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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Brain communications
Published

Investigation of the genetic aetiology of Lewy body diseases with and without dementia

Authors
Lesley Yue Wu, Raquel Real, Alejandro Martinez-Carrasco, Ruth Chia, Michael A Lawton, Maryam Shoai, Catherine Bresner, Cornelis Blauwendraat, Andrew B Singleton, Mina Ryten, International Lewy Body Dementia Genomics Consortium, Sonja W Scholz, Bryan J Traynor, Nigel M Williams, Michele T M Hu, Yoav Ben-Shlomo, Donald G Grosset, John Hardy, Huw R Morris
Investigation of the genetic aetiology of Lewy body diseases with and without dementia
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published

Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2

Authors
Jong-Chan Park, Jong Won Han, Woochan Lee, Jieun Kim, Sang-Eun Lee, Dongjoon Lee, Hayoung Choi, Jihui Han, You Jung Kang, Yen N Diep, Hansang Cho, Rian Kang, Won Jong Yu, Jean Lee, Murim Choi, Sun-Wha Im, Jong-Il Kim, Inhee Mook-Jung
Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2
bioRxiv : the preprint server for biology
Published

Loss of TDP-43 induces synaptic dysfunction that is rescued by <em>UNC13A</em> splice-switching ASOs

Authors
Matthew J Keuss, Peter Harley, Eugeni Ryadnov, Rachel E Jackson, Matteo Zanovello, Oscar G Wilkins, Simone Barattucci, Puja R Mehta, Marcio G Oliveira, Joanna E Parkes, Aparna Sinha, Andrés F Correa-Sánchez, Peter L Oliver, Elizabeth M C Fisher, Giampietro Schiavo, Mala Shah, Juan Burrone, Pietro Fratta
Loss of TDP-43 induces synaptic dysfunction that is rescued by <em>UNC13A</em> splice-switching ASOs
Journal of experimental & clinical cancer research : CR
Published

Unlocking the diagnostic power of plasma extracellular vesicle miR-200 family in pancreatic ductal adenocarcinoma

Authors
Daniel S K Liu, Jisce R Puik, Bhavik Y Patel, Morten T Venø, Mahrou Vahabi, Mireia Mato Prado, Jason P Webber, Eleanor Rees, Flora M Upton, Kate Bennett, Catherine Blaker, Benoit Immordino, Annalisa Comandatore, Luca Morelli, Shivan Sivakumar, Rutger-Jan Swijnenburg, Marc G Besselink, Long R Jiao, Geert Kazemier, Elisa Giovannetti, Jonathan Krell, Adam E Frampton
Unlocking the diagnostic power of plasma extracellular vesicle miR-200 family in pancreatic ductal adenocarcinoma
Brain, behavior, and immunity
Published

Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression

Authors
Michael R Duggan, Gabriela T Gomez, Cassandra M Joynes, Murat Bilgel, Jingsha Chen, Nicola Fattorelli, Timothy J Hohman, Renzo Mancuso, Jenifer Cordon, Tonnar Castellano, Mary Ellen I Koran, Julián Candia, Alexandria Lewis, Abhay Moghekar, Nicholas J Ashton, Przemysław R Kac, Thomas K Karikari, Kaj Blennow, Henrik Zetterberg, Anna Martinez-Muriana, Bart De Strooper, Madhav Thambisetty, Luigi Ferrucci, Rebecca F Gottesman, Josef Coresh, Susan M Resnick, Keenan A Walker
Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression
The Journal of physiology
Published

Bridging the gap between experimental control and ecological validity in human sensorimotor science

Authors
Jonathan Tsay, Nathan Steadman, Melanie Fleming, Mareike Gann, Irene Di Giulio, Cosima Graef, Jinpei Han, Kavindu Jayasinghe, Matthew Mitchell, Robert Chen, Kausar Raheel, Edgar Semedo, Raul Sîmpetru, Kurnia Putri Utami, Allie Williams, Ziyue Zhu, Charlotte Stagg, Shlomi Haar
Bridging the gap between experimental control and ecological validity in human sensorimotor science
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease

Authors
Aurore Delvenne, Johan Gobom, Suzanne E Schindler, Mara Ten Kate, Lianne M Reus, Valerija Dobricic, Betty M Tijms, Tammie L S Benzinger, Carlos Cruchaga, Charlotte E Teunissen, Inez Ramakers, Pablo Martinez-Lage, Mikel Tainta, Rik Vandenberghe, Jolien Schaeverbeke, Sebastiaan Engelborghs, Ellen De Roeck, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Frederik Barkhof, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Stephanie J B Vos
CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Longitudinal plasma phosphorylated-tau217 and other related biomarkers in a non-demented Alzheimer's risk-enhanced sample

Authors
Lianlian Du, Rebecca E Langhough, Rachael E Wilson, Ramiro Eduardo Rea Reyes, Bruce P Hermann, Erin M Jonaitis, Tobey J Betthauser, Nathaniel A Chin, Bradley Christian, Lauren Chaby, Andreas Jeromin, Guglielmo Di Molfetta, Wagner S Brum, Burak Arslan, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, Sterling C Johnson
Longitudinal plasma phosphorylated-tau217 and other related biomarkers in a non-demented Alzheimer's risk-enhanced sample
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases

Authors
Daniela Andriuta, Julie Ottoy, Myuri Ruthirakuhan, Ginelle Feliciano, Allison A Dilliott, Robert A Hegele, Fuqiang Gao, Paula M McLaughlin, Jennifer S Rabin, Madeline Wood Alexander, Christopher J M Scott, Vanessa Yhap, Courtney Berezuk, Miracle Ozzoude, Walter Swardfager, Julia Zebarth, M Carmela Tartaglia, Ekaterina Rogaeva, David F Tang-Wai, Leanne Casaubon, Sanjeev Kumar, Dar Dowlatshahi, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, Corinne E Fischer, Michael Borrie, Ayman Hassan, Malcolm A Binns, Morris Freedman, Howard Chertkow, Elizabeth Finger, Andrew Frank, Robert Bartha, Sean Symons, Henrik Zetterberg, Richard H Swartz, Mario Masellis, Sandra E Black, Joel Ramirez, ONDRI Investigators
Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases
Nature
Published

Author Correction: Microglia regulate central nervous system myelin growth and integrity

Authors
Niamh B McNamara, David A D Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F J Bogie, Alana Hoffmann, Rebecca K Holloway, Irene Molina-Gonzalez, Katharine E Askew, Stephen Mitchell, William Mungall, Michael Dodds, Carsten Dittmayer, Jonathan Moss, Jamie Rose, Stefan Szymkowiak, Lukas Amann, Barry W McColl, Marco Prinz, Tara L Spires-Jones, Werner Stenzel, Karen Horsburgh, Jerome J A Hendriks, Clare Pridans, Rieko Muramatsu, Anna Williams, Josef Priller, Veronique E Miron
Author Correction: Microglia regulate central nervous system myelin growth and integrity
Science translational medicine
Published

A nose for tau

Authors
Soraya Meftah, Claire S Durrant, Tara L Spires-Jones
A nose for tau
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Time-encoded ASL reveals lower cerebral blood flow in the early AD continuum

Authors
Carles Falcon, Paula Montesinos, Lena Václavů, Michalis Kassinopoulos, Carolina Minguillon, Karine Fauria, Diego Cascales-Lahoz, José Contador, Aida Fernández-Lebrero, Irene Navalpotro, Albert Puig-Pijoan, Oriol Grau-Rivera, Gwendlyn Kollmorgen, Clara Quijano-Rubio, José Luis Molinuevo, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, Matthias J P Van Osch, Javier Sanchez-Gonzalez, Juan Domingo Gispert
Time-encoded ASL reveals lower cerebral blood flow in the early AD continuum
Nat Neurosci
Published

Central nervous system-associated macrophages modulate the immune response following stroke in aged mice.

Authors
Damien Levard, Célia Seillier, Mathys Bellemain-Sagnard, Antoine Philippe Fournier, Eloïse Lemarchand, Chantal Dembech, Gaëtan Riou, Karina McDade, Colin Smith, Conor McQuaid, Axel Montagne, Lukas Amann, Marco Prinz, Denis Vivien, Marina Rubio
Central nervous system-associated macrophages modulate the immune response following stroke in aged mice.
Nature communications
Published

Author Correction: The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration

Authors
Sarah Opie-Martin, Alfredo Iacoangeli, Simon D Topp, Olubunmi Abel, Keith Mayl, Puja R Mehta, Aleksey Shatunov, Isabella Fogh, Harry Bowles, Naomi Limbachiya, Thomas P Spargo, Ahmad Al-Khleifat, Kelly L Williams, Jennifer Jockel-Balsarotti, Taha Bali, Wade Self, Lyndal Henden, Garth A Nicholson, Nicola Ticozzi, Diane McKenna-Yasek, Lu Tang, Pamela J Shaw, Adriano Chio, Albert Ludolph, Jochen H Weishaupt, John E Landers, Jonathan D Glass, Jesus S Mora, Wim Robberecht, Philip Van Damme, Russell McLaughlin, Orla Hardiman, Leonard van den Berg, Jan H Veldink, Phillippe Corcia, Zorica Stevic, Nailah Siddique, Vincenzo Silani, Ian P Blair, Dong-Sheng Fan, Florence Esselin, Elisa de la Cruz, William Camu, Nazli A Basak, Teepu Siddique, Timothy Miller, Robert H Brown, Ammar Al-Chalabi, Christopher E Shaw
Author Correction: The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration
Cell reports
Published

Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport

Authors
Tasuku Konno, Pierre Parutto, Cécile C Crapart, Valentina Davì, David M D Bailey, Mosab Ali Awadelkareem, Colin Hockings, Aidan I Brown, Katherine M Xiang, Anamika Agrawal, Joseph E Chambers, Molly J Vander Werp, Katherine M Koning, Louis Mounir Elfari, Sam Steen, Emmanouil Metzakopian, Laura M Westrate, Elena F Koslover, Edward Avezov
Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport