Publications

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Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

EMBO J

Published Oct 04, 2023

Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.

Authors

Javier Rueda-Carrasco, Dimitra Sokolova, Sang-Eun Lee, Thomas Childs, Natália Jurčáková, Gerard Crowley, Sebastiaan De Schepper, Judy Z Ge, Joanne I Lachica, Christina E Toomey, Oliver J Freeman, John Hardy, Samuel J Barnes, Tammaryn Lashley, Beth Stevens, Sunghoe Chang, Soyon Hong

Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.

Lancet Neurol

Published Sep 21, 2023

Preparing for disease-modifying therapies in Alzheimer's disease.

Authors

Christopher R S Belder, Jonathan M Schott, Nick C Fox

Preparing for disease-modifying therapies in Alzheimer's disease.

Cell Reports Medicine

Published Sep 19, 2023

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8

Authors

Makis Tzioras, Michael J.D. Daniels, Caitlin Davies, Paul Baxter, Declan King, Sean McKay, Balazs Varga, Karla Popovic, Madison Hernandez, Anna J. Stevenson, Jack Barrington, Elizabeth Drinkwater, Julia Borella, Rebecca K. Holloway, Jane Tulloch, Jonathan Moss, Clare Latta, Jothy Kandasamy, Drahoslav Sokol, Colin Smith, Veronique E. Miron, Ragnhildur Thóra Káradóttir, Giles E. Hardingham, Christopher M. Henstridge, Paul M. Brennan, Barry W. McColl, Tara L. Spires-Jones

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8

Cell Rep Med

Published Sep 19, 2023

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8.

Authors

Makis Tzioras, Michael J D Daniels, Caitlin Davies, Paul Baxter, Declan King, Sean McKay, Balazs Varga, Karla Popovic, Madison Hernandez, Anna J Stevenson, Jack Barrington, Elizabeth Drinkwater, Julia Borella, Rebecca K Holloway, Jane Tulloch, Jonathan Moss, Clare Latta, Jothy Kandasamy, Drahoslav Sokol, Colin Smith, Veronique E Miron, Ragnhildur Thóra Káradóttir, Giles E Hardingham, Christopher M Henstridge, Paul M Brennan, Barry W McColl, Tara L Spires-Jones

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8.

Ann Hum Genet

Published Sep 17, 2023

Pitfalls of predicting age-related traits by polygenic risk scores.

Authors

Valentina Escott-Price, Karl Michael Schmidt

Pitfalls of predicting age-related traits by polygenic risk scores.

PLoS One

Published Sep 11, 2023

A systematic review and meta-analysis of thigmotactic behaviour in the open field test in rodent models associated with persistent pain.

Authors

Xue Ying Zhang, Marta Diaz-delCastillo, Lingsi Kong, Natasha Daniels, William MacIntosh-Smith, Aya Abdallah, Dominik Domanski, Denis Sofrenovic, Tsz Pui Skel Yeung, Diego Valiente, Jan Vollert, Emily Sena, Andrew S Rice, Nadia Soliman

A systematic review and meta-analysis of thigmotactic behaviour in the open field test in rodent models associated with persistent pain.

Sci Data

Published Sep 09, 2023

TIHM: An open dataset for remote healthcare monitoring in dementia.

Authors

Francesca Palermo, Yu Chen, Alexander Capstick, Nan Fletcher-Loyd, Chloe Walsh, Samaneh Kouchaki, Jessica True, Olga Balazikova, Eyal Soreq, Gregory Scott, Helen Rostill, Ramin Nilforooshan, Payam Barnaghi

TIHM: An open dataset for remote healthcare monitoring in dementia.

Sci Data

Published Sep 09, 2023

TIHM: An open dataset for remote healthcare monitoring in dementia.

Authors

TIHM: An open dataset for remote healthcare monitoring in dementia.

Nat Commun

Published Sep 04, 2023

Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39.

Authors

Sébastien Campagne, Daniel Jutzi, Florian Malard, Maja Matoga, Ksenija Romane, Miki Feldmuller, Martino Colombo, Marc-David Ruepp, Frédéric H-T Allain

Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39.

Nat Commun

Published Sep 04, 2023

Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39.

Authors

Sébastien Campagne, Daniel Jutzi, Florian Malard, Maja Matoga, Ksenija Romane, Miki Feldmuller, Martino Colombo, Marc-David Ruepp, Frédéric H-T Allain

Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39.

Neurobiol Dis

Published Sep 04, 2023

The consequences of neurodegenerative disease on neuron-astrocyte metabolic and redox interactions.

Authors

Zoeb Jiwaji, Giles E Hardingham

The consequences of neurodegenerative disease on neuron-astrocyte metabolic and redox interactions.

JCO Precis Oncol

Published Sep 02, 2023

Pan-Cancer Analysis of Copy-Number Features Identifies Recurrent Signatures and a Homologous Recombination Deficiency Biomarker to Predict Poly (ADP-Ribose) Polymerase Inhibitor Response.

Authors

Jay A Moore, Kuei-Ting Chen, Russell Madison, Justin Y Newberg, Zoe Fleischmann, Shuoguo Wang, Radwa Sharaf, Karthikeyan Murugesan, Bernard J Fendler, Jason Hughes, Alexa B Schrock, Priti S Hegde, Geoffrey R Oxnard, David Fabrizio, Garrett M Frampton, Emmanuel S Antonarakis, Ethan S Sokol, Dexter X Jin

Pan-Cancer Analysis of Copy-Number Features Identifies Recurrent Signatures and a Homologous Recombination Deficiency Biomarker to Predict Poly (ADP-Ribose) Polymerase Inhibitor Response.

Nat Commun

Published Aug 28, 2023

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.

Authors

Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C Marzin, Robert C J Muirhead, Irene Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C Trolese, Takashi Saito, Takaomi C Saido, Katharine H Wiltshire, Paula Beltran-Lobo, Alexandra Phillips, Jack Antel, Luke Healy, Marie-France Dorion, Dylan A Galloway, Rochelle Y Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M Badina, Enikö Kövari, Caterina Bendotti, Eleonora Aronica, Carola I Radulescu, Jia Hui Wong, Anna M Barron, Amy M Smith, Samuel J Barnes, David W Hampton, Paul van der Valk, Steven Jacobson, Owain W Howell, David Baker, Markus Kipp, Hannes Kaddatz, Benjamin B Tournier, Philippe Millet, Paul M Matthews, Craig S Moore, Sandra Amor, David R Owen

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.

Nat Commun

Published Aug 28, 2023

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.

Authors

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.

Brain Commun

Published Aug 25, 2023

Pathway-specific polygenic scores for Alzheimer's disease are associated with changes in brain structure in younger and older adults.

Authors

Judith R Harrison, Sonya F Foley, Emily Baker, Matthew Bracher-Smith, Peter Holmans, Evie Stergiakouli, David E J Linden, Xavier Caseras, Derek K Jones, Valentina Escott-Price

Pathway-specific polygenic scores for Alzheimer's disease are associated with changes in brain structure in younger and older adults.

Int J Mol Sci

Published Aug 23, 2023

A Scoping Review on Biomarkers of Endothelial Dysfunction in Small Vessel Disease: Molecular Insights from Human Studies.

Authors

Daniela Jaime Garcia, Audrey Chagnot, Joanna M Wardlaw, Axel Montagne

A Scoping Review on Biomarkers of Endothelial Dysfunction in Small Vessel Disease: Molecular Insights from Human Studies.

Int J Mol Sci

Published Aug 23, 2023

A Scoping Review on Biomarkers of Endothelial Dysfunction in Small Vessel Disease: Molecular Insights from Human Studies.

Authors

Daniela Jaime Garcia, Audrey Chagnot, Joanna M Wardlaw, Axel Montagne

A Scoping Review on Biomarkers of Endothelial Dysfunction in Small Vessel Disease: Molecular Insights from Human Studies.

Brain and Neuroscience Advances

Published Aug 17, 2023

Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model

Authors

Caitlin Davies, Jane Tulloch, Ellie Yip, Lydie Currie, Martí Colom-Cadena, Susanne Wegmann, Barry T Hyman, Lewis Wilkins, Monique Hooley, Makis Tzioras, Tara L. Spires-Jones

Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model