Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

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- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Nat Genet
Published

Genetic identification of brain cell types underlying schizophrenia.

Authors
Nathan G Skene, Julien Bryois, Trygve E Bakken, Gerome Breen, James J Crowley, Héléna A Gaspar, Paola Giusti-Rodriguez, Rebecca D Hodge, Jeremy A Miller, Ana B Muñoz-Manchado, Michael C O'Donovan, Michael J Owen, Antonio F Pardiñas, Jesper Ryge, James T R Walters, Sten Linnarsson, Ed S Lein, , Patrick F Sullivan, Jens Hjerling-Leffler
Genetic identification of brain cell types underlying schizophrenia.
Nat Commun
Published

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.

Authors
Gabriel Balmus, Delphine Larrieu, Ana C Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J Geisler, Christopher J Lelliott, Jacqueline K White, Natasha A Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, , David J Adams, Stephen P Jackson
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.
Acta Neuropathol
Published

Activin receptors regulate the oligodendrocyte lineage in health and disease.

Authors
Alessandra Dillenburg, Graeme Ireland, Rebecca K Holloway, Claire L Davies, Frances L Evans, Matthew Swire, Marie E Bechler, Daniel Soong, Tracy J Yuen, Gloria H Su, Julie-Clare Becher, Colin Smith, Anna Williams, Veronique E Miron
Activin receptors regulate the oligodendrocyte lineage in health and disease.
Nat Commun
Published

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.

Authors
Bhuvaneish T Selvaraj, Matthew R Livesey, Chen Zhao, Jenna M Gregory, Owain T James, Elaine M Cleary, Amit K Chouhan, Angus B Gane, Emma M Perkins, Owen Dando, Simon G Lillico, Youn-Bok Lee, Agnes L Nishimura, Urjana Poreci, Sai Thankamony, Meryll Pray, Navneet A Vasistha, Dario Magnani, Shyamanga Borooah, Karen Burr, David Story, Alexander McCampbell, Christopher E Shaw, Peter C Kind, Timothy J Aitman, C Bruce A Whitelaw, Ian Wilmut, Colin Smith, Gareth B Miles, Giles E Hardingham, David J A Wyllie, Siddharthan Chandran
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.
Schizophr Res
Published

Complement system biomarkers in first episode psychosis.

Authors
Maja Kopczynska, Wioleta Zelek, Samuel Touchard, Fiona Gaughran, Marta Di Forti, Valeria Mondelli, Robin Murray, Michael C O'Donovan, B Paul Morgan
Complement system biomarkers in first episode psychosis.
Hum Mol Genet
Published

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.

Authors
Youn-Bok Lee, Pranetha Baskaran, Jorge Gomez-Deza, Han-Jou Chen, Agnes L Nishimura, Bradley N Smith, Claire Troakes, Yoshitsugu Adachi, Alan Stepto, Leonard Petrucelli, Jean-Marc Gallo, Frank Hirth, Boris Rogelj, Sarah Guthrie, Christopher E Shaw
C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.
Neurology
Published

Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration.

Authors
Philip S J Weston, Teresa Poole, Natalie S Ryan, Akshay Nair, Yuying Liang, Kirsty Macpherson, Ronald Druyeh, Ian B Malone, R Laila Ahsan, Hugh Pemberton, Jana Klimova, Simon Mead, Kaj Blennow, Martin N Rossor, Jonathan M Schott, Henrik Zetterberg, Nick C Fox
Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration.