Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
Cell reports
Published

Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity

Authors
Anirudh Patir, Jack Barrington, Stefan Szymkowiak, Gaia Brezzo, Dana Straus, Alessio Alfieri, Lucas Lefevre, Zhaoyuan Liu, Florent Ginhoux, Neil C Henderson, Karen Horsburgh, Prakash Ramachandran, Barry W McColl
Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity
Neuro-degenerative diseases
Published

The Taxonomy of Subjective Cognitive Decline: Proposal and First Clinical Evidence from the Geneva Memory Clinic Cohort

Authors
Federica Ribaldi, Rafael Palomo, Daniele Altomare, Max Scheffler, Frederic Assal, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Marc Abramowicz, Valentina Garibotto, Christian Chicherio, Giovanni B Frisoni
The Taxonomy of Subjective Cognitive Decline: Proposal and First Clinical Evidence from the Geneva Memory Clinic Cohort
Alzheimer's research & therapy
Published

Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired elderly

Authors
Mikko Koivumäki, Laura Ekblad, Juan Lantero-Rodriguez, Nicholas J Ashton, Thomas K Karikari, Semi Helin, Riitta Parkkola, Jyrki Lötjönen, Henrik Zetterberg, Kaj Blennow, Juha O Rinne, Anniina Snellman
Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired elderly
Computers in biology and medicine
Published

Paired plasma lipidomics and proteomics analysis in the conversion from mild cognitive impairment to Alzheimer's disease

Authors
Alicia Gómez-Pascual, Talel Naccache, Jin Xu, Kourosh Hooshmand, Asger Wretlind, Martina Gabrielli, Marta Tiffany Lombardo, Liu Shi, Noel J Buckley, Betty M Tijms, Stephanie J B Vos, Mara Ten Kate, Sebastiaan Engelborghs, Kristel Sleegers, Giovanni B Frisoni, Anders Wallin, Alberto Lleó, Julius Popp, Pablo Martinez-Lage, Johannes Streffer, Frederik Barkhof, Henrik Zetterberg, Pieter Jelle Visser, Simon Lovestone, Lars Bertram, Alejo J Nevado-Holgado, Alice Gualerzi, Silvia Picciolini, Petroula Proitsi, Claudia Verderio, Juan A Botía, Cristina Legido-Quigley
Paired plasma lipidomics and proteomics analysis in the conversion from mild cognitive impairment to Alzheimer's disease
Molecular neurodegeneration
Published

Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology

Authors
Rebecca L Winfree, Emma Nolan, Logan Dumitrescu, Kaj Blennow, Henrik Zetterberg, Katherine A Gifford, Kimberly R Pechman, Mabel Seto, Vladislav A Petyuk, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohman, Alzheimer’s Disease Neuroimaging Initiative*
Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology
Immunity & ageing : I & A
Published

The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people

Authors
Tovia Jacobs, Sean R Jacobson, Juan Fortea, Jeffrey S Berger, Alok Vedvyas, Karyn Marsh, Tianshe He, Eugenio Gutierrez-Jimenez, Nathanael R Fillmore, Moses Gonzalez, Luisa Figueredo, Naomi L Gaggi, Chelsea Reichert Plaska, Nunzio Pomara, Esther Blessing, Rebecca Betensky, Henry Rusinek, Henrik Zetterberg, Kaj Blennow, Lidia Glodzik, Thomas M Wisniweski, Mony J de Leon, Ricardo S Osorio, Jaime Ramos-Cejudo, Alzheimer’s Disease Neuroimaging Initiative
The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people
NPJ Parkinson's disease
Published

Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid of de novo Parkinson's disease

Authors
Michael Bartl, Johanna Nilsson, Mohammed Dakna, Sandrina Weber, Sebastian Schade, Mary Xylaki, Bárbara Fernandes Gomes, Marielle Ernst, Maria-Lucia Muntean, Friederike Sixel-Döring, Claudia Trenkwalder, Henrik Zetterberg, Ann Brinkmalm, Brit Mollenhauer
Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid of de novo Parkinson's disease
The Lancet. Neurology
Published

Climate change and disorders of the nervous system

Authors
Sanjay M Sisodiya, Medine I Gulcebi, Francesco Fortunato, James D Mills, Ethan Haynes, Elvira Bramon, Paul Chadwick, Olga Ciccarelli, Anthony S David, Kris De Meyer, Nick C Fox, Joanna Davan Wetton, Martin Koltzenburg, Dimitri M Kullmann, Manju A Kurian, Hadi Manji, Mark A Maslin, Manjit Matharu, Hugh Montgomery, Marina Romanello, David J Werring, Lisa Zhang, Karl J Friston, Michael G Hanna
Climate change and disorders of the nervous system
Annals of clinical and translational neurology
Published

Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure

Authors
Mario Tranfa, Luigi Lorenzini, Lyduine E Collij, David Vállez García, Silvia Ingala, Giuseppe Pontillo, Leonard Pieperhoff, Alessio Maranzano, Robin Wolz, Sven Haller, Kaj Blennow, Giovanni Frisoni, Carole H Sudre, Gael Chételat, Michael Ewers, Pierre Payoux, Adam Waldman, Pablo Martinez-Lage, Adam J Schwarz, Craig W Ritchie, Joanna M Wardlaw, Juan Domingo Gispert, Arturo Brunetti, Henk J M M Mutsaerts, Alle Meije Wink, Frederik Barkhof
Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure
BMJ neurology open
Published

Recreational nitrous oxide and thrombotic events: a case series

Authors
Marta Patyjewicz, Devan Mair, Safiya A Zaloum, Barbara Onen, Joseph Walton, Ruth Dobson, Christine Joerres, Apeksha Madhusudan Shah, Peter MacCallum, Thomas H Massey, Tadbir Bariana, Veronica White, Sarah A De Freitas, Alastair Noyce
Recreational nitrous oxide and thrombotic events: a case series
Molecular neurodegeneration
Published

Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting

Authors
Xuemei Zeng, Yijun Chen, Anuradha Sehrawat, Jihui Lee, Tara K Lafferty, Julia Kofler, Sarah B Berman, Robert A Sweet, Dana L Tudorascu, William E Klunk, Milos D Ikonomovic, Anna Pfister, Henrik Zetterberg, Beth E Snitz, Anne D Cohen, Victor L Villemagne, Tharick A Pascoal, M Llyas Kamboh, Oscar I Lopez, Kaj Blennow, Thomas K Karikari
Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting
Nature neuroscience
Published

Brain clearance is reduced during sleep and anesthesia

Authors
Andawei Miao, Tianyuan Luo, Bryan Hsieh, Christopher J Edge, Morgan Gridley, Ryan Tak Chun Wong, Timothy G Constandinou, William Wisden, Nicholas P Franks
Brain clearance is reduced during sleep and anesthesia