Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

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- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Brain Behav Immun
Published

Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder.

Authors
Laura J Westacott, Trevor Humby, Niels Haan, Sophie A Brain, Emma-Louise Bush, Margarita Toneva, Andreea-Ingrid Baloc, Anna L Moon, Jack Reddaway, Michael J Owen, Jeremy Hall, Timothy R Hughes, B Paul Morgan, William P Gray, Lawrence S Wilkinson
Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder.
J Struct Biol
Published

Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2.

Authors
Antonette Bennett, Joshua Hull, Nelly Jolinon, Julie Tordo, Katie Moss, Enswert Binns, Mario Mietzsch, Cathleen Hagemann, R Michael Linden, Andrea Serio, Paul Chipman, Duncan Sousa, Felix Broecker, Peter Seeberger, Els Henckaerts, Robert McKenna, Mavis Agbandje-McKenna
Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2.
Cell Rep
Published

FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease.

Authors
Robert Goold, Joseph Hamilton, Thomas Menneteau, Michael Flower, Emma L Bunting, Sarah G Aldous, Antonio Porro, José R Vicente, Nicholas D Allen, Hilary Wilkinson, Gillian P Bates, Alessandro A Sartori, Konstantinos Thalassinos, Gabriel Balmus, Sarah J Tabrizi
FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease.
Cell
Published

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.

Authors
Kathryn R Bowles, M Catarina Silva, Kristen Whitney, Taylor Bertucci, Joshua E Berlind, Jesse D Lai, Jacob C Garza, Nathan C Boles, Sidhartha Mahali, Kevin H Strang, Jacob A Marsh, Cynthia Chen, Derian A Pugh, Yiyuan Liu, Ronald E Gordon, Susan K Goderie, Rebecca Chowdhury, Steven Lotz, Keith Lane, John F Crary, Stephen J Haggarty, Celeste M Karch, Justin K Ichida, Alison M Goate, Sally Temple
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Brain Behav Immun
Published

Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice.

Authors
Laura J Westacott, Niels Haan, Claudia Evison, Omar Marei, Jeremy Hall, Timothy R Hughes, Malik Zaben, B Paul Morgan, Trevor Humby, Lawrence S Wilkinson, William P Gray
Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice.
Sci Adv
Published

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.

Authors
Nicol Birsa, Agnieszka M Ule, Maria Giovanna Garone, Brian Tsang, Francesca Mattedi, P Andrew Chong, Jack Humphrey, Seth Jarvis, Melis Pisiren, Oscar G Wilkins, Micheal L Nosella, Anny Devoy, Cristian Bodo, Rafaela Fernandez de la Fuente, Elizabeth M C Fisher, Alessandro Rosa, Gabriella Viero, Julie D Forman-Kay, Giampietro Schiavo, Pietro Fratta
FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.
J Neurol Neurosurg Psychiatry
Published

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

Authors
Maura Malpetti, Luca Passamonti, Peter Simon Jones, Duncan Street, Timothy Rittman, Timothy D Fryer, Young T Hong, Patricia Vàsquez Rodriguez, William Richard Bevan-Jones, Franklin I Aigbirhio, John Tiernan O'Brien, James Benedict Rowe
Neuroinflammation predicts disease progression in progressive supranuclear palsy.