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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Alzheimers Dement
Published

Dementias Platform UK: Bringing genetics into life.

Authors
Ganna Leonenko, Sarah Bauermeister, Dipanwita Ghanti, Joshua Stevenson-Hoare, Emily Simmonds, Keeley Brookes, Kevin Morgan, Nishi Chaturvedi, Paul Elliott, Alan Thomas, Nicholas Wareham, John Gallacher, Valentina Escott-Price
Dementias Platform UK: Bringing genetics into life.
Nat Commun
Published

A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease.

Authors
Stergios Tsartsalis, Hannah Sleven, Nurun Fancy, Frank Wessely, Amy M Smith, Nanet Willumsen, To Ka Dorcas Cheung, Michal J Rokicki, Vicky Chau, Eseoghene Ifie, Combiz Khozoie, Olaf Ansorge, Xin Yang, Marion H Jenkyns, Karen Davey, Aisling McGarry, Robert C J Muirhead, Stephanie Debette, Johanna S Jackson, Axel Montagne, David R Owen, J Scott Miners, Seth Love, Caleb Webber, M Zameel Cader, Paul M Matthews
A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease.
Nature
Published

Genetic determinants of micronucleus formation in vivo.

Authors
D J Adams, B Barlas, R E McIntyre, I Salguero, L van der Weyden, A Barros, J R Vicente, N Karimpour, A Haider, M Ranzani, G Turner, N A Thompson, V Harle, R Olvera-León, C D Robles-Espinoza, A O Speak, N Geisler, W J Weninger, S H Geyer, J Hewinson, N A Karp, , B Fu, F Yang, Z Kozik, J Choudhary, L Yu, M S van Ruiten, B D Rowland, C J Lelliott, M Del Castillo Velasco-Herrera, R Verstraten, L Bruckner, A G Henssen, M A Rooimans, J de Lange, T J Mohun, M J Arends, K A Kentistou, P A Coelho, Y Zhao, H Zecchini, J R B Perry, S P Jackson, G Balmus
Genetic determinants of micronucleus formation in vivo.
N Engl J Med
Published

Cognition and Memory after Covid-19 in a Large Community Sample.

Authors
Adam Hampshire, Adriana Azor, Christina Atchison, William Trender, Peter J Hellyer, Valentina Giunchiglia, Masud Husain, Graham S Cooke, Emily Cooper, Adam Lound, Christl A Donnelly, Marc Chadeau-Hyam, Helen Ward, Paul Elliott
Cognition and Memory after Covid-19 in a Large Community Sample.
Clocks Sleep
Published

A Protocol for Evaluating Digital Technology for Monitoring Sleep and Circadian Rhythms in Older People and People Living with Dementia in the Community.

Authors
Ciro Della Monica, Kiran K G Ravindran, Giuseppe Atzori, Damion J Lambert, Thalia Rodriguez, Sara Mahvash-Mohammadi, Ullrich Bartsch, Anne C Skeldon, Kevin Wells, Adam Hampshire, Ramin Nilforooshan, Hana Hassanin, The Uk Dementia Research Institute Care Research Amp Technology Research Group, Victoria L Revell, Derk-Jan Dijk
A Protocol for Evaluating Digital Technology for Monitoring Sleep and Circadian Rhythms in Older People and People Living with Dementia in the Community.
Lancet Neurol
Published

Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis.

Authors
Marianne Chapleau, Renaud La Joie, Keir Yong, Federica Agosta, Isabel Elaine Allen, Liana Apostolova, John Best, Baayla D C Boon, Sebastian Crutch, Massimo Filippi, Giorgio Giulio Fumagalli, Daniela Galimberti, Jonathan Graff-Radford, Lea T Grinberg, David J Irwin, Keith A Josephs, Mario F Mendez, Patricio Chrem Mendez, Raffaella Migliaccio, Zachary A Miller, Maxime Montembeault, Melissa E Murray, Sára Nemes, Victoria Pelak, Daniela Perani, Jeffrey Phillips, Yolande Pijnenburg, Emily Rogalski, Jonathan M Schott, William Seeley, A Campbell Sullivan, Salvatore Spina, Jeremy Tanner, Jamie Walker, Jennifer L Whitwell, David A Wolk, Rik Ossenkoppele, Gil D Rabinovici,
Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis.
Eur Stroke J
Published

European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke.

Authors
Joanna M Wardlaw, Hugues Chabriat, Frank-Erik de Leeuw, Stéphanie Debette, Martin Dichgans, Fergus Doubal, Hanna Jokinen, Aristeidis H Katsanos, Raffaele Ornello, Leonardo Pantoni, Marco Pasi, Aleksandra M Pavlovic, Salvatore Rudilosso, Reinhold Schmidt, Julie Staals, Martin Taylor-Rowan, Salman Hussain, Arne G Lindgren
European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke.
NPJ Digit Med
Published

Digital remote monitoring for screening and early detection of urinary tract infections.

Authors
Alexander Capstick, Francesca Palermo, Kimberley Zakka, Nan Fletcher-Lloyd, Chloe Walsh, Tianyu Cui, Samaneh Kouchaki, Raphaella Jackson, Martin Tran, Michael Crone, Kirsten Jensen, Paul Freemont, Ravi Vaidyanathan, Magdalena Kolanko, Jessica True, Sarah Daniels, David Wingfield, , Ramin Nilforooshan, Payam Barnaghi
Digital remote monitoring for screening and early detection of urinary tract infections.
Acta Neuropathol
Published

p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.

Authors
Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durrant
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.