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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Cell reports
Published

Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation

Authors
Dunxin Shen, Alec Vincent, Evan Udine, Yazead Buhidma, Sharifah Anoar, Elli Tsintzas, Marie Maeland, Dongwei Xu, Mireia Carcolé, David Osumi-Sutherland, Benjamin Aleyakpo, Alexander Hull, Guillermo Martínez Corrales, Nathan Woodling, Rosa Rademakers, Adrian M Isaacs, Carlo Frigerio, Marka van Blitterswijk, Tammaryn Lashley, Teresa Niccoli
Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation
Nature communications
Published

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau

Authors
Diana Acosta Ingram, Emir Turkes, Tae Yeon Kim, Sheeny Vo, Nicholas Sweeney, Marie-Amandine Bonte, Ryan Rutherford, Dominic L Julian, Meixia Pan, Jacob Marsh, Andrea R Argouarch, Min Wu, Douglas W Scharre, Erica H Bell, Lawrence S Honig, Jean Paul Vonsattel, Geidy E Serrano, Thomas G Beach, Celeste M Karch, Aimee W Kao, Mark E Hester, Xianlin Han, Hongjun Fu
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
Nature medicine
Published

Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform

Authors
Sebastian Palmqvist, Noëlle Warmenhoven, Federica Anastasi, Andrea Pilotto, Shorena Janelidze, Pontus Tideman, Erik Stomrud, Niklas Mattsson-Carlgren, Ruben Smith, Rik Ossenkoppele, Kübra Tan, Anna Dittrich, Ingmar Skoog, Henrik Zetterberg, Virginia Quaresima, Chiara Tolassi, Kina Höglund, Duilio Brugnoni, Albert Puig-Pijoan, Aida Fernández-Lebrero, José Contador, Alessandro Padovani, Mark Monane, Philip B Verghese, Joel B Braunstein, Silke Kern, Kaj Blennow, Nicholas J Ashton, Marc Suárez-Calvet, Oskar Hansson
Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform
Acta neuropathologica
Published

Seeding-competent early tau multimers are associated with cell type-specific transcriptional signatures

Authors
Rahel Feleke, Simona Jogaudaite, Elisavet Velentza-Almpani, Leung Yeung-Yeung, Daniel Clode, Jeong Hun Ko, Ben Shin, Steve Matthews, Maria Otero-Jimenez, Marcelina J Wojewska, Sandra Gray-Rodriguez, Sarah J Marzi, Maxwell P Spires-Jones, Tara L Spires-Jones, Michael R Johnson, Javier Alegre-Abarrategui
Seeding-competent early tau multimers are associated with cell type-specific transcriptional signatures
Nature communications
Published

A blood- and brain-based EWAS of smoking

Authors
Aleksandra D Chybowska, Elena Bernabeu, Paul Yousefi, Matthew Suderman, Robert F Hillary, Richard Clark, Louise MacGillivray, Lee Murphy, Sarah E Harris, Janie Corley, Archie Campbell, Tara L Spires-Jones, Daniel L McCartney, Simon R Cox, Jackie F Price, Kathryn L Evans, Riccardo E Marioni
A blood- and brain-based EWAS of smoking
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Modified titration of donanemab reduces ARIA risk and maintains amyloid reduction

Authors
Hong Wang, Emel Serap Monkul Nery, Paul Ardayfio, Rashna Khanna, Diana Otero Svaldi, Ivelina Gueorguieva, Sergey Shcherbinin, Scott W Andersen, Paula M Hauck, Staci E Engle, Dawn A Brooks, Emily C Collins, Nick C Fox, Steven M Greenberg, Stephen Salloway, Mark A Mintun, John R Sims
Modified titration of donanemab reduces ARIA risk and maintains amyloid reduction
medRxiv : the preprint server for health sciences
Published

Identification of GGC Repeat Expansions in <em>ZFHX3</em> Among Chilean Movement Disorder Patients

Authors
Paula Saffie-Awad, Abraham Moller, Kensuke Daida, Pilar Alvarez Jerez, Zhongbo Chen, Zachary B Anderson, Mariam Isayan, Kimberly Paquette, Sophia B Gibson, Madison Fulcher, Abigail Miano-Burkhardt, Laksh Malik, Breeana Baker, Paige Jarreau, Henry Houlden, Mina Ryten, Bida Gu, Mark Jp Chaisson, Danny E Miller, Pedro Chaná-Cuevas, Cornelis Blauwendraat, Andrew B Singleton, Kimberley J Billingsley
Identification of GGC Repeat Expansions in <em>ZFHX3</em> Among Chilean Movement Disorder Patients
Neurology
Published

Grief and Economic Stressors by Sex, Gender, and Education: Associations With Alzheimer Disease-Related Outcomes

Authors
Eleni Palpatzis, Muge Akinci, Marina Garcia-Prat, Kaj Blennow, Henrik Zetterberg, Clara Quijano-Rubio, Gwendlyn Kollmorgen, Norbert Wild, Juan Domingo Gispert, Marc Suárez-Calvet, Oriol Grau-Rivera, Karine Fauria, Anna Brugulat-Serrat, Gonzalo Sanchez-Benavides, Eider M Arenaza-Urquijo, ALFA study
Grief and Economic Stressors by Sex, Gender, and Education: Associations With Alzheimer Disease-Related Outcomes
Nature medicine
Published

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease

Authors
Hamilton Se-Hwee Oh, Deniz Yagmur Urey, Linda Karlsson, Zeyu Zhu, Yuanyuan Shen, Amelia Farinas, Jigyasha Timsina, Michael R Duggan, Jingsha Chen, Ian H Guldner, Nader Morshed, Chengran Yang, Daniel Western, Muhammad Ali, Yann Le Guen, Alexandra Trelle, Sanna-Kaisa Herukka, Tuomas Rauramaa, Mikko Hiltunen, Anssi Lipponen, Antti J Luikku, Kathleen L Poston, Elizabeth Mormino, Anthony D Wagner, Edward N Wilson, Divya Channappa, Ville Leinonen, Beth Stevens, Alexander J Ehrenberg, Rebecca F Gottesman, Josef Coresh, Keenan A Walker, Henrik Zetterberg, David A Bennett, Nicolai Franzmeier, Oskar Hansson, Carlos Cruchaga, Tony Wyss-Coray
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease
Movement disorders : official journal of the Movement Disorder Society
Published

Plasma Biomarkers and Disease Prognosis in Mild Cognitive Impairment with Lewy Bodies

Authors
Paul C Donaghy, Jahfer Hasoon, Calum A Hamilton, Joanna Ciafone, Rory Durcan, Nicola Barnett, Kirsty Olsen, Sarah Lawley, Gemma Greenfinch, Michael Firbank, Amanda Heslegrave, Henrik Zetterberg, Louise Allan, John T O'Brien, John-Paul Taylor, Alan J Thomas
Plasma Biomarkers and Disease Prognosis in Mild Cognitive Impairment with Lewy Bodies
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Diagnostic accuracy of plasma p-tau217/Aβ42 for Alzheimer's disease in clinical and community cohorts

Authors
Jun Wang, Shan Huang, Guoyu Lan, Yu-Jie Lai, Qing-Hua Wang, Yang Chen, Zhong-Song Xiao, Xiao Chen, Xian-Le Bu, Yu-Hui Liu, Fan Zeng, Laihong Zhang, Anqi Li, Yue Cai, Pan Sun, Zhengbo He, Vincent Doré, Jurgen Fripp, Pierrick Bourgeat, Qin Chen, Jin-Tai Yu, Yi Tang, Henrik Zetterberg, Colin L Masters, Tengfei Guo, Yan-Jiang Wang, Translational Biomarker Research of AgIng and Neurodegeneration (TBRAIN)
Diagnostic accuracy of plasma p-tau217/Aβ42 for Alzheimer's disease in clinical and community cohorts