Graff, Simon Ducharme, Jonathan M Schott, Andrea Malaspina, Henrik Zetterberg, Ramakrishna Boyanapalli, Jonathan D Rohrer, Adrian M Isaacs,
Development of a sensitive trial-ready poly(GP) CSF biomarker assay for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis.