Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

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- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Brain Pathol
Published

The association between neurodegeneration and local complement activation in the thalamus to progressive multiple sclerosis outcome.

Authors
Benjamin J Cooze, Matthew Dickerson, Rukshikah Loganathan, Lewis M Watkins, Ethan Grounds, Ben R Pearson, Ryan Jack Bevan, B Paul Morgan, Roberta Magliozzi, Richard Reynolds, James W Neal, Owain W Howell
The association between neurodegeneration and local complement activation in the thalamus to progressive multiple sclerosis outcome.
Nat Commun
Published

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.

Authors
Zoeb Jiwaji, Sachin S Tiwari, Rolando X Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M Smith, Peta Greer, Matthew Ball, Peter C Kind, Paul M Matthews, Colin Smith, Owen Dando, Tara L Spires-Jones, Jeffrey A Johnson, Siddharthan Chandran, Giles E Hardingham
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.
Dev Cell
Published

iPSC-derived myelinoids to study myelin biology of humans.

Authors
Owen G James, Bhuvaneish T Selvaraj, Dario Magnani, Karen Burr, Peter Connick, Samantha K Barton, Navneet A Vasistha, David W Hampton, David Story, Robert Smigiel, Rafal Ploski, Peter J Brophy, Charles Ffrench-Constant, David A Lyons, Siddharthan Chandran
iPSC-derived myelinoids to study myelin biology of humans.
Nat Med
Published

Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection.

Authors
Martina Patone, Lahiru Handunnetthi, Defne Saatci, Jiafeng Pan, Srinivasa Vittal Katikireddi, Saif Razvi, David Hunt, Xue W Mei, Sharon Dixon, Francesco Zaccardi, Kamlesh Khunti, Peter Watkinson, Carol A C Coupland, James Doidge, David A Harrison, Rommel Ravanan, Aziz Sheikh, Chris Robertson, Julia Hippisley-Cox
Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection.
Brain
Published

Plasma amyloid-β ratios in autosomal dominant Alzheimer's disease: the influence of genotype.

Authors
Antoinette O'Connor, Josef Pannee, Teresa Poole, Charles Arber, Erik Portelius, Imogen J Swift, Amanda J Heslegrave, Emily Abel, Nanet Willumsen, Helen Rice, Philip S J Weston, Natalie S Ryan, James M Polke, Jennifer M Nicholas, Simon Mead, Selina Wray, Lucía Chávez-Gutiérrez, Chris Frost, Kaj Blennow, Henrik Zetterberg, Nick C Fox
Plasma amyloid-β ratios in autosomal dominant Alzheimer's disease: the influence of genotype.
Sci Adv
Published

In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.

Authors
Georg Meisl, Eric Hidari, Kieren Allinson, Timothy Rittman, Sarah L DeVos, Justin S Sanchez, Catherine K Xu, Karen E Duff, Keith A Johnson, James B Rowe, Bradley T Hyman, Tuomas P J Knowles, David Klenerman
In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.
Cell Stem Cell
Published

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.

Authors
Hannah Walgrave, Sriram Balusu, Sarah Snoeck, Elke Vanden Eynden, Katleen Craessaerts, Nicky Thrupp, Leen Wolfs, Katrien Horré, Yannick Fourne, Alicja Ronisz, Edina Silajdžić, Amber Penning, Giorgia Tosoni, Zsuzsanna Callaerts-Vegh, Rudi D'Hooge, Dietmar Rudolf Thal, Henrik Zetterberg, Sandrine Thuret, Mark Fiers, Carlo Sala Frigerio, Bart De Strooper, Evgenia Salta
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.