Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

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- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Mol Neurodegener
Published

Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction.

Authors
Emma M Perkins, Karen Burr, Poulomi Banerjee, Arpan R Mehta, Owen Dando, Bhuvaneish T Selvaraj, Daumante Suminaite, Jyoti Nanda, Christopher M Henstridge, Thomas H Gillingwater, Giles E Hardingham, David J A Wyllie, Siddharthan Chandran, Matthew R Livesey
Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction.
Lancet Neurol
Published

New insights into atypical Alzheimer's disease in the era of biomarkers.

Authors
Jonathan Graff-Radford, Keir X X Yong, Liana G Apostolova, Femke H Bouwman, Maria Carrillo, Bradford C Dickerson, Gil D Rabinovici, Jonathan M Schott, David T Jones, Melissa E Murray
New insights into atypical Alzheimer's disease in the era of biomarkers.
Brain
Published

Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70.

Authors
Ashvini Keshavan, Josef Pannee, Thomas K Karikari, Juan Lantero Rodriguez, Nicholas J Ashton, Jennifer M Nicholas, David M Cash, William Coath, Christopher A Lane, Thomas D Parker, Kirsty Lu, Sarah M Buchanan, Sarah E Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M Schott
Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70.
Nat Neurosci
Published

Reactive astrocyte nomenclature, definitions, and future directions.

Authors
Carole Escartin, Elena Galea, András Lakatos, James P O'Callaghan, Gabor C Petzold, Alberto Serrano-Pozo, Christian Steinhäuser, Andrea Volterra, Giorgio Carmignoto, Amit Agarwal, Nicola J Allen, Alfonso Araque, Luis Barbeito, Ari Barzilai, Dwight E Bergles, Gilles Bonvento, Arthur M Butt, Wei-Ting Chen, Martine Cohen-Salmon, Colm Cunningham, Benjamin Deneen, Bart De Strooper, Blanca Díaz-Castro, Cinthia Farina, Marc Freeman, Vittorio Gallo, James E Goldman, Steven A Goldman, Magdalena Götz, Antonia Gutiérrez, Philip G Haydon, Dieter H Heiland, Elly M Hol, Matthew G Holt, Masamitsu Iino, Ksenia V Kastanenka, Helmut Kettenmann, Baljit S Khakh, Schuichi Koizumi, C Justin Lee, Shane A Liddelow, Brian A MacVicar, Pierre Magistretti, Albee Messing, Anusha Mishra, Anna V Molofsky, Keith K Murai, Christopher M Norris, Seiji Okada, Stéphane H R Oliet, João F Oliveira, Aude Panatier, Vladimir Parpura, Marcela Pekna, Milos Pekny, Luc Pellerin, Gertrudis Perea, Beatriz G Pérez-Nievas, Frank W Pfrieger, Kira E Poskanzer, Francisco J Quintana, Richard M Ransohoff, Miriam Riquelme-Perez, Stefanie Robel, Christine R Rose, Jeffrey D Rothstein, Nathalie Rouach, David H Rowitch, Alexey Semyanov, Swetlana Sirko, Harald Sontheimer, Raymond A Swanson, Javier Vitorica, Ina-Beate Wanner, Levi B Wood, Jiaqian Wu, Binhai Zheng, Eduardo R Zimmer, Robert Zorec, Michael V Sofroniew, Alexei Verkhratsky
Reactive astrocyte nomenclature, definitions, and future directions.
J Neurol Neurosurg Psychiatry
Published

Fluid biomarkers in frontotemporal dementia: past, present and future.

Authors
Imogen Joanna Swift, Aitana Sogorb-Esteve, Carolin Heller, Matthis Synofzik, Markus Otto, Caroline Graff, Daniela Galimberti, Emily Todd, Amanda J Heslegrave, Emma Louise van der Ende, John Cornelis Van Swieten, Henrik Zetterberg, Jonathan Daniel Rohrer
Fluid biomarkers in frontotemporal dementia: past, present and future.
Sleep
Published

Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness.

Authors
Vincenzo Muto, Ekaterina Koshmanova, Pouya Ghaemmaghami, Mathieu Jaspar, Christelle Meyer, Mahmoud Elansary, Maxime Van Egroo, Daphne Chylinski, Christian Berthomier, Marie Brandewinder, Charlotte Mouraux, Christina Schmidt, Grégory Hammad, Wouter Coppieters, Naima Ahariz, Christian Degueldre, André Luxen, Eric Salmon, Christophe Phillips, Simon N Archer, Loic Yengo, Enda Byrne, Fabienne Collette, Michel Georges, Derk-Jan Dijk, Pierre Maquet, Peter M Visscher, Gilles Vandewalle
Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness.
Acta Neuropathol
Published

Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.

Authors
Arpan R Mehta, Jenna M Gregory, Owen Dando, Roderick N Carter, Karen Burr, Jyoti Nanda, David Story, Karina McDade, Colin Smith, Nicholas M Morton, Don J Mahad, Giles E Hardingham, Siddharthan Chandran, Bhuvaneish T Selvaraj
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.
Nat Commun
Published

Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.

Authors
Daniel Jutzi, Sébastien Campagne, Ralf Schmidt, Stefan Reber, Jonas Mechtersheimer, Foivos Gypas, Christoph Schweingruber, Martino Colombo, Christine von Schroetter, Fionna E Loughlin, Anny Devoy, Eva Hedlund, Mihaela Zavolan, Frédéric H-T Allain, Marc-David Ruepp
Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.