Publications

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Jan 17, 2025 - Research

Brain changes in Huntington’s disease occur decades before diagnosis

Subtle changes in the brain happen approximately twenty years before a clinical motor diagnosis in people with Huntington’s disease, finds a new study led by...

Learn more Brain changes in Huntington’s disease occur decades before diagnosis

Jan 08, 2025 - Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s

Phospho-tau accumulation in MAPT knockout mice

Jan 08, 2025 - Research

Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

A new study led by Prof Karen Duff, Dr Naoto Watamura, and Dr Martha Foiani (UK DRI at UCL), with Prof Takaomi Saido (Riken Center...

Learn more Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

Lancet Neurol

Published Feb 01, 2018

Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer's disease: a cross-sectional study.

Authors

Philip S J Weston, Jennifer M Nicholas, Susie M D Henley, Yuying Liang, Kirsty Macpherson, Elizabeth Donnachie, Jonathan M Schott, Martin N Rossor, Sebastian J Crutch, Christopher R Butler, Adam Z Zeman, Nick C Fox

Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer's disease: a cross-sectional study.

Nature

Published Feb 01, 2018

The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation.

Authors

Ruth A Wood, Marius Bauza, Julija Krupic, Stephen Burton, Andrea Delekate, Dennis Chan, John O'Keefe

The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation.

Dis Model Mech

Published Jan 30, 2018

The central role of DNA damage and repair in CAG repeat diseases.

Authors

Thomas H Massey, Lesley Jones

The central role of DNA damage and repair in CAG repeat diseases.

Acta Neuropathol

Published Jan 29, 2018

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.

Authors

Thomas G Moens, Sarah Mizielinska, Teresa Niccoli, Jamie S Mitchell, Annora Thoeng, Charlotte E Ridler, Sebastian Grönke, Jacqueline Esser, Amanda Heslegrave, Henrik Zetterberg, Linda Partridge, Adrian M Isaacs

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.

Nat Commun

Published Jan 24, 2018

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.

Authors

Bhuvaneish T Selvaraj, Matthew R Livesey, Chen Zhao, Jenna M Gregory, Owain T James, Elaine M Cleary, Amit K Chouhan, Angus B Gane, Emma M Perkins, Owen Dando, Simon G Lillico, Youn-Bok Lee, Agnes L Nishimura, Urjana Poreci, Sai Thankamony, Meryll Pray, Navneet A Vasistha, Dario Magnani, Shyamanga Borooah, Karen Burr, David Story, Alexander McCampbell, Christopher E Shaw, Peter C Kind, Timothy J Aitman, C Bruce A Whitelaw, Ian Wilmut, Colin Smith, Gareth B Miles, Giles E Hardingham, David J A Wyllie, Siddharthan Chandran

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.

Neuron

Published Jan 17, 2018

Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1.

Authors

Christian Madry, Vasiliki Kyrargyri, I Lorena Arancibia-Cárcamo, Renaud Jolivet, Shinichi Kohsaka, Robert M Bryan, David Attwell

Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1.

Cell Rep

Published Jan 16, 2018

Size-Dependent Axonal Bouton Dynamics following Visual Deprivation In Vivo.

Authors

Rosanna P Sammons, Claudia Clopath, Samuel J Barnes

Size-Dependent Axonal Bouton Dynamics following Visual Deprivation In Vivo.

Schizophr Res

Published Dec 24, 2017

Complement system biomarkers in first episode psychosis.

Authors

Maja Kopczynska, Wioleta Zelek, Samuel Touchard, Fiona Gaughran, Marta Di Forti, Valeria Mondelli, Robin Murray, Michael C O'Donovan, B Paul Morgan

Complement system biomarkers in first episode psychosis.

Hum Mol Genet

Published Dec 15, 2017

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.

Authors

Youn-Bok Lee, Pranetha Baskaran, Jorge Gomez-Deza, Han-Jou Chen, Agnes L Nishimura, Bradley N Smith, Claire Troakes, Yoshitsugu Adachi, Alan Stepto, Leonard Petrucelli, Jean-Marc Gallo, Frank Hirth, Boris Rogelj, Sarah Guthrie, Christopher E Shaw

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.

Nat Rev Neurosci

Published Nov 23, 2017

Lineage divergence of activity-driven transcription and evolution of cognitive ability.

Authors

Giles E Hardingham, Priit Pruunsild, Michael E Greenberg, Hilmar Bading

Lineage divergence of activity-driven transcription and evolution of cognitive ability.

Neurology

Published Nov 21, 2017

Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration.

Authors

Philip S J Weston, Teresa Poole, Natalie S Ryan, Akshay Nair, Yuying Liang, Kirsty Macpherson, Ronald Druyeh, Ian B Malone, R Laila Ahsan, Hugh Pemberton, Jana Klimova, Simon Mead, Kaj Blennow, Martin N Rossor, Jonathan M Schott, Henrik Zetterberg, Nick C Fox

Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration.

PLoS One

Published Nov 16, 2017

Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension.

Authors

Hideaki Suzuki, He Gao, Wenjia Bai, Evangelos Evangelou, Ben Glocker, Declan P O'Regan, Paul Elliott, Paul M Matthews

Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension.

Neuron

Published Nov 15, 2017

Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss.

Authors

Samuel J Barnes, Eleonora Franzoni, R Irene Jacobsen, Ferenc Erdelyi, Gabor Szabo, Claudia Clopath, Georg B Keller, Tara Keck

Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss.

EMBO Mol Med

Published Nov 07, 2017

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

Authors

Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert-Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie-Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

Wellcome Open Res

Published Nov 02, 2017

Rare variants of the 3'-5' DNA exonuclease TREX1 in early onset small vessel stroke.

Authors

Sarah McGlasson, Kristiina Rannikmäe, Steven Bevan, Clare Logan, Louise S Bicknell, Alexa Jury, , Andrew P Jackson, Hugh S Markus, Cathie Sudlow, David P J Hunt

Rare variants of the 3'-5' DNA exonuclease TREX1 in early onset small vessel stroke.

J Neurosci

Published Sep 13, 2017

Individual Movement Variability Magnitudes Are Explained by Cortical Neural Variability.

Authors

Shlomi Haar, Opher Donchin, Ilan Dinstein

Individual Movement Variability Magnitudes Are Explained by Cortical Neural Variability.

Elife

Published Sep 12, 2017

A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia.

Authors

Nathan G Skene, Marcia Roy, Seth Gn Grant

A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia.

Nat Commun

Published Aug 18, 2017

Corrigendum: Adrenergic-mediated loss of splenic marginal zone B cells contributes to infection susceptibility after stroke.

Authors

Laura McCulloch, Craig J Smith, Barry W McColl

Corrigendum: Adrenergic-mediated loss of splenic marginal zone B cells contributes to infection susceptibility after stroke.