Publications

Featured

Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Eur J Neurosci

Published Jan 28, 2021

Maintained memory and long-term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau.

Authors

Jane Tulloch, Olga Netsyk, Eleanor K Pickett, Abigail G Herrmann, Pooja Jain, Anna J Stevenson, Iris Oren, Oliver Hardt, Tara L Spires-Jones

Maintained memory and long-term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau.

Nat Protoc

Published Jan 25, 2021

Nuclei isolation of multiple brain cell types for omics interrogation.

Authors

Alexi Nott, Johannes C M Schlachetzki, Bethany R Fixsen, Christopher K Glass

Nuclei isolation of multiple brain cell types for omics interrogation.

Sleep

Published Jan 21, 2021

Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness.

Authors

Vincenzo Muto, Ekaterina Koshmanova, Pouya Ghaemmaghami, Mathieu Jaspar, Christelle Meyer, Mahmoud Elansary, Maxime Van Egroo, Daphne Chylinski, Christian Berthomier, Marie Brandewinder, Charlotte Mouraux, Christina Schmidt, Grégory Hammad, Wouter Coppieters, Naima Ahariz, Christian Degueldre, André Luxen, Eric Salmon, Christophe Phillips, Simon N Archer, Loic Yengo, Enda Byrne, Fabienne Collette, Michel Georges, Derk-Jan Dijk, Pierre Maquet, Peter M Visscher, Gilles Vandewalle

Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness.

Sleep

Published Jan 21, 2021

Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness.

Authors

Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness.

Nat Commun

Published Jan 13, 2021

Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence.

Authors

Sebastian R Schreglmann, David Wang, Robert L Peach, Junheng Li, Xu Zhang, Anna Latorre, Edward Rhodes, Emanuele Panella, Antonino M Cassara, Edward S Boyden, Mauricio Barahona, Sabato Santaniello, John Rothwell, Kailash P Bhatia, Nir Grossman

Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence.

Nat Commun

Published Jan 13, 2021

Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence.

Authors

Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence.

Front Cell Neurosci

Published Jan 07, 2021

An "Outside-In" and "Inside-Out" Consideration of Complement in the Multiple Sclerosis Brain: Lessons From Development and Neurodegenerative Diseases.

Authors

B Paul Morgan, Jennifer L Gommerman, Valeria Ramaglia

An "Outside-In" and "Inside-Out" Consideration of Complement in the Multiple Sclerosis Brain: Lessons From Development and Neurodegenerative Diseases.

Acta Neuropathol

Published Jan 04, 2021

Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.

Authors

Arpan R Mehta, Jenna M Gregory, Owen Dando, Roderick N Carter, Karen Burr, Jyoti Nanda, David Story, Karina McDade, Colin Smith, Nicholas M Morton, Don J Mahad, Giles E Hardingham, Siddharthan Chandran, Bhuvaneish T Selvaraj

Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.

Fac Rev

Published Jan 01, 2021

Insight into the role of phosphatidylserine in complement-mediated synapse loss in Alzheimer's disease.

Authors

Dimitra Sokolova, Thomas Childs, Soyon Hong

Insight into the role of phosphatidylserine in complement-mediated synapse loss in Alzheimer's disease.

Front Neurosci

Published Jan 01, 2021

Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking.

Authors

Cristina Román-Vendrell, Audrey T Medeiros, John B Sanderson, Haiyang Jiang, Tim Bartels, Jennifer R Morgan

Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking.

Brain Commun

Published Jan 01, 2021

TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain.

Authors

Jasmine Harley, Cathleen Hagemann, Andrea Serio, Rickie Patani

TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain.

Brain Commun

Published Jan 01, 2021

Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective.

Authors

Charis Wong, Maria Stavrou, Elizabeth Elliott, Jenna M Gregory, Nigel Leigh, Ashwin A Pinto, Timothy L Williams, Jeremy Chataway, Robert Swingler, Mahesh K B Parmar, Nigel Stallard, Christopher J Weir, Richard A Parker, Amina Chaouch, Hisham Hamdalla, John Ealing, George Gorrie, Ian Morrison, Callum Duncan, Peter Connelly, Francisco Javier Carod-Artal, Richard Davenport, Pablo Garcia Reitboeck, Aleksandar Radunovic, Venkataramanan Srinivasan, Jenny Preston, Arpan R Mehta, Danielle Leighton, Stella Glasmacher, Emily Beswick, Jill Williamson, Amy Stenson, Christine Weaver, Judith Newton, Dawn Lyle, Rachel Dakin, Malcolm Macleod, Suvankar Pal, Siddharthan Chandran

Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective.

Wellcome Open Res

Published Jan 01, 2021

Rapid design and implementation of an adaptive pooling workflow for SARS-CoV-2 testing in an NHS diagnostic laboratory: a proof-of-concept study.

Authors

Michael Crone, Paul Randell, Zoey Herm, Arthi Anand, Saghar Missaghian-Cully, Loren Perelman, Panagiotis Pantelidis, Paul Freemont

Rapid design and implementation of an adaptive pooling workflow for SARS-CoV-2 testing in an NHS diagnostic laboratory: a proof-of-concept study.

Front Robot AI

Published Jan 01, 2021

Robotic Telemedicine for Mental Health: A Multimodal Approach to Improve Human-Robot Engagement.

Authors

Maria R Lima, Maitreyee Wairagkar, Nirupama Natarajan, Sridhar Vaitheswaran, Ravi Vaidyanathan

Robotic Telemedicine for Mental Health: A Multimodal Approach to Improve Human-Robot Engagement.

Acta Neuropathol

Published Dec 21, 2020

Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease.

Authors

Nils Korte, Ross Nortley, David Attwell

Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease.

Nat Commun

Published Dec 11, 2020

Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.

Authors

Daniel Jutzi, Sébastien Campagne, Ralf Schmidt, Stefan Reber, Jonas Mechtersheimer, Foivos Gypas, Christoph Schweingruber, Martino Colombo, Christine von Schroetter, Fionna E Loughlin, Anny Devoy, Eva Hedlund, Mihaela Zavolan, Frédéric H-T Allain, Marc-David Ruepp

Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.

Nat Commun

Published Dec 11, 2020

Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.

Authors

Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.

Front Immunol

Published Dec 10, 2020

Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species.

Authors

Wioleta M Zelek, B Paul Morgan

Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species.